(Q35170919)

6 August 2017

1 reference

title

The role of DNA breaks in genomic instability and tumorigenesis (English)

1 reference

6 August 2017

Kevin D Mills

1

1 reference

6 August 2017

David O Ferguson

series ordinal

2

1 reference

6 August 2017

Frederick W Alt

series ordinal

3

1 reference

6 August 2017

publication date

1 August 2003

1 reference

6 August 2017

published in

Immunological Reviews

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6 August 2017

volume

194

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6 August 2017

page(s)

77-95

1 reference

DNA double-strand breaks: signaling, repair and the cancer connection

6 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

DNA double strand break repair and chromosomal translocation: lessons from animal models

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

The mechanism and regulation of chromosomal V(D)J recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

Factors and forces controlling V(D)J recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

The RAG proteins and V(D)J recombination: complexes, ends, and transposition

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

Developmental regulation of V(D)J recombination and lymphocyte differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

Molecular determinants of TCR expression and selection.

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

Regulation of RAG expression in developing lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

V(D)J recombination and the cell cycle.

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

Revising B cell receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

Tying loose ends: roles of Ku and DNA-dependent protein kinase in the repair of double-strand breaks

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

The Greek Goddess, Artemis, reveals the secrets of her cleavage

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

How to make ends meet in V(D)J recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

Ku recruits the XRCC4-ligase IV complex to DNA ends

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

Does artemis end the hunt for the hairpin-opening activity in V(D)J recombination?

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

A founder mutation in Artemis, an SNM1-like protein, causes SCID in Athabascan-speaking Native Americans

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

Artemis, a novel DNA double-strand break repair/V(D)J recombination protein, is mutated in human severe combined immune deficiency.

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

A human severe combined immunodeficiency (SCID) condition with increased sensitivity to ionizing radiations and impaired V(D)J rearrangements defines a new DNA recombination/repair deficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

Leaky Scid phenotype associated with defective V(D)J coding end processing in Artemis-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

Hairpin opening and overhang processing by an Artemis/DNA-dependent protein kinase complex in nonhomologous end joining and V(D)J recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

Defective DNA repair and increased genomic instability in Artemis-deficient murine cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

Signal joint formation is also impaired in DNA-dependent protein kinase catalytic subunit knockout cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

Catalytic subunit of DNA-dependent protein kinase: impact on lymphocyte development and tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

A critical role for DNA end-joining proteins in both lymphogenesis and neurogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

Late embryonic lethality and impaired V(D)J recombination in mice lacking DNA ligase IV

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

Defective embryonic neurogenesis in Ku-deficient but not DNA-dependent protein kinase catalytic subunit-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

The embryonic lethality in DNA ligase IV-deficient mice is rescued by deletion of Ku: implications for unifying the heterogeneous phenotypes of NHEJ mutants

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

DNA ligase IV deficiency in mice leads to defective neurogenesis and embryonic lethality via the p53 pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

Interplay of p53 and DNA-repair protein XRCC4 in tumorigenesis, genomic stability and development

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

DNA repair protein Ku80 suppresses chromosomal aberrations and malignant transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

Mechanism and control of class-switch recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

Unique and unprecedented recombination mechanisms in class switching

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

Ku80 is required for immunoglobulin isotype switching

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

Ku70 is required for late B cell development and immunoglobulin heavy chain class switching

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

Specific expression of activation-induced cytidine deaminase (AID), a novel member of the RNA-editing deaminase family in germinal center B cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2)

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

Immunoglobulin genes: generating diversity with AID and UNG.

