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Somatic generation of antibody diversity
scientific article (publication date: 14 April 1983)
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scholarly article
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review article
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Europe PubMed Central
title
Somatic generation of antibody diversity
(English)
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stated in
PubMed
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=6300689
retrieved
30 April 2017
main subject
antibody
1 reference
based on heuristic
inferred from title
author name string
Tonegawa S
series ordinal
1
1 reference
stated in
PubMed
reference URL
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retrieved
30 April 2017
language of work or name
English
1 reference
stated in
PubMed
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=6300689
retrieved
30 April 2017
publication date
14 April 1983
1 reference
stated in
PubMed
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=6300689
retrieved
30 April 2017
published in
Nature
1 reference
stated in
PubMed
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=6300689
retrieved
30 April 2017
volume
302
1 reference
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PubMed
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=6300689
retrieved
30 April 2017
page(s)
575-81
1 reference
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PubMed
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=6300689
retrieved
30 April 2017
issue
5909
1 reference
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PubMed
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=6300689
retrieved
30 April 2017
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THE NATURAL-SELECTION THEORY OF ANTIBODY FORMATION
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7 January 2021
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The somatic generation of immune recognition
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Selection under a somatic model
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7 January 2021
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An analysis of the sequences of the variable regions of Bence Jones proteins and myeloma light chains and their implications for antibody complementarity
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7 January 2021
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Three-dimensional structure of immunoglobulins
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7 January 2021
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The molecular basis of antibody formation: a paradox
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7 January 2021
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Evidence for somatic rearrangement of immunoglobulin genes coding for variable and constant regions
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7 January 2021
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Cloning of an immunoglobulin variable region gene from mouse embryo
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7 January 2021
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Variable and constant parts of the immunoglobulin light chain gene of a mouse myeloma cell are 1250 nontranslated bases apart
1 reference
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Crossref
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7 January 2021
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Sequence of a mouse germ-line gene for a variable region of an immunoglobulin light chain
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Crossref
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7 January 2021
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Multiple related immunoglobulin variable-region genes identified by cloning and sequence analysis
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Crossref
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7 January 2021
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Evidence for noncontiguous variable and constant region genes in both germ line and myeloma DNA
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7 January 2021
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A complete immunoglobulin gene is created by somatic recombination
1 reference
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Crossref
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https://api.crossref.org/works/10.1038%2F302575A0
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7 January 2021
based on heuristic
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DNA clones containing mouse immunoglobulin kappa chain genes isolated by in vitro packaging into phage lambda coats
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7 January 2021
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Sequences of mouse immunoglobulin light chain genes before and after somatic changes
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Crossref
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https://api.crossref.org/works/10.1038%2F302575A0
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7 January 2021
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The arrangement and rearrangement of antibody genes
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2F302575A0
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7 January 2021
based on heuristic
inferred from DOI database lookup
Sequences at the somatic recombination sites of immunoglobulin light-chain genes
1 reference
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Crossref
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7 January 2021
based on heuristic
inferred from DOI database lookup
Two types of somatic recombination are necessary for the generation of complete immunoglobulin heavy-chain genes.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2F302575A0
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7 January 2021
based on heuristic
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Sequences of five potential recombination sites encoded close to an immunoglobulin kappa constant region gene
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2F302575A0
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7 January 2021
based on heuristic
inferred from DOI database lookup
An immunoglobulin heavy chain variable region gene is generated from three segments of DNA: VH, D and JH.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2F302575A0
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7 January 2021
based on heuristic
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Contribution of immunoglobulin heavy-chain variable-region genes to antibody diversity.
