(Q32067274)

6 July 2017

title

How to make ends meet in V(D)J recombination (English)

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6 July 2017

U Grawunder

1

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6 July 2017

E Harfst

series ordinal

2

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6 July 2017

publication date

1 April 2001

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Current Opinion in Immunology

6 July 2017

published in

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6 July 2017

volume

13

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6 July 2017

issue

2

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6 July 2017

page(s)

186-194

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Somatic generation of antibody diversity

6 July 2017

cites work

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2800%2900203-X

7 January 2021

Accessibility and the developmental regulation of V(D)J recombination

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2800%2900203-X

7 January 2021

A role for histone acetylation in the developmental regulation of VDJ recombination.

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2800%2900203-X

7 January 2021

Stimulation of V(D)J recombination by histone acetylation

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2800%2900203-X

7 January 2021

Recombination signal sequences restrict chromosomal V(D)J recombination beyond the 12/23 rule.

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2800%2900203-X

7 January 2021

Cleavage at a V(D)J recombination signal requires only RAG1 and RAG2 proteins and occurs in two steps.

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2800%2900203-X

7 January 2021

The V(D)J recombination activating gene, RAG-1.

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2800%2900203-X

7 January 2021

RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2800%2900203-X

7 January 2021

RAG-1-deficient mice have no mature B and T lymphocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2800%2900203-X

7 January 2021

RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2800%2900203-X

7 January 2021

Ku, a DNA repair protein with multiple cellular functions?

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2800%2900203-X

7 January 2021

The DNA-dependent protein kinase: requirement for DNA ends and association with Ku antigen

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2800%2900203-X

7 January 2021

Productive and nonproductive complexes of Ku and DNA-dependent protein kinase at DNA termini

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2800%2900203-X

7 January 2021

DNA-dependent protein kinase: DNA binding and activation in the absence of Ku

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2800%2900203-X

7 January 2021

Defective DNA-dependent protein kinase activity is linked to V(D)J recombination and DNA repair defects associated with the murine scid mutation.

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2800%2900203-X

7 January 2021

Identification of a nonsense mutation in the carboxyl-terminal region of DNA-dependent protein kinase catalytic subunit in the scid mouse

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2800%2900203-X

7 January 2021

Biochemical and genetic defects in the DNA-dependent protein kinase in murine scid lymphocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2800%2900203-X

7 January 2021

A targeted DNA-PKcs-null mutation reveals DNA-PK-independent functions for KU in V(D)J recombination

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2800%2900203-X

7 January 2021

Targeted disruption of the catalytic subunit of the DNA-PK gene in mice confers severe combined immunodeficiency and radiosensitivity

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2800%2900203-X

7 January 2021

Requirement for Ku80 in growth and immunoglobulin V(D)J recombination

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2800%2900203-X

7 January 2021

Ku86-deficient mice exhibit severe combined immunodeficiency and defective processing of V(D)J recombination intermediates

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2800%2900203-X

7 January 2021

Growth retardation and leaky SCID phenotype of Ku70-deficient mice.

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2800%2900203-X

7 January 2021

Ku70 is required for DNA repair but not for T cell antigen receptor gene recombination In vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2800%2900203-X

7 January 2021

The XRCC4 gene encodes a novel protein involved in DNA double-strand break repair and V(D)J recombination

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2800%2900203-X

7 January 2021

Activity of DNA ligase IV stimulated by complex formation with XRCC4 protein in mammalian cells

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2800%2900203-X

7 January 2021

Mammalian DNA double-strand break repair protein XRCC4 interacts with DNA ligase IV

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2800%2900203-X

7 January 2021

Late embryonic lethality and impaired V(D)J recombination in mice lacking DNA ligase IV

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2800%2900203-X

7 January 2021

A critical role for DNA end-joining proteins in both lymphogenesis and neurogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2800%2900203-X

7 January 2021

DNA end-joining: from yeast to man

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2800%2900203-X

7 January 2021

The RAG proteins and V(D)J recombination: complexes, ends, and transposition

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2800%2900203-X

7 January 2021

Cell-free V(D)J recombination

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2800%2900203-X

7 January 2021

Initiation of V(D)J recombination in a cell-free system.

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2800%2900203-X

7 January 2021

The RAG1 and RAG2 proteins establish the 12/23 rule in V(D)J recombination

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2800%2900203-X

7 January 2021

Initiation of V(D)J recombination in vitro obeying the 12/23 rule

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2800%2900203-X

7 January 2021

V(D)J recombination: modulation of RAG1 and RAG2 cleavage activity on 12/23 substrates by whole cell extract and DNA-bending proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2800%2900203-X

7 January 2021

A stable RAG1-RAG2-DNA complex that is active in V(D)J cleavage

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2800%2900203-X

7 January 2021

Rejoining of DNA by the RAG1 and RAG2 proteins.