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

Immunoglobulin isotype switching is inhibited and somatic hypermutation perturbed in UNG-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

Transcription-targeted DNA deamination by the AID antibody diversification enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

Ablation of XRCC2/3 transforms immunoglobulin V gene conversion into somatic hypermutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

Altering the pathway of immunoglobulin hypermutation by inhibiting uracil-DNA glycosylase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

DNA double-strand breaks: prior to but not sufficient in targeting hypermutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

The activation-induced deaminase functions in a postcleavage step of the somatic hypermutation process

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

The function of AID in somatic mutation and class switch recombination: upstream or downstream of DNA breaks

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

DNA-dependent protein kinase activity is not required for immunoglobulin class switching

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

Somatic hypermutation in the absence of DNA-dependent protein kinase catalytic subunit (DNA-PK(cs)) or recombination-activating gene (RAG)1 activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

Requirement of the activation-induced deaminase (AID) gene for immunoglobulin gene conversion

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

Genetic and environmental factors in cancer and neurodegenerative diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

How DNA lesions are turned into mutations within cells?

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

Induction of multiple double-strand breaks within an hsr by meganucleaseI-SceI expression or fragile site activation leads to formation of double minutes and other chromosomal rearrangements

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

Protection of mammalian telomeres

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

New ways not to make ends meet: telomerase, DNA damage proteins and heterochromatin

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

Ku acts in a unique way at the mammalian telomere to prevent end joining

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

Mammalian Ku86 protein prevents telomeric fusions independently of the length of TTAGGG repeats and the G-strand overhang

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

Ku is associated with the telomere in mammals

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

Functional interaction between DNA-PKcs and telomerase in telomere length maintenance

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

Phorbol myristate acetate and Bryostatin 1 rescue IFN-gamma inducibility of MHC class II molecules in LS1034 colorectal carcinoma cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

DNA ligase IV-dependent NHEJ of deprotected mammalian telomeres in G1 and G2

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

A second B cell-specific enhancer 3' of the immunoglobulin heavy-chain locus

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

The biology of chronic myeloid leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

Modeling Philadelphia chromosome positive leukemias

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

Proteins encoded by genes involved in chromosomal alterations in lymphoma and leukemia: clinical value of their detection by immunocytochemistry

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

Molecular mechanisms of leukemogenesis mediated by MLL fusion proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

Molecular biology of lymphoid malignancies

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

Assessing the pathogenic potential of the V(D)J recombinase by interlocus immunoglobulin light-chain gene rearrangement

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

Amplification of oncogenes in human cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

Oncogene amplification in solid tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

Gene amplification in a p53-deficient cell line requires cell cycle progression under conditions that generate DNA breakage

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

Wild-type p53 restores cell cycle control and inhibits gene amplification in cells with mutant p53 alleles.

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

The RAG-1/2 endonuclease causes genomic instability and controls CNS complications of lymphoblastic leukemia in p53/Prkdc-deficient mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

Unrepaired DNA breaks in p53-deficient cells lead to oncogenic gene amplification subsequent to translocations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

Evidence for replicative repair of DNA double-strand breaks leading to oncogenic translocation and gene amplification

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

Evaluation of ETF1/eRF1, mapping to 5q31, as a candidate myeloid tumor suppressor gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

Chromosome aberrations in B-cell chronic lymphocytic leukemia: reassessment based on molecular cytogenetic analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

Comprehensive analysis of a large genomic sequence at the putative B-cell chronic lymphocytic leukaemia (B-CLL) tumour suppresser gene locus

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

Mechanisms of chromosomal translocations in B cell lymphomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

Chromosomal translocations in lymphoid malignancies reveal novel proto-oncogenes

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

Insight into Burkitt's lymphoma from immunoglobulin variable region gene analysis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

Molecular insights into the immunopathogenesis of follicular lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

Cellular origin of human B-cell lymphomas.

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

Follicular lymphoma: a model of lymphoid tumor progression in man.

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

The proto-oncogene BCL-6 in normal and malignant B cell development

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

BCL-6 and the Molecular Pathogenesis of B-Cell Lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

Molecular mechanisms involved in receptor editing at the Ig heavy chain locus

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

Jumping translocations are common in solid tumor cell lines and result in recurrent fusions of whole chromosome arms

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

Transposition and amplification of oncogene-related sequences in human neuroblastomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

Segmental amplification of 11q23 region identified by fluorescence in situ hybridization in four patients with myeloid disorders: a review

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

Double minute chromosomes in acute myeloid leukemia and myelodysplastic syndrome: identification of new amplification regions by fluorescence in situ hybridization and spectral karyotyping

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

Identification of cytogenetic subclasses and recurring chromosomal aberrations in AML and MDS with complex karyotypes using M-FISH.

