(Q78299664)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12354927%20AND%20SRC:MED&resulttype=core&format=json

13 December 2019

review article

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title

Molecular aspects of multiple myeloma (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12354927%20AND%20SRC:MED&resulttype=core&format=json

13 December 2019

1 reference

G Pratt

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12354927%20AND%20SRC:MED&resulttype=core&format=json

13 December 2019

publication date

1 October 2002

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12354927%20AND%20SRC:MED&resulttype=core&format=json

Journal of Clinical Pathology

13 December 2019

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12354927%20AND%20SRC:MED&resulttype=core&format=json

13 December 2019

volume

55

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12354927%20AND%20SRC:MED&resulttype=core&format=json

13 December 2019

issue

5

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12354927%20AND%20SRC:MED&resulttype=core&format=json

13 December 2019

page(s)

273-283

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12354927%20AND%20SRC:MED&resulttype=core&format=json

Expression of the bcl-2 gene in human multiple myeloma cell lines and normal plasma cells

13 December 2019

cites work

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12 December 2020

Poor prognosis in multiple myeloma is associated only with partial or complete deletions of chromosome 13 or abnormalities involving 11q and not with other karyotype abnormalities

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12 December 2020

Karyotype in multiple myeloma and plasma cell leukaemia

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12 December 2020

Concurrent activation of a novel putative transforming gene, myeov, and cyclin D1 in a subset of multiple myeloma cell lines with t(11;14)(q13;q32).

1 reference

12 December 2020

Hypodiploidy is a major prognostic factor in multiple myeloma

1 reference

12 December 2020

Cytogenetic analysis of 280 patients with multiple myeloma and related disorders: primary breakpoints and clinical correlations

1 reference

12 December 2020

p16(INK4a) and p15(INK4b) gene methylations in plasma cells from monoclonal gammopathy of undetermined significance

1 reference

12 December 2020

Unique role of cytogenetics in the prognosis of patients with myeloma receiving high-dose therapy and autotransplants

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12 December 2020

Osteoprotegerin inhibits the development of osteolytic bone disease in multiple myeloma

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12 December 2020

The t(4;14)(p16.3;q32) is strongly associated with chromosome 13 abnormalities in both multiple myeloma and monoclonal gammopathy of undetermined significance

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12 December 2020

Multiple myeloma and the translocation t(11;14)(q13;q32): a report on 13 cases

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12 December 2020

v-maf, a viral oncogene that encodes a "leucine zipper" motif

1 reference

12 December 2020

The retinoblastoma gene (RB-1) status in multiple myeloma: a report on 35 cases.

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12 December 2020

High incidence of chromosome 13 deletion in multiple myeloma detected by multiprobe interphase FISH

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12 December 2020

The interleukin-6 receptor alpha-chain (CD126) is expressed by neoplastic but not normal plasma cells.

1 reference

12 December 2020

Mutational activation of N- and K-ras oncogenes in plasma cell dyscrasias

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12 December 2020

Loss of PTEN expression leading to high Akt activation in human multiple myelomas

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12 December 2020

Monoclonal gammopathy of undetermined significance: chromosome changes are a common finding within bone marrow plasma cells

1 reference

12 December 2020

Bcl-2 protein expression is not related to short survival in multiple myeloma

1 reference

12 December 2020

Prevention of myeloma cell apoptosis by ectopic bcl-2 expression or interleukin 6-mediated up-regulation of bcl-xL

1 reference

12 December 2020

Multiple myeloma: high incidence of chromosomal aneuploidy as detected by interphase fluorescence in situ hybridization

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12 December 2020

Frequent hypermethylation of p16 and p15 genes in multiple myeloma

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12 December 2020

Deregulated FGFR3 mutants in multiple myeloma cell lines with t(4;14): comparative analysis of Y373C, K650E and the novel G384D mutations

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12 December 2020

Frequent translocation t(4;14)(p16.3;q32.3) in multiple myeloma is associated with increased expression and activating mutations of fibroblast growth factor receptor 3

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12 December 2020

Deletion of 13q14 remains an independent adverse prognostic variable in multiple myeloma despite its frequent detection by interphase fluorescence in situ hybridization

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12 December 2020

Cyclin D3 at 6p21 is dysregulated by recurrent chromosomal translocations to immunoglobulin loci in multiple myeloma.

