(Q36376595)

13 August 2017

Evidence for replicative repair of DNA double-strand breaks leading to oncogenic translocation and gene amplification (English)

1 reference

13 August 2017

Michael J Difilippantonio

1

1 reference

13 August 2017

Simone Petersen

2

1 reference

13 August 2017

Hua Tang Chen

3

1 reference

13 August 2017

Roger Johnson

4

1 reference

13 August 2017

Maria Jasin

5

1 reference

13 August 2017

Roland Kanaar

6

1 reference

13 August 2017

Thomas Ried

7

1 reference

13 August 2017

André Nussenzweig

8

1 reference

13 August 2017

language of work or name

English

0 references

publication date

1 August 2002

1 reference

Journal of Experimental Medicine

13 August 2017

1 reference

13 August 2017

196

1 reference

13 August 2017

469-480

1 reference

13 August 2017

4

1 reference

Chromosome organization and genic expression

13 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2196056

The mechanism and regulation of chromosomal V(D)J recombination

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2196056

Targeted transposition by the V(D)J recombinase

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2196056

Impaired nonhomologous end-joining provokes soft tissue sarcomas harboring chromosomal translocations, amplifications, and deletions

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2196056

DNA ligase IV mutations identified in patients exhibiting developmental delay and immunodeficiency

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2196056

Chromosome translocations in multiple myeloma

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2196056

Amplification of oncogenes revisited: from expression profiling to clinical application

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2196056

Genetic requirements for RAD51- and RAD54-independent break-induced replication repair of a chromosomal double-strand break

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2196056

DNA ligase IV deficiency in mice leads to defective neurogenesis and embryonic lethality via the p53 pathway

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2196056

Frequent chromosomal translocations induced by DNA double-strand breaks

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2196056

Recombinase-activating gene (RAG) 2-mediated V(D)J recombination is not essential for tumorigenesis in Atm-deficient mice

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2196056

The nonhomologous end-joining pathway of DNA repair is required for genomic stability and the suppression of translocations

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2196056

Analysis of ku80-mutant mice and cells with deficient levels of p53

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2196056

Interplay of p53 and DNA-repair protein XRCC4 in tumorigenesis, genomic stability and development

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2196056

DNA repair protein Ku80 suppresses chromosomal aberrations and malignant transformation

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2196056

Mouse RAD54 affects DNA double-strand break repair and sister chromatid exchange

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2196056

Identification of a defect in DNA ligase IV in a radiosensitive leukaemia patient

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2196056

Genetic pathway to recurrent chromosome translocations in murine lymphoma involves V(D)J recombinase

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2196056

Double-strand break repair in Ku86- and XRCC4-deficient cells

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2196056

Chromosome break-induced DNA replication leads to nonreciprocal translocations and telomere capture.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2196056

Transposition mediated by RAG1 and RAG2 and its implications for the evolution of the immune system

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2196056

No requirement for V(D)J recombination in p53-deficient thymic lymphoma

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2196056

"Break copy" duplication: a model for chromosome fragment formation in Saccharomyces cerevisiae

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2196056

Ku70 is required for DNA repair but not for T cell antigen receptor gene recombination In vivo

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2196056

Expression of fragile sites triggers intrachromosomal mammalian gene amplification and sets boundaries to early amplicons

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2196056

Chromosomal double-strand break repair in Ku80-deficient cells

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2196056

Atm-deficient mice: a paradigm of ataxia telangiectasia

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2196056

p53 is required for radiation-induced apoptosis in mouse thymocytes

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2196056

Regulation and mechanisms of gene amplification

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2196056

Translocation of the c-myc gene into the immunoglobulin heavy chain locus in human Burkitt lymphoma and murine plasmacytoma cells

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2196056

Stimulation of methotrexate resistance and dihydrofolate reductase gene amplification by c-myc

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2196056

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2196056

Quantitation of immunoglobulin mu-gamma 1 heavy chain switch region recombination by a digestion-circularization polymerase chain reaction method

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2196056

The nonhomologous DNA end joining pathway is important for chromosome stability in primary fibroblasts

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2196056

DNA transposition by the RAG1 and RAG2 proteins: a possible source of oncogenic translocations.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2196056

Interstitial deletions and intrachromosomal amplification initiated from a double-strand break targeted to a mammalian chromosome

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2196056

DNA-PKcs: a T-cell tumour suppressor encoded at the mouse scid locus

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2196056

Growth retardation and leaky SCID phenotype of Ku70-deficient mice.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2196056

Mutations in the p53 and SCID genes cooperate in tumorigenesis.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2196056

Impairment of V(D)J recombination in double-strand break repair mutants

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2196056

Wild-type p53 restores cell cycle control and inhibits gene amplification in cells with mutant p53 alleles.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2196056

V(D)J recombination activates a p53-dependent DNA damage checkpoint in scid lymphocyte precursors.

28 June 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20020851

Disruption of mouse RAD54 reduces ionizing radiation resistance and homologous recombination.

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20020851

A non-transgenic mouse model for B-cell lymphoma: in vivo infection of p53-null bone marrow progenitors by a Myc retrovirus is sufficient for tumorigenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20020851

Genetic interaction between PARP and DNA-PK in V(D)J recombination and tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20020851

Telomere capture stabilizes chromosome breakage

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20020851

Ku86 variant expression and function in multiple myeloma cells is associated with increased sensitivity to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20020851

Regulation of cell survival during B lymphopoiesis: suppressed apoptosis of pro-B cells in P53-deficient mouse bone marrow

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20020851

Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20020851

Abnormal rearrangement within the alpha/delta T-cell receptor locus in lymphomas from Atm-deficient mice

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/12186839

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Rapid allelotype analysis of p53 knockout mice

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/12186839

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1084/JEM.20020851

1 reference

13 August 2017

1 reference

13 August 2017

1 reference