1 reference
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Crossref
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7 January 2021
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Human immunoglobulin kappa light-chain genes are deleted or rearranged in lambda-producing B cells
1 reference
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Crossref
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7 January 2021
based on heuristic
inferred from DOI database lookup
Rat kappa-chain J-segment genes: Two recent gene duplications separate rat and mouse
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2F302575A0
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7 January 2021
based on heuristic
inferred from DOI database lookup
Structure and multiplicity of genes for the human immunoglobulin heavy chain variable region
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2F302575A0
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7 January 2021
based on heuristic
inferred from DOI database lookup
Chromosomal location of structural genes encoding murine immunoglobulin lambda light chains. Genetics of murine lambda light chains
1 reference
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Crossref
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7 January 2021
based on heuristic
inferred from DOI database lookup
Assignment of genes for immunoglobulin kappa and heavy chains to chromosomes 6 and 12 in mouse
1 reference
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Crossref
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7 January 2021
based on heuristic
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Chromosomal assignment of the mouse kappa light chain genes
1 reference
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Crossref
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7 January 2021
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inferred from DOI database lookup
Linkage analyses of murine immunoglobulin heavy chain and serum prealbumin genes establish their location on chromosome 12 proximal to the T (5;12) 31H breakpoint in band 12F1.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2F302575A0
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7 January 2021
based on heuristic
inferred from DOI database lookup
Chromosomal location of the structural gene cluster encoding murine immunoglobulin heavy chains
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2F302575A0
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7 January 2021
based on heuristic
inferred from DOI database lookup
Organization of four mouse lambda light chain immunoglobulin genes
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2F302575A0
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7 January 2021
based on heuristic
inferred from DOI database lookup
DNA sequences of the joining regions of mouse lambda light chain immunoglobulin genes
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2F302575A0
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7 January 2021
based on heuristic
inferred from DOI database lookup
Structural alterations in J regions of mouse immunoglobulin lambda genes are associated with differential gene expression.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2F302575A0
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7 January 2021
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inferred from DOI database lookup
Characterization of a mouse DNA clone containing an immunoglobulin variable region gene
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2F302575A0
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7 January 2021
based on heuristic
inferred from DOI database lookup
Variability in the Lambda Light Chain Sequences of Mouse Antibody
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2F302575A0
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7 January 2021
based on heuristic
inferred from DOI database lookup
Identification of a third type of lambda light chain in mouse immunoglobulins
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2F302575A0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Unusual association of V, J and C regions in a mouse immunoglobulin lambda chain
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2F302575A0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Antibody diversity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F302575A0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identical 3' non-coding sequences in five mouse Ig kappa chain mRNAs favour a unique C kappa gene
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F302575A0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Rearrangement of genetic information may produce immunoglobulin diversity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F302575A0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Amino acid sequence of homogeneous antibodies to dextran and DNA rearrangements in heavy chain V-region gene segments
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F302575A0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identification and nucleotide sequence of a diversity DNA segment (D) of immunoglobulin heavy-chain genes.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F302575A0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identification of D segments of immunoglobulin heavy-chain genes and their rearrangement in T lymphocytes.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F302575A0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Organization, structure, and assembly of immunoglobulin heavy chain diversity DNA segments
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F302575A0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Diversity of germ-line immunoglobulin VH genes.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F302575A0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Sequences of the joining region genes for immunoglobulin heavy chains and their role in generation of antibody diversity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F302575A0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mouse immunoglobulin D: messenger RNA and genomic DNA sequences.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F302575A0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Linkage of the four gamma subclass heavy chain genes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F302575A0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The role of DNA rearrangement and alternative RNA processing in the expression of immunoglobulin delta genes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F302575A0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Organization of the constant-region gene family of the mouse immunoglobulin heavy chain
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F302575A0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Domains and the hinge region of an immunoglobulin heavy chain are encoded in separate DNA segments
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F302575A0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Immunoglobulin heavy chain gene organization in mice: analysis of a myeloma genomic clone containing variable and alpha constant regions
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F302575A0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Two mRNAs with different 3' ends encode membrane-bound and secreted forms of immunoglobulin mu chain
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F302575A0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Two mRNAs can be produced from a single immunoglobulin mu gene by alternative RNA processing pathways
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F302575A0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Synthesis of secreted and membrane-bound immunoglobulin mu heavy chains is directed by mRNAs that differ at their 3' ends
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F302575A0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Expression of IgD may use both DNA rearrangement and RNA splicing mechanisms
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F302575A0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Simultaneous expression of immunoglobulin mu and delta heavy chains by a cloned B-cell lymphoma: a single copy of the VH gene is shared by two adjacent CH genes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F302575A0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
An immunoglobulin heavy-chain gene is formed by at least two recombinational events
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F302575A0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Exon shuffling generates an immunoglobulin heavy chain gene
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F302575A0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Structure of a rearranged gamma 1 chain gene and its implication to immunoglobulin class-switch mechanism
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F302575A0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Repetitive sequences in class-switch recombination regions of immunoglobulin heavy chain genes.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F302575A0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Immunoglobulin heavy-chain constant-region genes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F302575A0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The joining of V and J gene segments creates antibody diversity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F302575A0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Functional and non-functional joining in immunoglobulin light chain genes of a mouse myeloma.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F302575A0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Variation in the crossover point of kappa immunoglobulin gene V-J recombination: evidence from a cryptic gene