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12 December 2020

Identification of new nonrandom translocations in multiple myeloma with multicolor spectral karyotyping

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12 December 2020

Deregulation of MUM1/IRF4 by chromosomal translocation in multiple myeloma

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12 December 2020

The t(9;14)(p13;q32) chromosomal translocation associated with lymphoplasmacytoid lymphoma involves the PAX-5 gene

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12 December 2020

Interphase fluorescence in situ hybridization (FISH) as a powerful tool for the detection of aneuploidy in multiple myeloma

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12 December 2020

High incidence of translocations t(11;14)(q13;q32) and t(4;14)(p16;q32) in patients with plasma cell malignancies

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12 December 2020

Cellular DNA content as a marker of human multiple myeloma

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12 December 2020

Mutations of the p53 gene in human myeloma cell lines

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12 December 2020

Characterization of nonrandom chromosomal gains and losses in multiple myeloma by comparative genomic hybridization

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12 December 2020

The t(4;14) translocation in myeloma dysregulates both FGFR3 and a novel gene, MMSET, resulting in IgH/MMSET hybrid transcripts

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12 December 2020

Chromosomal analysis in multiple myeloma: cytogenetic evidence of two different diseases

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12 December 2020

Improved cytogenetics in multiple myeloma: a study of 151 patients including 117 patients at diagnosis.

1 reference

12 December 2020

Interleukin-6 promotes multiple myeloma cell growth via phosphorylation of retinoblastoma protein.

1 reference

12 December 2020

The proteasome inhibitor PS-341 inhibits growth, induces apoptosis, and overcomes drug resistance in human multiple myeloma cells.

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12 December 2020

Adhesion to fibronectin via beta1 integrins regulates p27kip1 levels and contributes to cell adhesion mediated drug resistance (CAM-DR).

1 reference

12 December 2020

Analysis of the p16INK4A, p15INK4B and p18INK4C genes in multiple myeloma

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12 December 2020

Multicolour spectral karyotyping identifies new translocations and a recurring pathway for chromosome loss in multiple myeloma

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12 December 2020

Prognostic implications of tumor cell DNA and RNA content in multiple myeloma

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12 December 2020

Hyaluronic acid induces survival and proliferation of human myeloma cells through an interleukin-6-mediated pathway involving the phosphorylation of retinoblastoma protein

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12 December 2020

Global gene expression profiling of multiple myeloma, monoclonal gammopathy of undetermined significance, and normal bone marrow plasma cells

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12 December 2020

Cytogenetic study in multiple myeloma at diagnosis: comparison of two techniques

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12 December 2020

Illegitimate switch recombinations are present in approximately half of primary myeloma tumors, but do not relate to known prognostic indicators or survival

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12 December 2020

Structure-function analysis of the maf oncogene product, a member of the b-Zip protein family.

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12 December 2020

Chromosome translocations in multiple myeloma

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12 December 2020

Insertional events as well as translocations may arise during aberrant immunoglobulin switch recombination in a patient with multiple myeloma.

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12 December 2020

The Ig heavy chain gene is frequently involved in chromosomal translocations in multiple myeloma and plasma cell leukemia as detected by in situ hybridization

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12 December 2020

The role of p53, bcl-2 and bax network in dexamethasone induced apoptosis in multiple myeloma cell lines

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12 December 2020

Chromosomal translocations in lymphoid malignancies reveal novel proto-oncogenes

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12 December 2020

Kaposi's sarcoma-associated herpesvirus infection of bone marrow dendritic cells from multiple myeloma patients

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12 December 2020

Plasma cell karyotype in multiple myeloma.