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

Compilation of published comparative genomic hybridization studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

Multiple myeloma: evolving genetic events and host interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

Genetic variants of NHEJ DNA ligase IV can affect the risk of developing multiple myeloma, a tumour characterised by aberrant class switch recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

Analysis of ku80-mutant mice and cells with deficient levels of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

The XRCC4 gene encodes a novel protein involved in DNA double-strand break repair and V(D)J recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

Different types of V(D)J recombination and end-joining defects in DNA double-strand break repair mutant mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

Growth retardation and leaky SCID phenotype of Ku70-deficient mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

Cyclin A/CDK2 regulates V(D)J recombination by coordinating RAG-2 accumulation and DNA repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

Cancer. p53, guardian of the genome

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

Genetic instabilities in human cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

Frequent chromosomal translocations induced by DNA double-strand breaks

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

Interstitial deletions and intrachromosomal amplification initiated from a double-strand break targeted to a mammalian chromosome

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

Amplification of the human dihydrofolate reductase gene via double minutes is initiated by chromosome breaks

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

Human cancer: etiologic agents/dose responses/DNA repair/cellular and animal models

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

The Fanconi anaemia/BRCA pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

Recombinational DNA repair and human disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

Chromosome instability syndromes

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

DNA ligase IV mutations identified in patients exhibiting developmental delay and immunodeficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

Partial T and B lymphocyte immunodeficiency and predisposition to lymphoma in patients with hypomorphic mutations in Artemis

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

A variant of the DNA repair gene XRCC3 and risk of squamous cell carcinoma of the head and neck: a case-control analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

Variants in DNA double-strand break repair genes and breast cancer susceptibility

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

A potential role for the XRCC2 R188H polymorphic site in DNA-damage repair and breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

Continued RAG expression in late stages of B cell development and no apparent re-induction after immunizion

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

Regulation of immunoglobulin light chain isotype expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

7 January 2021

RAG2:GFP Knockin Mice Reveal Novel Aspects of RAG2 Expression in Primary and Peripheral Lymphoid Tissues

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

7 January 2021

Impairment of V(D)J recombination in double-strand break repair mutants

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

7 January 2021

Ku autoantigen: a multifunctional DNA-binding protein

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

7 January 2021

DNA end-joining: from yeast to man

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

7 January 2021

A targeted DNA-PKcs-null mutation reveals DNA-PK-independent functions for KU in V(D)J recombination

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

7 January 2021

Targeted disruption of the catalytic subunit of the DNA-PK gene in mice confers severe combined immunodeficiency and radiosensitivity

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

7 January 2021

Targeted disruption of the gene encoding DNA ligase IV leads to lethality in embryonic mice

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

7 January 2021

Nonhomologous end-joining proteins are required for V(D)J recombination, normal growth, and neurogenesis

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

7 January 2021

The SCID but not the RAG-2 gene product is required for S mu-S epsilon heavy chain class switching.

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

7 January 2021

Somatic hypermutation of immunoglobulin genes: merging mechanisms for genetic diversity

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

7 January 2021

Somatic hypermutation, transcription, and DNA mismatch repair

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

7 January 2021

A novel cytidine deaminase affects antibody diversity

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

7 January 2021

DNA Double-Strand Breaks in Immunoglobulin Genes Undergoing Somatic Hypermutation

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

7 January 2021

IgH class switch recombination to IgG1 in DNA-PKcs-deficient B cells

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

7 January 2021

Human chromosomal fragile site FRA16B is an amplified AT-rich minisatellite repeat

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

7 January 2021

ATR Regulates Fragile Site Stability

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

7 January 2021

A role for common fragile site induction in amplification of human oncogenes

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

7 January 2021

A new role for hypoxia in tumor progression: induction of fragile site triggering genomic rearrangements and formation of complex DMs and HSRs

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

7 January 2021

Expression of fragile sites triggers intrachromosomal mammalian gene amplification and sets boundaries to early amplicons

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

7 January 2021

p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

7 January 2021

c-myc-induced lymphomagenesis in transgenic mice and the role of the Pvt-1 locus in lymphoid neoplasia.