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2800%2900203-X

7 January 2021

Transposition mediated by RAG1 and RAG2 and its implications for the evolution of the immune system

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2800%2900203-X

7 January 2021

DNA transposition by the RAG1 and RAG2 proteins: a possible source of oncogenic translocations

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2800%2900203-X

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2800%2900203-X

7 January 2021

Hairpin coding end opening is mediated by RAG1 and RAG2 proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2800%2900203-X

7 January 2021

DNA hairpin opening mediated by the RAG1 and RAG2 proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2800%2900203-X

7 January 2021

V(D)J recombination: broken DNA molecules with covalently sealed (hairpin) coding ends in scid mouse thymocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2800%2900203-X

7 January 2021

V(D)J recombination intermediates and non-standard products in XRCC4-deficient cells

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2800%2900203-X

7 January 2021

RAG1 and RAG2 form a stable postcleavage synaptic complex with DNA containing signal ends in V(D)J recombination

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2800%2900203-X

7 January 2021

Nbs1 potentiates ATP-driven DNA unwinding and endonuclease cleavage by the Mre11/Rad50 complex

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2800%2900203-X

7 January 2021

The hMre11/hRad50 protein complex and Nijmegen breakage syndrome: linkage of double-strand break repair to the cellular DNA damage response

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2800%2900203-X

7 January 2021

Nibrin, a novel DNA double-strand break repair protein, is mutated in Nijmegen breakage syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2800%2900203-X

7 January 2021

Ku80-deficient cells exhibit excess degradation of extrachromosomal DNA.

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2800%2900203-X

7 January 2021

V(D)J recombination in Ku86-deficient mice: distinct effects on coding, signal, and hybrid joint formation

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2800%2900203-X

7 January 2021

Association of terminal deoxynucleotidyl transferase with Ku

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2800%2900203-X

7 January 2021

Extent to which homology can constrain coding exon junctional diversity in V(D)J recombination

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2800%2900203-X

7 January 2021

The RAG1/RAG2 complex constitutes a 3' flap endonuclease: implications for junctional diversity in V(D)J and transpositional recombination

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2800%2900203-X

7 January 2021

The 3' to 5' exonuclease activity of Mre 11 facilitates repair of DNA double-strand breaks

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2800%2900203-X

7 January 2021

A mechanistic basis for Mre11-directed DNA joining at microhomologies

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2800%2900203-X

7 January 2021

The characterization of a mammalian DNA structure-specific endonuclease

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2800%2900203-X

7 January 2021

A role for FEN-1 in nonhomologous DNA end joining: the order of strand annealing and nucleolytic processing events

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2800%2900203-X

7 January 2021

DNA ligase IV is essential for V(D)J recombination and DNA double-strand break repair in human precursor lymphocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2800%2900203-X

7 January 2021

Ku recruits the XRCC4-ligase IV complex to DNA ends

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2800%2900203-X

7 January 2021

Interactions of the DNA ligase IV-XRCC4 complex with DNA ends and the DNA-dependent protein kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2800%2900203-X

7 January 2021

DNA binding of Xrcc4 protein is associated with V(D)J recombination but not with stimulation of DNA ligase IV activity

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2800%2900203-X

7 January 2021

Lif1p targets the DNA ligase Lig4p to sites of DNA double-strand breaks

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2800%2900203-X

7 January 2021

Ku70-deficient embryonic stem cells have increased ionizing radiosensitivity, defective DNA end-binding activity, and inability to support V(D)J recombination

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2800%2900203-X

7 January 2021

The defect in murine severe combined immune deficiency: joining of signal sequences but not coding segments in V(D)J recombination.

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2800%2900203-X

7 January 2021

Analysis of variable (diversity) joining recombination in DNAdependent protein kinase (DNA-PK)-deficient mice reveals DNA-PK-independent pathways for both signal and coding joint formation

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2800%2900203-X

7 January 2021

Mammalian X-ray-sensitive mutants which are defective in non-homologous (illegitimate) DNA double-strand break repair

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2800%2900203-X

7 January 2021

DNA-PK is essential only for coding joint formation in V(D)J recombination

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2800%2900203-X

7 January 2021

Equine severe combined immunodeficiency: a defect in V(D)J recombination and DNA-dependent protein kinase activity.

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2800%2900203-X

7 January 2021

XR-C1, a new CHO cell mutant which is defective in DNA-PKcs, is impaired in both V(D)J coding and signal joint formation

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2800%2900203-X

7 January 2021

Murine cell line SX9 bearing a mutation in the dna-pkcs gene exhibits aberrant V(D)J recombination not only in the coding joint but also in the signal joint

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2800%2900203-X

7 January 2021

Analyses of TCRB rearrangements substantiate a profound deficit in recombination signal sequence joining in SCID foals: implications for the role of DNA-dependent protein kinase in V(D)J recombination

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2800%2900203-X

7 January 2021

Signal joint formation is also impaired in DNA-dependent protein kinase catalytic subunit knockout cells

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2800%2900203-X

7 January 2021

DNA end-joining catalyzed by human cell-free extracts

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2800%2900203-X

7 January 2021

A new gene involved in DNA double-strand break repair and V(D)J recombination is located on human chromosome 10p

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2800%2900203-X

7 January 2021

10.1016/S0952-7915(00)00203-X

Identifiers

DOI

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6 July 2017

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