(Q33826737)

29 July 2017

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title

Insights into the functions of BRCA1 and BRCA2. (English)

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29 July 2017

Welcsh PL

1

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29 July 2017

Owens KN

series ordinal

2

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29 July 2017

King MC

series ordinal

3

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29 July 2017

language of work or name

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1 February 2000

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29 July 2017

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29 July 2017

16

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29 July 2017

69-74

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29 July 2017

2

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Linkage of early-onset familial breast cancer to chromosome 17q21

29 July 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2899%2901930-7

7 January 2021

A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2899%2901930-7

7 January 2021

Identification of the breast cancer susceptibility gene BRCA2

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2899%2901930-7

7 January 2021

Allele losses in the region 17q12-21 in familial breast and ovarian cancer involve the wild-type chromosome

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2899%2901930-7

7 January 2021

THE GENETICS OF BREAST CANCER SUSCEPTIBILITY

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2899%2901930-7

7 January 2021

Association of BRCA1 with Rad51 in mitotic and meiotic cells

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2899%2901930-7

7 January 2021

Stable interaction between the products of the BRCA1 and BRCA2 tumor suppressor genes in mitotic and meiotic cells

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2899%2901930-7

7 January 2021

BRCA1 required for transcription-coupled repair of oxidative DNA damage

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2899%2901930-7

7 January 2021

Mitotic checkpoint inactivation fosters transformation in cells lacking the breast cancer susceptibility gene, Brca2.

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2899%2901930-7

7 January 2021

Brca1 deficiency results in early embryonic lethality characterized by neuroepithelial abnormalities

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2899%2901930-7

7 January 2021

The tumor suppressor gene Brca1 is required for embryonic cellular proliferation in the mouse

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2899%2901930-7

7 January 2021

Inactivation of the mouse Brca1 gene leads to failure in the morphogenesis of the egg cylinder in early postimplantation development.

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2899%2901930-7

7 January 2021

Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2899%2901930-7

7 January 2021

Brca2 is required for embryonic cellular proliferation in the mouse

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2899%2901930-7

7 January 2021

Targeted mutations of breast cancer susceptibility gene homologs in mice: lethal phenotypes of Brca1, Brca2, Brca1/Brca2, Brca1/p53, and Brca2/p53 nullizygous embryos

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2899%2901930-7

7 January 2021

Tumorigenesis and a DNA repair defect in mice with a truncating Brca2 mutation

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2899%2901930-7

7 January 2021

Developmental expression of Brca2 colocalizes with Brca1 and is associated with proliferation and differentiation in multiple tissues.

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2899%2901930-7

7 January 2021

RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2899%2901930-7

7 January 2021

BRCA1 is a component of the RNA polymerase II holoenzyme

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2899%2901930-7

7 January 2021

Transcriptional activation by BRCA1

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https://api.crossref.org/works/10.1016%2FS0168-9525%2899%2901930-7

7 January 2021

Evidence for a transcriptional activation function of BRCA1 C-terminal region

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https://api.crossref.org/works/10.1016%2FS0168-9525%2899%2901930-7

7 January 2021

Transcriptional activation functions in BRCA2

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2899%2901930-7

7 January 2021

The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligase

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2899%2901930-7

7 January 2021

Identification of a RING protein that can interact in vivo with the BRCA1 gene product

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2899%2901930-7

7 January 2021

Mapping the functional domains of BRCA1. Interaction of the ring finger domains of BRCA1 and BARD1

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2899%2901930-7

7 January 2021

BAP1: a novel ubiquitin hydrolase which binds to the BRCA1 RING finger and enhances BRCA1-mediated cell growth suppression

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2899%2901930-7

7 January 2021

From BRCA1 to RAP1: a widespread BRCT module closely associated with DNA repair

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2899%2901930-7

7 January 2021

Structure of an XRCC1 BRCT domain: a new protein-protein interaction module

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2899%2901930-7

7 January 2021

RAD51 interacts with the evolutionarily conserved BRC motifs in the human breast cancer susceptibility gene brca2

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2899%2901930-7

7 January 2021

Localization of human BRCA1 and its loss in high-grade, non-inherited breast carcinomas