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

7 January 2021

The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

7 January 2021

Enforced BCL2 expression in B-lymphoid cells prolongs antibody responses and elicits autoimmune disease

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

7 January 2021

The 3' IgH regulatory region: a complex structure in a search for a function

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

7 January 2021

A class switch control region at the 3′ end of the immunoglobulin heavy chain locus

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

7 January 2021

Localization of the 3' IgH locus elements that effect long-distance regulation of class switch recombination

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

7 January 2021

Identification of a locus control region in the immunoglobulin heavy-chain locus that deregulates c-myc expression in plasmacytoma and Burkitt's lymphoma cells

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

7 January 2021

p53-dependent growth arrest of REF52 cells containing newly amplified DNA.

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

7 January 2021

Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

7 January 2021

A role for secondary V(D)J recombination in oncogenic chromosomal translocations?

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

7 January 2021

VDJ recombination: a transposase goes to work

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

7 January 2021

Molecular biology of Burkitt's lymphoma

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

7 January 2021

Novel insights into the mechanism of t(14;18)(q32;q21) translocation in follicular lymphoma

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

7 January 2021

Expression of human recombination activating genes (RAG-1 and RAG-2) in lymphoma

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

7 January 2021

Clonal evolution of a follicular lymphoma: evidence for antigen selection

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

7 January 2021

Immunoglobulin gene associated chromosomal translocations in B-cell derived tumors.

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

7 January 2021

Plasmacytomagenesis in mice: model of neoplastic development dependent upon chromosomal translocations

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

7 January 2021

Nonrandom chromosome changes involving the Ig gene-carrying chromosomes 12 and 6 in pristane-induced mouse plasmacytomas

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

7 January 2021

Jumping translocation of chromosome 14 in a skin squamous cell carcinoma from a xeroderma pigmentosum patient

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

7 January 2021

Segmental jumping translocation in leukemia and lymphoma with a highly complex karyotype

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

7 January 2021

Activated expression of the N-myc gene in human neuroblastomas and related tumors

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

7 January 2021

Amplified DNA with limited homology to myc cellular oncogene is shared by human neuroblastoma cell lines and a neuroblastoma tumour

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

7 January 2021

Association of multiple copies of the N-myc oncogene with rapid progression of neuroblastomas

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

7 January 2021

Amplification of the MLL gene on double minutes, a homogeneously staining region, and ring chromosomes in five patients with acute myeloid leukemia or myelodysplastic syndrome

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

7 January 2021

Amplification of the AML1(CBFA2) gene on ring chromosomes in a patient with acute myeloid leukemia and a constitutional ring chromosome 21

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

7 January 2021

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

1 reference

7 January 2021

Molecular aspects of multiple myeloma

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

7 January 2021

Genetic pathway to recurrent chromosome translocations in murine lymphoma involves V(D)J recombinase

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

7 January 2021

Mutations in the p53 and SCID genes cooperate in tumorigenesis.

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

7 January 2021

V(D)J Recombination in Ku86-Deficient Mice: Distinct Effects on Coding, Signal, and Hybrid Joint Formation

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

7 January 2021

BRCA1 facilitates microhomology-mediated end joining of DNA double strand breaks

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

7 January 2021

Ku70: a candidate tumor suppressor gene for murine T cell lymphoma

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

7 January 2021

DNA-PKcs: a T-cell tumour suppressor encoded at the mouse scid locus

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

7 January 2021

Tumor spectrum analysis in p53-mutant mice

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

7 January 2021

p53: good cop/bad cop.

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

7 January 2021

Impaired nonhomologous end-joining provokes soft tissue sarcomas harboring chromosomal translocations, amplifications, and deletions

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00060.X

7 January 2021

10.1034/J.1600-065X.2003.00060.X

Identifiers

DOI

1 reference

6 August 2017

1 reference