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F302575A0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Misalignment of V and J gene segments resulting in a nonfunctional immunoglobulin gene
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F302575A0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
RNA splicing mutation in an aberrantly rearranged immunoglobulin lambda I gene
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F302575A0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Joining of immunoglobulin heavy chain gene segments: implications from a chromosome with evidence of three D-JH fusions
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F302575A0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Allelic exclusion and nonproductive immunoglobulin gene rearrangements
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F302575A0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Somatic Changes in the Content and Context of Immunoglobulin Genes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F302575A0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Recombined flanks of the variable and joining segments of immunoglobulin genes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F302575A0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
DNA between variable and joining gene segments of immunoglobulin kappa light chain is frequently retained in cells that rearrange the kappa locus
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F302575A0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Immunoglobulin V/J recombination is accompanied by deletion of joining site and variable region segments
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F302575A0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A rearranged DNA sequence possibly related to the translocation of immunoglobulin gene segments
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F302575A0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Continuing kappa-gene rearrangement in a cell line transformed by Abelson murine leukemia virus
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F302575A0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A novel type of aberrant recombination in immunoglobulin genes and its implications for V-J joining mechanism.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F302575A0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A possible genetic basis for specific pattern in antibody.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F302575A0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Genes and antibodies
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F302575A0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Origin of Antibody Variation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F302575A0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mechanism of antibody diversity: germ line basis for variability
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F302575A0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Somatic translocation of antibody genes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F302575A0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Crossover Model of Antibody Variability
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F302575A0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Antibody variability. Somatic recombination between the elements of "antibody gene pairs" may explain antibody variability
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F302575A0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Genetic Control of Antibody Variable Regions
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F302575A0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Somatic mutation of immunoglobulin light-chain variable-region genes.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F302575A0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Somatic diversification is required to generate the V kappa genes of MOPC 511 and MOPC 167 myeloma proteins
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F302575A0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mechanisms of antibody diversity: Multiple genes encode structurally related mouse κ variable regions
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F302575A0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Multiplicity of germline genes specifying a group of related mouse κ chains with implications for the generation of immunoglobulin diversity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F302575A0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
IgG antibodies to phosphorylcholine exhibit more diversity than their IgM counterparts
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F302575A0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A single VH gene segment encodes the immune response to phosphorylcholine: somatic mutation is correlated with the class of the antibody.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F302575A0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Antibody diversity: somatic hypermutation of rearranged VH genes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F302575A0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Heavy chain variable region contribution to the NPb family of antibodies: somatic mutation evident in a gamma 2a variable region
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F302575A0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Gene conversion: some implications for immunoglobulin genes
1 reference
stated in
Crossref
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https://api.crossref.org/works/10.1038%2F302575A0
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7 January 2021
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Immunoglobulin V region variants in hybridoma cells. II. Recombination between V genes.
1 reference
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Crossref
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https://api.crossref.org/works/10.1038%2F302575A0
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7 January 2021
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Multiple differences between the nucleic acid sequences of the IgG2aa and IgG2ab alleles of the mouse
1 reference
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Crossref
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7 January 2021
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Dual expression of λ genes in the MOPC-315 plasmacytoma
1 reference
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Crossref
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7 January 2021
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Differences between germ-line and rearranged immunoglobulin Vκ coding sequences suggest a localized mutation mechanism
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2F302575A0
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7 January 2021
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Cloning and sequence of the cDNA corresponding to the variable region of immunoglobulin heavy chain MPC11
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F302575A0
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7 January 2021
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Two Types of DNA Rearrangements in Immunoglobulin Genes
1 reference
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Crossref
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7 January 2021
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Organization and reorganization of immunoglobulin heavy-chain genes
1 reference
stated in
Crossref
reference URL
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7 January 2021
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Immunoglobulin gene rearrangements in normal mouse B cells
1 reference
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Crossref
reference URL
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7 January 2021
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Association of allotypic specificities of group a with allotypic specificities A11 and A12 in rabbit immunoglobulin
1 reference
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Crossref
reference URL
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7 January 2021
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Somatic mutation gains its place among the generators of diversity
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7 January 2021
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Identifiers
DOI
10.1038/302575A0
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
727769
Dimensions Publication ID
1025246621
0 references
OpenCitations bibliographic resource ID
727769
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
727769
PubMed ID
6300689
2 references
stated in
PubMed
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=6300689
retrieved
30 April 2017
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
727769
ResearchGate publication ID
16894973
0 references
Springer Nature article ID
10.1038/302575a0
0 references
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