(Q52109680)

22 April 2018

title

The RAG-1/2 endonuclease causes genomic instability and controls CNS complications of lymphoblastic leukemia in p53/Prkdc-deficient mice. (English)

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22 April 2018

main subject

lymphoblastic leukemia

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1

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22 April 2018

Jeremy A. Squire

6

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22 April 2018

Jayne S. Danska

9

object named as

Jayne S Danska

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22 April 2018

James Rutka

7

object named as

James T Rutka

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22 April 2018

author name string

Michael D Taylor

2

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22 April 2018

Christine J Williams

3

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22 April 2018

Ildiko Grandal

4

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22 April 2018

Jana Karaskova

5

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22 April 2018

Cynthia J Guidos

8

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22 April 2018

publication date

1 January 2003

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22 April 2018

published in

Cancer Cell

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22 April 2018

volume

3

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22 April 2018

page(s)

37-50

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22 April 2018

issue

1

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22 April 2018

Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice

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7 January 2021

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7 January 2021

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7 January 2021

Mutations in the p53 and SCID genes cooperate in tumorigenesis.

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7 January 2021

Jumping translocations are common in solid tumor cell lines and result in recurrent fusions of whole chromosome arms

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7 January 2021

Gene amplification in a p53-deficient cell line requires cell cycle progression under conditions that generate DNA breakage

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

A central role for chromosome breakage in gene amplification, deletion formation, and amplicon integration

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7 January 2021

Wild-type p53 restores cell cycle control and inhibits gene amplification in cells with mutant p53 alleles.

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7 January 2021

Unrepaired DNA breaks in p53-deficient cells lead to oncogenic gene amplification subsequent to translocations.

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7 January 2021

10.1016/S1535-6108(02)00236-2

Identifiers

DOI

1 reference

22 April 2018

PubMed ID

12559174

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22 April 2018