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DNA double-strand breaks: signaling, repair and the cancer connection
scientific article (publication date: March 2001)
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Europe PubMed Central
PubMed ID
11242102
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11242102%20AND%20SRC:MED&resulttype=core&format=json
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5 November 2019
review article
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title
DNA double-strand breaks: signaling, repair and the cancer connection
(English)
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Europe PubMed Central
PubMed ID
11242102
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11242102%20AND%20SRC:MED&resulttype=core&format=json
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5 November 2019
author
Stephen P Jackson
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2
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PubMed ID
11242102
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5 November 2019
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Khanna KK
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PubMed ID
11242102
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1 March 2001
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PubMed ID
11242102
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published in
Nature Genetics
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PubMed ID
11242102
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27
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Europe PubMed Central
PubMed ID
11242102
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5 November 2019
page(s)
247-254
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Europe PubMed Central
PubMed ID
11242102
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5 November 2019
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3
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Europe PubMed Central
PubMed ID
11242102
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5 November 2019
cites work
Saccharomyces Ku70, mre11/rad50 and RPA proteins regulate adaptation to G2/M arrest after DNA damage
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F85798
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Defying death after DNA damage.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F85798
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Proximity of chromosomal loci that participate in radiation-induced rearrangements in human cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F85798
retrieved
7 January 2021
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inferred from DOI database lookup
On the role of DNA double-strand breaks in toxicity and carcinogenesis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F85798
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Frequent chromosomal translocations induced by DNA double-strand breaks
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F85798
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Partners and pathwaysrepairing a double-strand break.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F85798
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
DNA double strand break repair in mammalian cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F85798
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Sister chromatid gene conversion is a prominent double-strand break repair pathway in mammalian cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F85798
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Targeted disruption of the Rad51 gene leads to lethality in embryonic mice
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F85798
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Rad51 accumulation at sites of DNA damage and in postreplicative chromatin
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F85798
retrieved
7 January 2021
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inferred from DOI database lookup
XRCC2 and XRCC3, new human Rad51-family members, promote chromosome stability and protect against DNA cross-links and other damages
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F85798
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Disruption of mouse RAD54 reduces ionizing radiation resistance and homologous recombination.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F85798
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mutations of a novel human RAD54 homologue, RAD54B, in primary cancer
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F85798
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mutations in the RAD54 recombination gene in primary cancers
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F85798
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Targeted inactivation of mouse RAD52 reduces homologous recombination but not resistance to ionizing radiation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F85798
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Gatekeepers of recombination
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F85798
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Insights into the functions of BRCA1 and BRCA2.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F85798
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Partial rescue of Brca1 (5-6) early embryonic lethality by p53 or p21 null mutation.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F85798
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F85798
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
BRCA1 is associated with a human SWI/SNF-related complex: linking chromatin remodeling to breast cancer
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F85798
retrieved
7 January 2021
based on heuristic
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Association of BRCA1 with the hRad50-hMre11-p95 complex and the DNA damage response
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F85798
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Frequency of p53 mutations in breast carcinomas from Ashkenazi Jewish carriers of BRCA1 mutations
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F85798
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Conditional mutation of Brca1 in mammary epithelial cells results in blunted ductal morphogenesis and tumour formation.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F85798
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Centrosome amplification and a defective G2-M cell cycle checkpoint induce genetic instability in BRCA1 exon 11 isoform-deficient cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F85798
retrieved
7 January 2021
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Mitotic checkpoint inactivation fosters transformation in cells lacking the breast cancer susceptibility gene, Brca2.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F85798
retrieved
7 January 2021
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Cancer risk and the ATM gene: a continuing debate
1 reference
stated in
Crossref
reference URL
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retrieved
7 January 2021
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inferred from DOI database lookup
Recombinase-activating gene (RAG) 2-mediated V(D)J recombination is not essential for tumorigenesis in Atm-deficient mice
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F85798
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The controlling role of ATM in homologous recombinational repair of DNA damage
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F85798
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
ATM: a mediator of multiple responses to genotoxic stress
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F85798
retrieved
7 January 2021
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inferred from DOI database lookup
Mutant p53 proteins stimulate spontaneous and radiation-induced intrachromosomal homologous recombination independently of the alteration of the transactivation activity and of the G1 checkpoint.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F85798
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Altered telomere nuclear matrix interactions and nucleosomal periodicity in ataxia telangiectasia cells before and after ionizing radiation treatment
