(Q21495235)

DNA ligase 4

1 reference

DNA ligase, ATP-dependent, N-terminal domain superfamily

1 reference

Nucleic acid-binding, OB-fold

1 reference

DNA ligase, ATP-dependent, central domain, protein family

1 reference

DNA ligase IV domain, protein family

1 reference

DNA ligase, ATP-dependent, C-terminal domain, protein family

1 reference

DNA ligase, ATP-dependent, N-terminal domain, protein family

1 reference

BRCT domain, protein family

1 reference

DNA ligase, ATP-dependent, conserved site, protein family

1 reference

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BTF7

1 reference

25 May 2022

1 reference

25 May 2022

1 reference

14 February 2019

3 references

DNA ligase (ATP) activity

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BTF7

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BTF7

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BTF7

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BTF7

14 February 2019

Phosphorylation and regulation of DNA ligase IV stability by DNA-dependent protein kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BTF7

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BTF7

3 references

1 reference

14 February 2019

The transposase domain protein Metnase/SETMAR suppresses chromosomal translocations

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BTF7

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BTF7

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BTF7

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BTF7

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BTF7

14 February 2019

Phosphorylation and regulation of DNA ligase IV stability by DNA-dependent protein kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BTF7

2 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BTF7

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BTF7

DNA-dependent protein kinase-DNA ligase 4 complex

3 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8BTF7&geneProductId=UniProtKB:Q8BTF7

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8BTF7&geneProductId=UniProtKB:Q8BTF7

24 April 2018

Phosphorylation and regulation of DNA ligase IV stability by DNA-dependent protein kinase

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8BTF7&geneProductId=UniProtKB:Q8BTF7

nonhomologous end joining complex

IDA

DNA ligase IV complex

3 references

3 references

3 references

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8BTF7&geneProductId=UniProtKB:Q8BTF7

DNA-dependent protein kinase-DNA ligase 4 complex

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BTF7

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BTF7

14 February 2019

Phosphorylation and regulation of DNA ligase IV stability by DNA-dependent protein kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BTF7

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BTF7

negative regulation of neuron apoptotic process

biological process

3 references

14 February 2019

A critical role for DNA end-joining proteins in both lymphogenesis and neurogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BTF7

14 February 2019

Selective utilization of nonhomologous end-joining and homologous recombination DNA repair pathways during nervous system development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BTF7

14 February 2019

DNA ligase IV deficiency in mice leads to defective neurogenesis and embryonic lethality via the p53 pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BTF7

nucleotide-excision repair, DNA gap filling

IGI

3 references

neuron apoptotic process

1 reference

14 February 2019

Genetic interactions between ATM and the nonhomologous end-joining factors in genomic stability and development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BTF7

2 references

lagging strand elongation

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8BTF7&geneProductId=UniProtKB:Q8BTF7

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BTF7

DNA biosynthetic process

1 reference

14 February 2019

cellular response to lithium ion

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BTF7

somatic stem cell population maintenance

1 reference

14 February 2019

DNA repair is limiting for haematopoietic stem cells during ageing

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BTF7

T cell receptor V(D)J recombination

1 reference

14 February 2019

DNA ligase IV deficiency in mice leads to defective neurogenesis and embryonic lethality via the p53 pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BTF7

in utero embryonic development

3 references

14 February 2019

Selective utilization of nonhomologous end-joining and homologous recombination DNA repair pathways during nervous system development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BTF7

14 February 2019

Late embryonic lethality and impaired V(D)J recombination in mice lacking DNA ligase IV

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BTF7

14 February 2019

DNA ligase IV deficiency in mice leads to defective neurogenesis and embryonic lethality via the p53 pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BTF7

Rad54 and DNA Ligase IV cooperate to maintain mammalian chromatid stability

chromosome organization

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BTF7

cellular response to DNA damage stimulus

IGI

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BTF7

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BTF7

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BTF7

14 February 2019

DNA processing is not required for ATM-mediated telomere damage response after TRF2 deletion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BTF7

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BTF7

14 February 2019

Phosphorylation and regulation of DNA ligase IV stability by DNA-dependent protein kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BTF7

positive regulation of neurogenesis

IDA

3 references

14 February 2019

Defective embryonic neurogenesis in Ku-deficient but not DNA-dependent protein kinase catalytic subunit-deficient mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BTF7

14 February 2019

Selective utilization of nonhomologous end-joining and homologous recombination DNA repair pathways during nervous system development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BTF7