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2899%2901930-7

7 January 2021

BRCA1 is secreted and exhibits properties of a granin

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2899%2901930-7

7 January 2021

Localization of BRCA1 and a splice variant identifies the nuclear localization signal

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2899%2901930-7

7 January 2021

The nuclear localization sequences of the BRCA1 protein interact with the importin-alpha subunit of the nuclear transport signal receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2899%2901930-7

7 January 2021

Changes in BRCA2 expression during progression of the cell cycle

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2899%2901930-7

7 January 2021

BRCA1 is phosphorylated at serine 1497 in vivo at a cyclin-dependent kinase 2 phosphorylation site

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2899%2901930-7

7 January 2021

BRCA1-associated growth arrest is RB-dependent

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2899%2901930-7

7 January 2021

Centrosome amplification and a defective G2-M cell cycle checkpoint induce genetic instability in BRCA1 exon 11 isoform-deficient cells

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2899%2901930-7

7 January 2021

BRCA1 is associated with the centrosome during mitosis.

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2899%2901930-7

7 January 2021

Mutations of mitotic checkpoint genes in human cancers

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2899%2901930-7

7 January 2021

Brca2 is coordinately regulated with Brca1 during proliferation and differentiation in mammary epithelial cells

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2899%2901930-7

7 January 2021

A mutation in mouse rad51 results in an early embryonic lethal that is suppressed by a mutation in p53

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2899%2901930-7

7 January 2021

Rad51 protein involved in repair and recombination in S. cerevisiae is a RecA-like protein

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2899%2901930-7

7 January 2021

Association of BRCA1 with the hRad50-hMre11-p95 complex and the DNA damage response

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2899%2901930-7

7 January 2021

Dynamic changes of BRCA1 subnuclear location and phosphorylation state are initiated by DNA damage

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2899%2901930-7

7 January 2021

Requirement of ATM-dependent phosphorylation of brca1 in the DNA damage response to double-strand breaks

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2899%2901930-7

7 January 2021

Binding of CtIP to the BRCT repeats of BRCA1 involved in the transcription regulation of p21 is disrupted upon DNA damage

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2899%2901930-7

7 January 2021

Induction of GADD45 and JNK/SAPK-dependent apoptosis following inducible expression of BRCA1.

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2899%2901930-7

7 January 2021

Partial rescue of Brca1 (5-6) early embryonic lethality by p53 or p21 null mutation.

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2899%2901930-7

7 January 2021

Conditional mutation of Brca1 in mammary epithelial cells results in blunted ductal morphogenesis and tumour formation.

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2899%2901930-7

7 January 2021

Increased frequency ofTP53 mutations inBRCA1 andBRCA2 ovarian tumours

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2899%2901930-7

7 January 2021

Novel p53 mutants selected in BRCA-associated tumours which dissociate transformation suppression from other wild-type p53 functions.

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2899%2901930-7

7 January 2021

BRCA1 protein is linked to the RNA polymerase II holoenzyme complex via RNA helicase A

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2899%2901930-7

7 January 2021

Arrest of the cell cycle by the tumour-suppressor BRCA1 requires the CDK-inhibitor p21WAF1/CiP1.

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2899%2901930-7

7 January 2021

BRCA1 regulates p53-dependent gene expression

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2899%2901930-7

7 January 2021

The BRCA2 gene product functionally interacts with p53 and RAD51

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2899%2901930-7

7 January 2021

BRCA1 Inhibition of Estrogen Receptor Signaling in Transfected Cells

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2899%2901930-7

7 January 2021

BRCA1 interacts with components of the histone deacetylase complex

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2899%2901930-7

7 January 2021

BRCA2 associates with acetyltransferase activity when bound to P/CAF

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2899%2901930-7

7 January 2021

Double indemnity: p53, BRCA and cancer. p53 mutation partially rescues developmental arrest in Brca1 and Brca2 null mice, suggesting a role for familial breast cancer genes in DNA damage repair.

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2899%2901930-7

7 January 2021

10.1016/S0168-9525(99)01930-7

Identifiers

DOI

1 reference

29 July 2017

1 reference