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F85798
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Involvement of the TIP60 histone acetylase complex in DNA repair and apoptosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F85798
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
RecQ family helicases: roles in cancer and aging
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F85798
retrieved
7 January 2021
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inferred from DOI database lookup
The DNA-dependent protein kinase
1 reference
stated in
Crossref
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https://api.crossref.org/works/10.1038%2F85798
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7 January 2021
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inferred from DOI database lookup
The Mre11 complex and ATM: collaborating to navigate S phase
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F85798
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The hMre11/hRad50 protein complex and Nijmegen breakage syndrome: linkage of double-strand break repair to the cellular DNA damage response
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F85798
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Nibrin, a novel DNA double-strand break repair protein, is mutated in Nijmegen breakage syndrome
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F85798
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The DNA double-strand break repair gene hMRE11 is mutated in individuals with an ataxia-telangiectasia-like disorder
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F85798
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F85798
retrieved
7 January 2021
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inferred from DOI database lookup
ATM-dependent phosphorylation of nibrin in response to radiation exposure
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F85798
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Functional link between ataxia-telangiectasia and Nijmegen breakage syndrome gene products
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F85798
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
ATM phosphorylation of Nijmegen breakage syndrome protein is required in a DNA damage response
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F85798
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identification of a defect in DNA ligase IV in a radiosensitive leukaemia patient
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F85798
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Interplay of p53 and DNA-repair protein XRCC4 in tumorigenesis, genomic stability and development
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F85798
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
DNA ligase IV deficiency in mice leads to defective neurogenesis and embryonic lethality via the p53 pathway
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F85798
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Defective embryonic neurogenesis in Ku-deficient but not DNA-dependent protein kinase catalytic subunit-deficient mice
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F85798
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Defective neurogenesis resulting from DNA ligase IV deficiency requires Atm
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F85798
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Expression of the ataxia-telangiectasia gene (ATM) product in human cerebellar neurons during development.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F85798
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
DNA repair protein Ku80 suppresses chromosomal aberrations and malignant transformation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F85798
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Genetic pathway to recurrent chromosome translocations in murine lymphoma involves V(D)J recombinase
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F85798
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mutations in the p53 and SCID genes cooperate in tumorigenesis.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F85798
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Splitting the ATM: distinct repair and checkpoint defects in ataxia–telangiectasia
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F85798
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A ribonucleotide reductase gene involved in a p53-dependent cell-cycle checkpoint for DNA damage
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F85798
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
DNA repair protein Rad55 is a terminal substrate of the DNA damage checkpoints
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F85798
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Substrate specificities and identification of putative substrates of ATM kinase family members
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F85798
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Overexpression of a kinase-inactive ATR protein causes sensitivity to DNA-damaging agents and defects in cell cycle checkpoints
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F85798
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A role for ATR in the DNA damage-induced phosphorylation of p53
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F85798
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Targeted disruption of the cell-cycle checkpoint gene ATR leads to early embryonic lethality in mice
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F85798
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Induction of GADD45 and JNK/SAPK-dependent apoptosis following inducible expression of BRCA1.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F85798
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
BRCA1 effects on the cell cycle and the DNA damage response are linked to altered gene expression
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F85798
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Caffeine abolishes the mammalian G(2)/M DNA damage checkpoint by inhibiting ataxia-telangiectasia-mutated kinase activity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F85798
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F85798
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F85798
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Essential role of BETA2/NeuroD1 in development of the vestibular and auditory systems
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F85798
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The G2-phase DNA-damage checkpoint
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F85798
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The G(2) checkpoint is maintained by redundant pathways
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F85798
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Checkpoints: How to activate p53
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F85798
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
DNA damage-induced activation of p53 by the checkpoint kinase Chk2
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F85798
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Heterozygous germ line hCHK2 mutations in Li-Fraumeni syndrome
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F85798
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
hCds1-mediated phosphorylation of BRCA1 regulates the DNA damage response
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F85798
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1038/85798
2 references
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
359712
stated in
Europe PubMed Central
PubMed ID
11242102
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11242102%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 November 2019
OpenCitations bibliographic resource ID
359712
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
359712
PubMed ID
11242102
2 references
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
359712
stated in
Europe PubMed Central
PubMed ID
11242102
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11242102%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 November 2019
ResearchGate publication ID
12090301
0 references
Springer Nature article ID
10.1038/85798
0 references
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