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12 December 2020

Molecular cytogenetic abnormalities in multiple myeloma and plasma cell leukemia measured using comparative genomic hybridization

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12 December 2020

A variant chromosome translocation at 11q13 identifying PRAD1/cyclin D1 as the BCL-1 gene

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12 December 2020

Myeloma cells induce imbalance in the osteoprotegerin/osteoprotegerin ligand system in the human bone marrow environment

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12 December 2020

Diverse karyotypic abnormalities of the c-myc locus associated with c-myc dysregulation and tumor progression in multiple myeloma

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12 December 2020

The myeloma-associated oncogene fibroblast growth factor receptor 3 is transforming in hematopoietic cells

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12 December 2020

bcl-2 expression in plasma cells from neoplastic gammopathies and reactive plasmacytosis: a comparative study

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12 December 2020

Interphase fluorescence in situ hybridization identifies chromosomal abnormalities in plasma cells from patients with monoclonal gammopathy of undetermined significance

1 reference

12 December 2020

Mechanisms of chromosomal translocations in B cell lymphomas

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12 December 2020

Use of fluorescence in situ hybridization for retrospective detection of aneuploidy in multiple myeloma

1 reference

12 December 2020

Monosomy 13 is associated with the transition of monoclonal gammopathy of undetermined significance to multiple myeloma. Intergroupe Francophone du Myélome.

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12 December 2020

High incidence of deletions but infrequent inactivation of the retinoblastoma gene in human myeloma cells

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12 December 2020

Promiscuous translocations into immunoglobulin heavy chain switch regions in multiple myeloma

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12 December 2020

Melanoma cell expression of Fas(Apo-1/CD95) ligand: implications for tumor immune escape

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12 December 2020

Introduction of an activated N-ras oncogene alters the growth characteristics of the interleukin 6-dependent myeloma cell line ANBL6.

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12 December 2020

Vascular endothelial growth factor triggers signaling cascades mediating multiple myeloma cell growth and migration

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12 December 2020

High levels of soluble syndecan-1 in myeloma-derived bone marrow: modulation of hepatocyte growth factor activity

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12 December 2020

Myeloma and the t(11;14)(q13;q32); evidence for a biologically defined unique subset of patients.

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12 December 2020

Gene rearrangement and overexpression of PRAD1 in lymphoid malignancy with t(11;14)(q13;q32) translocation

1 reference

12 December 2020

Kaposi's sarcoma-associated herpesvirus and multiple myeloma: lack of criteria for causality

1 reference

12 December 2020

Fas-L up-regulation by highly malignant myeloma plasma cells: role in the pathogenesis of anemia and disease progression.

1 reference

12 December 2020

Prognostic value of cytogenetics in multiple myeloma

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12 December 2020

Ectopic expression of fibroblast growth factor receptor 3 promotes myeloma cell proliferation and prevents apoptosis

1 reference

12 December 2020

WWOX, the FRA16D gene, behaves as a suppressor of tumor growth

1 reference

12 December 2020

Activated fibroblast growth factor receptor 3 is an oncogene that contributes to tumor progression in multiple myeloma

1 reference

12 December 2020

Multiple myeloma: almost all patients are cytogenetically abnormal

1 reference

12 December 2020

Detection of t(4;14)(p16.3;q32) chromosomal translocation in multiple myeloma by double-color fluorescent in situ hybridization

1 reference

12 December 2020

p53 and RAS gene mutations in multiple myeloma

1 reference

12 December 2020

The third member of the transforming acidic coiled coil-containing gene family, TACC3, maps in 4p16, close to translocation breakpoints in multiple myeloma, and is upregulated in various cancer cell lines

1 reference

12 December 2020

Analysis of FGFR3 gene mutations in multiple myeloma patients with t(4;14)

1 reference

12 December 2020

High incidence of cryptic translocations involving the Ig heavy chain gene in multiple myeloma, as shown by fluorescence in situ hybridization

1 reference

12 December 2020

Interleukin-6 in human multiple myeloma.

1 reference

12 December 2020

Oncogenesis of multiple myeloma: 14q32 and 13q chromosomal abnormalities are not randomly distributed, but correlate with natural history, immunological features, and clinical presentation

1 reference

12 December 2020

Insertion of excised IgH switch sequences causes overexpression of cyclin D1 in a myeloma tumor cell

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12 December 2020

Dysregulation of cyclin D1 by translocation into an IgH gamma switch region in two multiple myeloma cell lines.