14 February 2019

A critical role for DNA end-joining proteins in both lymphogenesis and neurogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BTF7

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BTF7

central nervous system development

3 references

14 February 2019

A critical role for DNA end-joining proteins in both lymphogenesis and neurogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BTF7

14 February 2019

Targeted disruption of the gene encoding DNA ligase IV leads to lethality in embryonic mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BTF7

14 February 2019

DNA ligase IV deficiency in mice leads to defective neurogenesis and embryonic lethality via the p53 pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BTF7

double-strand break repair

IGI

7 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BTF7

14 February 2019

The embryonic lethality in DNA ligase IV-deficient mice is rescued by deletion of Ku: implications for unifying the heterogeneous phenotypes of NHEJ mutants

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BTF7

14 February 2019

DNA repair is limiting for haematopoietic stem cells during ageing

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BTF7

14 February 2019

Rad54 and DNA Ligase IV cooperate to maintain mammalian chromatid stability

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BTF7

14 February 2019

The embryonic lethality in DNA ligase IV-deficient mice is rescued by deletion of Ku: implications for unifying the heterogeneous phenotypes of NHEJ mutants

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BTF7

14 February 2019

Rad54 and DNA Ligase IV cooperate to maintain mammalian chromatid stability

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BTF7

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BTF7

1 reference

14 February 2019

IgH class switching and translocations use a robust non-classical end-joining pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BTF7

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BTF7

14 February 2019

Defective embryonic neurogenesis in Ku-deficient but not DNA-dependent protein kinase catalytic subunit-deficient mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BTF7

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BTF7

14 February 2019

Phosphorylation and regulation of DNA ligase IV stability by DNA-dependent protein kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BTF7

DNA ligation involved in DNA repair

IDA

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BTF7

14 February 2019

Late embryonic lethality and impaired V(D)J recombination in mice lacking DNA ligase IV

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BTF7

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BTF7

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BTF7

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BTF7

immunoglobulin V(D)J recombination

1 reference

24 April 2018

Late embryonic lethality and impaired V(D)J recombination in mice lacking DNA ligase IV

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8BTF7&geneProductId=UniProtKB:Q8BTF7

double-strand break repair via nonhomologous end joining

5 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8BTF7&geneProductId=UniProtKB:Q8BTF7

24 April 2018

The nonhomologous end-joining pathway of DNA repair is required for genomic stability and the suppression of translocations

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8BTF7&geneProductId=UniProtKB:Q8BTF7

24 April 2018

Selective utilization of nonhomologous end-joining and homologous recombination DNA repair pathways during nervous system development

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8BTF7&geneProductId=UniProtKB:Q8BTF7

24 April 2018

DNA ligase IV-dependent NHEJ of deprotected mammalian telomeres in G1 and G2

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8BTF7&geneProductId=UniProtKB:Q8BTF7

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8BTF7&geneProductId=UniProtKB:Q8BTF7

4 references

14 February 2019

Impaired nonhomologous end-joining provokes soft tissue sarcomas harboring chromosomal translocations, amplifications, and deletions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BTF7

14 February 2019

DNA ligase III is critical for mtDNA integrity but not Xrcc1-mediated nuclear DNA repair

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BTF7

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BTF7

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BTF7

2 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BTF7

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BTF7

DNA ligation involved in DNA recombination

1 reference

14 February 2019

Late embryonic lethality and impaired V(D)J recombination in mice lacking DNA ligase IV

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BTF7

double-strand break repair via nonhomologous end joining

6 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BTF7

14 February 2019

Selective utilization of nonhomologous end-joining and homologous recombination DNA repair pathways during nervous system development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BTF7

14 February 2019

The nonhomologous end-joining pathway of DNA repair is required for genomic stability and the suppression of translocations

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BTF7

14 February 2019

DNA ligase IV-dependent NHEJ of deprotected mammalian telomeres in G1 and G2

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BTF7

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BTF7

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BTF7

cellular response to ionizing radiation

1 reference

7 November 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8BTF7&geneProductId=UniProtKB:Q8BTF7

DNA ligase, ATP-dependent, conserved site

has part(s)

1 reference

DNA ligase, ATP-dependent, C-terminal

1 reference

BRCT domain

1 reference

DNA ligase IV domain

1 reference

DNA ligase, ATP-dependent, N-terminal

1 reference

DNA ligase, ATP-dependent, central domain

1 reference