(Q28506163)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9768755%20AND%20SRC:MED&resulttype=core&format=json

5 December 2019

title

Targeted disruption of the catalytic subunit of the DNA-PK gene in mice confers severe combined immunodeficiency and radiosensitivity (English)

2 references

24 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9768755%20AND%20SRC:MED&resulttype=core&format=json

Protein kinase, DNA activated, catalytic polypeptide

5 December 2019

main subject

1 reference

severe combined immunodeficiency

GOA release 2020-03-11

1 reference

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9768755%20AND%20SRC:MED&resulttype=core&format=json

5 December 2019

Stephen P Jackson

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9768755%20AND%20SRC:MED&resulttype=core&format=json

5 December 2019

author name string

G E Taccioli

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9768755%20AND%20SRC:MED&resulttype=core&format=json

5 December 2019

A G Amatucci

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9768755%20AND%20SRC:MED&resulttype=core&format=json

5 December 2019

H J Beamish

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9768755%20AND%20SRC:MED&resulttype=core&format=json

5 December 2019

X H Xiang

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9768755%20AND%20SRC:MED&resulttype=core&format=json

5 December 2019

M I Torres Arzayus

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9768755%20AND%20SRC:MED&resulttype=core&format=json

5 December 2019

A Priestley

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9768755%20AND%20SRC:MED&resulttype=core&format=json

5 December 2019

A Marshak Rothstein

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9768755%20AND%20SRC:MED&resulttype=core&format=json

5 December 2019

P A Jeggo

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9768755%20AND%20SRC:MED&resulttype=core&format=json

5 December 2019

V L Herrera

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9768755%20AND%20SRC:MED&resulttype=core&format=json

5 December 2019

language of work or name

English

0 references

publication date

1 September 1998

2 references

24 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9768755%20AND%20SRC:MED&resulttype=core&format=json

5 December 2019

2 references

24 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9768755%20AND%20SRC:MED&resulttype=core&format=json

5 December 2019

volume

9

2 references

24 January 2017

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5 December 2019

issue

3

2 references

24 January 2017

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5 December 2019

page(s)

355-366

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9768755%20AND%20SRC:MED&resulttype=core&format=json

The DNA-activated protein kinase -- DNA-PK

5 December 2019

cites work

1 reference

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7 January 2021

Nonsense mutation at Tyr-4046 in the DNA-dependent protein kinase catalytic subunit of severe combined immune deficiency mice

1 reference

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7 January 2021

scid mutation in mice confers hypersensitivity to ionizing radiation and a deficiency in DNA double-strand break repair

1 reference

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7 January 2021

Defective DNA-dependent protein kinase activity is linked to V(D)J recombination and DNA repair defects associated with the murine scid mutation.

1 reference

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7 January 2021

Identification of a nonsense mutation in the carboxyl-terminal region of DNA-dependent protein kinase catalytic subunit in the scid mouse

1 reference

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7 January 2021

p53 is required for both radiation-induced differentiation and rescue of V(D)J rearrangement in scid mouse thymocytes

1 reference

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7 January 2021

The SCID mouse mutant: definition, characterization, and potential uses

1 reference

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7 January 2021

Complementation of the ionizing radiation sensitivity, DNA end binding, and V(D)J recombination defects of double-strand break repair mutants by the p86 Ku autoantigen

1 reference

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7 January 2021

T-lymphocyte development in scid mice is arrested shortly after the initiation of T-cell receptor delta gene recombination

1 reference

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7 January 2021

Biased T-cell receptor delta element recombination in scid thymocytes

1 reference

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7 January 2021

A DNA-activated protein kinase from HeLa cell nuclei

1 reference

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7 January 2021

Rescue of T cell-specific V(D)J recombination in SCID mice by DNA-damaging agents

1 reference

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7 January 2021

Biochemical and genetic defects in the DNA-dependent protein kinase in murine scid lymphocytes

1 reference

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7 January 2021

Ku86 defines the genetic defect and restores X-ray resistance and V(D)J recombination to complementation group 5 hamster cell mutants

1 reference

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7 January 2021

DNA-dependent protein kinase activity is absent in xrs-6 cells: implications for site-specific recombination and DNA double-strand break repair

1 reference

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7 January 2021

The scid mutation in mice causes a general defect in DNA repair

1 reference

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7 January 2021

A targeted DNA-PKcs-null mutation reveals DNA-PK-independent functions for KU in V(D)J recombination

1 reference

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7 January 2021

Growth retardation and leaky SCID phenotype of Ku70-deficient mice.

1 reference

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7 January 2021

Development of CD4+CD8+ thymocytes in RAG-deficient mice through a T cell receptor beta chain-independent pathway

1 reference

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7 January 2021

DNA-dependent protein kinase: DNA binding and activation in the absence of Ku

1 reference

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7 January 2021

DNA-dependent protein kinase catalytic subunit: a relative of phosphatidylinositol 3-kinase and the ataxia telangiectasia gene product

1 reference

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7 January 2021

A link between double-strand break-related repair and V(D)J recombination: the scid mutation

1 reference

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7 January 2021

DNA-PK: at the cross-roads of biochemistry and genetics

1 reference

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7 January 2021

Menage à trois: double strand break repair, V(D)J recombination and DNA-PK.