1 reference

12 December 2020

Multiple myeloma: increasing evidence for a multistep transformation process

1 reference

12 December 2020

Hypermethylation of p16INK4A gene promoter during the progression of plasma cell dyscrasia

1 reference

12 December 2020

Interleukin-6 overcomes p21WAF1 upregulation and G1 growth arrest induced by dexamethasone and interferon-gamma in multiple myeloma cells

1 reference

12 December 2020

IRTA1 and IRTA2, novel immunoglobulin superfamily receptors expressed in B cells and involved in chromosome 1q21 abnormalities in B cell malignancy

1 reference

12 December 2020

Presence of a p53 gene deletion in patients with multiple myeloma predicts for short survival after conventional-dose chemotherapy.

1 reference

12 December 2020

WHSC1, a 90 kb SET domain-containing gene, expressed in early development and homologous to a Drosophila dysmorphy gene maps in the Wolf-Hirschhorn syndrome critical region and is fused to IgH in t(4;14) multiple myeloma

1 reference

12 December 2020

Translocations involving the immunoglobulin heavy-chain locus are possible early genetic events in patients with primary systemic amyloidosis

1 reference

12 December 2020

Cytogenetic findings in 200 patients with multiple myeloma

1 reference

12 December 2020

Multicolor spectral karyotyping identifies new recurring breakpoints and translocations in multiple myeloma

1 reference

12 December 2020

Biologic sequelae of nuclear factor-kappaB blockade in multiple myeloma: therapeutic applications

1 reference

12 December 2020

Bone marrow neovascularization, plasma cell angiogenic potential, and matrix metalloproteinase-2 secretion parallel progression of human multiple myeloma

1 reference

12 December 2020

Expanded range of 11q13 breakpoints with differing patterns of cyclin D1 expression in B-cell malignancies.

1 reference

12 December 2020

Novel therapeutic targets in multiple myeloma

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12 December 2020

Improved cytogenetic analysis of bone marrow plasma cells after cytokine stimulation in multiple myeloma: a report on 46 patients.

1 reference

12 December 2020

Detection of t(4;14)(p16.3;q32) chromosomal translocation in multiple myeloma by reverse transcription-polymerase chain reaction analysis of IGH-MMSET fusion transcripts

1 reference

12 December 2020

New insights into role of microenvironment in multiple myeloma

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12 December 2020

Role of CDK4 and p16INK4A in interleukin-6-mediated growth of multiple myeloma

1 reference

12 December 2020

Rearrangements of the c-myc oncogene are present in 15% of primary human multiple myeloma tumors

1 reference

12 December 2020

Chromosome 13 abnormalities identified by FISH analysis and serum beta2-microglobulin produce a powerful myeloma staging system for patients receiving high-dose therapy

1 reference

12 December 2020

p53 gene mutations in multiple myeloma are associated with advanced forms of malignancy

1 reference

12 December 2020

The clinical significance of cytogenetic studies in 100 patients with multiple myeloma, plasma cell leukemia, or amyloidosis

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12 December 2020

Activating mutations of N- and K-ras in multiple myeloma show different clinical associations: analysis of the Eastern Cooperative Oncology Group Phase III Trial

1 reference

12 December 2020

Detection of N-Ras codon 61 mutations in subpopulations of tumor cells in multiple myeloma at presentation

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12 December 2020

Chromosome 11 translocation breakpoints at the PRAD1/cyclin D1 gene locus in centrocytic lymphoma.

1 reference

12 December 2020

Molecular analysis of 11q13 breakpoints in multiple myeloma.

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12 December 2020

Cytogenetics in multiple myeloma: a multicenter study of 24 patients with t(11;14)(q13;q32) or its variant

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12 December 2020

Molecular breakpoints of t(11;14)(q13;q32) in multiple myeloma

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12 December 2020

Identifiers

DOI

10.1136/MP.55.5.273

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12354927%20AND%20SRC:MED&resulttype=core&format=json

13 December 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12354927%20AND%20SRC:MED&resulttype=core&format=json

13 December 2019

PubMed publication ID

12354927

1 reference