(Q28506076)

24 January 2017

title

DNA ligase IV deficiency in mice leads to defective neurogenesis and embryonic lethality via the p53 pathway (English)

1 reference

Ligase IV, DNA, ATP-dependent

24 January 2017

main subject

1 reference

Transformation related protein 53

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

neurogenesis

1 reference

inferred from title

DNA ligase IV deficiency

1 reference

K. M. Frank

1

1 reference

24 January 2017

N. E. Sharpless

2

1 reference

24 January 2017

Y. Gao

3

1 reference

24 January 2017

J. M. Sekiguchi

4

1 reference

24 January 2017

D. O. Ferguson

5

1 reference

24 January 2017

C. Zhu

6

1 reference

24 January 2017

J. P. Manis

7

1 reference

24 January 2017

J. Horner

8

1 reference

24 January 2017

R. A. DePinho

9

1 reference

24 January 2017

F. W. Alt

10

1 reference

24 January 2017

publication date

1 June 2000

1 reference

24 January 2017

1 reference

24 January 2017

volume

5

1 reference

24 January 2017

issue

6

1 reference

24 January 2017

page(s)

993–1002

1 reference

Enhanced phosphorylation of p53 by ATM in response to DNA damage

24 January 2017

cites work

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980264-6

7 January 2021

Targeted disruption of the gene encoding DNA ligase IV leads to lethality in embryonic mice

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980264-6

7 January 2021

Novel approach to quantitative polymerase chain reaction using real-time detection: application to the detection of gene amplification in breast cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980264-6

7 January 2021

p53 is required for both radiation-induced differentiation and rescue of V(D)J rearrangement in scid mouse thymocytes

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980264-6

7 January 2021

Activation of the ATM kinase by ionizing radiation and phosphorylation of p53

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980264-6

7 January 2021

Rearranging views on neurogenesis: neuronal death in the absence of DNA end-joining proteins

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980264-6

7 January 2021

Mammalian DNA double-strand break repair protein XRCC4 interacts with DNA ligase IV

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980264-6

7 January 2021

DNA repair protein Ku80 suppresses chromosomal aberrations and malignant transformation

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980264-6

7 January 2021

A biomarker that identifies senescent human cells in culture and in aging skin in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980264-6

7 January 2021

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980264-6

7 January 2021

Late embryonic lethality and impaired V(D)J recombination in mice lacking DNA ligase IV

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980264-6

7 January 2021

A critical role for DNA end-joining proteins in both lymphogenesis and neurogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980264-6

7 January 2021

A targeted DNA-PKcs-null mutation reveals DNA-PK-independent functions for KU in V(D)J recombination

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980264-6

7 January 2021

Interplay of p53 and DNA-repair protein XRCC4 in tumorigenesis, genomic stability and development

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980264-6

7 January 2021

Recent advances in understanding V(D)J recombination.

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980264-6

7 January 2021

Cell birth, cell death, cell diversity and DNA breaks: how do they all fit together?

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980264-6

7 January 2021

Activity of DNA ligase IV stimulated by complex formation with XRCC4 protein in mammalian cells

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980264-6

7 January 2021

Growth retardation and leaky SCID phenotype of Ku70-deficient mice.

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980264-6

7 January 2021

Defective embryonic neurogenesis in Ku-deficient but not DNA-dependent protein kinase catalytic subunit-deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980264-6

7 January 2021

V(D)J recombination activates a p53-dependent DNA damage checkpoint in scid lymphocyte precursors.

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980264-6

7 January 2021

Tumor spectrum analysis in p53-mutant mice

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980264-6

7 January 2021

The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980264-6

7 January 2021

DNA-PK: at the cross-roads of biochemistry and genetics

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980264-6

7 January 2021

p53 prevents maturation to the CD4+CD8+ stage of thymocyte differentiation in the absence of T cell receptor rearrangement.

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980264-6

7 January 2021

Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980264-6

7 January 2021

Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980264-6

7 January 2021

ATM associates with and phosphorylates p53: mapping the region of interaction

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980264-6

7 January 2021

The ataxia-telangiectasia related protein ATR mediates DNA-dependent phosphorylation of p53.

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980264-6

7 January 2021

p53, the cellular gatekeeper for growth and division

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980264-6

7 January 2021

No requirement for V(D)J recombination in p53-deficient thymic lymphoma

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980264-6

7 January 2021

The biochemistry and biological significance of nonhomologous DNA end joining: an essential repair process in multicellular eukaryotes

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980264-6

7 January 2021

RAG-1-deficient mice have no mature B and T lymphocytes

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980264-6

7 January 2021

Mutations in the p53 and SCID genes cooperate in tumorigenesis.

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980264-6

7 January 2021

Requirement for Ku80 in growth and immunoglobulin V(D)J recombination

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980264-6

7 January 2021

Ku70 is required for DNA repair but not for T cell antigen receptor gene recombination In vivo

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980264-6

7 January 2021

Gene amplification in a p53-deficient cell line requires cell cycle progression under conditions that generate DNA breakage

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980264-6

7 January 2021

The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980264-6

7 January 2021

Nonhomologous end-joining proteins are required for V(D)J recombination, normal growth, and neurogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980264-6

7 January 2021

Role of the INK4a locus in tumor suppression and cell mortality.

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980264-6

7 January 2021

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980264-6

7 January 2021

Tumor surveillance via the ARF-p53 pathway.

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980264-6

7 January 2021

RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980264-6

7 January 2021

The DNA-dependent protein kinase

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980264-6

7 January 2021

The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2.

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980264-6

7 January 2021

Neonatal lethality with abnormal neurogenesis in mice deficient in DNA polymerase beta

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980264-6

7 January 2021

Impairment of V(D)J recombination in double-strand break repair mutants

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980264-6

7 January 2021

Targeted disruption of the catalytic subunit of the DNA-PK gene in mice confers severe combined immunodeficiency and radiosensitivity

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980264-6

7 January 2021

A role for ATR in the DNA damage-induced phosphorylation of p53

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980264-6

7 January 2021

Structure and function of mammalian DNA ligases

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980264-6

7 January 2021

T cell receptor (TCR)-beta gene recombination: dissociation from cell cycle regulation and developmental progression during T cell ontogeny

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980264-6

7 January 2021

Genetic pathway to recurrent chromosome translocations in murine lymphoma involves V(D)J recombinase

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980264-6

7 January 2021

Developmental regulation of V(D)J recombination and lymphocyte differentiation

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980264-6

7 January 2021

A striking organization of a large family of human neural cadherin-like cell adhesion genes

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980264-6

7 January 2021

ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980264-6

7 January 2021

Ku86-deficient mice exhibit severe combined immunodeficiency and defective processing of V(D)J recombination intermediates

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980264-6

7 January 2021