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980618-4

7 January 2021

DNA-PKcs: a T-cell tumour suppressor encoded at the mouse scid locus

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980618-4

7 January 2021

p53 prevents maturation to the CD4+CD8+ stage of thymocyte differentiation in the absence of T cell receptor rearrangement.

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980618-4

7 January 2021

DNA-dependent kinase (p350) as a candidate gene for the murine SCID defect

1 reference

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7 January 2021

The DNA-dependent protein kinase, DNA-PK: 10 years and no ends in sight

1 reference

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7 January 2021

The mechanism of V(D)J joining: lessons from molecular, immunological, and comparative analyses

1 reference

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7 January 2021

The XRCC4 gene encodes a novel protein involved in DNA double-strand break repair and V(D)J recombination

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980618-4

7 January 2021

The defect in murine severe combined immune deficiency: joining of signal sequences but not coding segments in V(D)J recombination.

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980618-4

7 January 2021

Transient restoration of gene rearrangement at multiple T cell receptor loci in gamma-irradiated scid mice

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980618-4

7 January 2021

The scid defect affects the final step of the immunoglobulin VDJ recombinase mechanism

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980618-4

7 January 2021

The V(D)J recombination defect in the xrs-6 cell line results from a point mutation in the Ku80 gene

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980618-4

7 January 2021

RAG-1-deficient mice have no mature B and T lymphocytes

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980618-4

7 January 2021

Hypersensitivity of Ku80-deficient cell lines and mice to DNA damage: the effects of ionizing radiation on growth, survival, and development

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980618-4

7 January 2021

RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980618-4

7 January 2021

Ku70 is required for DNA repair but not for T cell antigen receptor gene recombination In vivo

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980618-4

7 January 2021

V(D)J recombination in mammalian cell mutants defective in DNA double-strand break repair

1 reference

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7 January 2021

Characterization of two DNA double-stranded break repair-deficient cell lines that express inactive DNA-dependent protein kinase catalytic subunits

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980618-4

7 January 2021

T-cell receptor gene rearrangements in functional T-cell clones from severe combined immune deficient (scid) mice: reversion of the scid phenotype in individual lymphocyte progenitors

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980618-4

7 January 2021

Molecular and biochemical characterisation of DNA-dependent protein kinase-defective rodent mutant irs-20

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980618-4

7 January 2021

Specificity in V(D)J recombination: new lessons from biochemistry and genetics

1 reference

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7 January 2021

Involvement of the Ku autoantigen in the cellular response to DNA double-strand breaks

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980618-4

7 January 2021

Characterization of broken DNA molecules associated with V(D)J recombination

1 reference

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7 January 2021

The V(D)J recombination activating gene, RAG-1.

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980618-4

7 January 2021

Activation of immunoglobulin kappa gene rearrangement correlates with induction of germline kappa gene transcription

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980618-4

7 January 2021

Virus-transformed pre-B cells show ordered activation but not inactivation of immunoglobulin gene rearrangement and transcription

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980618-4

7 January 2021

Double-strand signal sequence breaks in V(D)J recombination are blunt, 5'-phosphorylated, RAG-dependent, and cell cycle regulated

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980618-4

7 January 2021

RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980618-4

7 January 2021

Molecular and biochemical characterization of xrs mutants defective in Ku80.

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980618-4

7 January 2021

Restoration of X-ray resistance and V(D)J recombination in mutant cells by Ku cDNA.

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980618-4

7 January 2021

Potential targets for autosomal SCID mutations

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980618-4

7 January 2021

Impairment of V(D)J recombination in double-strand break repair mutants

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980618-4

7 January 2021

Ku80: product of the XRCC5 gene and its role in DNA repair and V(D)J recombination

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980618-4

7 January 2021

Somatic generation of antibody diversity

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980618-4

7 January 2021

Developmental regulation of V(D)J recombination and lymphocyte differentiation

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980618-4

7 January 2021

Interaction of DNA-dependent protein kinase with DNA and with Ku: biochemical and atomic-force microscopy studies

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980618-4

7 January 2021

Ku86-deficient mice exhibit severe combined immunodeficiency and defective processing of V(D)J recombination intermediates

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980618-4

7 January 2021

Thymocyte differentiation in gamma-irradiated severe-combined immunodeficient mice: characterization of intermediates and products of V(D)J recombination at the T cell receptor alpha locus

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980618-4

7 January 2021

Sublethal gamma-radiation induces differentiation of CD4-/CD8- into CD4+/CD8+ thymocytes without T cell receptor beta rearrangement in recombinase activation gene 2-/- mice

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980618-4

7 January 2021

10.1016/S1074-7613(00)80618-4

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9768755%20AND%20SRC:MED&resulttype=core&format=json

5 December 2019

2 references

24 January 2017