(Q53965557)

23 May 2018

title

Unrepaired DNA breaks in p53-deficient cells lead to oncogenic gene amplification subsequent to translocations. (English)

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23 May 2018

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Chengming Zhu

1

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23 May 2018

Kevin D Mills

2

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23 May 2018

David O Ferguson

3

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23 May 2018

Charles Lee

4

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23 May 2018

John Manis

5

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23 May 2018

James Fleming

6

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23 May 2018

Yijie Gao

7

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23 May 2018

Cynthia C Morton

8

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23 May 2018

Frederick W Alt

9

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23 May 2018

language of work or name

English

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publication date

1 June 2002

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23 May 2018

published in

Cell

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23 May 2018

volume

109

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23 May 2018

issue

7

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23 May 2018

page(s)

811-821

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23 May 2018

The mechanism and regulation of chromosomal V(D)J recombination

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Variant (6;15) translocations in murine plasmacytomas involve a chromosome 15 locus at least 72 kb from the c-myc oncogene

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Disruption of mouse RAD54 reduces ionizing radiation resistance and homologous recombination.

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DNA double strand break repair and chromosomal translocation: lessons from animal models

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Late embryonic lethality and impaired V(D)J recombination in mice lacking DNA ligase IV

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DNA ligase IV deficiency in mice leads to defective neurogenesis and embryonic lethality via the p53 pathway

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The initiation of B cell clonal expansion occurs independently of pre-B cell receptor formation

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Multiple myeloma: evolving genetic events and host interactions

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7 January 2021

Chromosome breakage at a major fragile site associated with P-glycoprotein gene amplification in multidrug-resistant CHO cells

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7 January 2021

Cancer. p53, guardian of the genome

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7 January 2021

Cyclin A/CDK2 regulates V(D)J recombination by coordinating RAG-2 accumulation and DNA repair

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7 January 2021

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7 January 2021

Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53

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7 January 2021

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7 January 2021

Sister chromatid fusion initiates amplification of the dihydrofolate reductase gene in Chinese hamster cells

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7 January 2021

Mechanism and control of class-switch recombination

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7 January 2021

t(11;22)(q23;q11.2) In acute myeloid leukemia of infant twins fuses MLL with hCDCrel, a cell division cycle gene in the genomic region of deletion in DiGeorge and velocardiofacial syndromes

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7 January 2021

Jumping translocations are common in solid tumor cell lines and result in recurrent fusions of whole chromosome arms

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7 January 2021

Gene amplification in a p53-deficient cell line requires cell cycle progression under conditions that generate DNA breakage

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7 January 2021

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7 January 2021

Interstitial deletions and intrachromosomal amplification initiated from a double-strand break targeted to a mammalian chromosome

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7 January 2021

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7 January 2021

Frequent chromosomal translocations induced by DNA double-strand breaks

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7 January 2021

Nonhomologous recombination in mammalian cells: role for short sequence homologies in the joining reaction

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7 January 2021

Oncogene amplification in solid tumors

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7 January 2021

Impaired nonhomologous end-joining provokes soft tissue sarcomas harboring chromosomal translocations, amplifications, and deletions

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7 January 2021

RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement

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7 January 2021

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7 January 2021

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7 January 2021

Impairment of V(D)J recombination in double-strand break repair mutants

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7 January 2021

Genetic pathway to recurrent chromosome translocations in murine lymphoma involves V(D)J recombinase

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7 January 2021

Different types of V(D)J recombination and end-joining defects in DNA double-strand break repair mutant mammalian cells

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7 January 2021

A central role for chromosome breakage in gene amplification, deletion formation, and amplicon integration

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7 January 2021

Wild-type p53 restores cell cycle control and inhibits gene amplification in cells with mutant p53 alleles.

1 reference

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7 January 2021

10.1016/S0092-8674(02)00770-5

Identifiers

DOI

1 reference

23 May 2018

1 reference

23 May 2018