(Q47911157)

6 February 2018

review article

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title

Regulation of immunoglobulin light chain isotype expression (English)

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6 February 2018

author name string

Gorman JR

series ordinal

1

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6 February 2018

Alt FW

series ordinal

2

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6 February 2018

publication date

1 January 1998

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6 February 2018

published in

Advances in Immunology

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6 February 2018

volume

69

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6 February 2018

page(s)

113-181

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6 February 2018

Studies on the properties of P1 site-specific recombination: Evidence for topologically unlinked products following recombination

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Protein tyrosine kinase p56 lck controls allelic exclusion of T-cell receptor β-chain genes

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Re-evaluation of the probabilities for productive rearrangements on the κ andλloci

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Defective T cell receptor signaling and CD8+ thymic selection in humans lacking zap-70 kinase

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The role of the kappa enhancer and its binding factor NF-kappa B in the developmental regulation of kappa gene transcription

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Allelic inclusion in a pre-B-cell line that generates immunoglobulin heavy chain genes in vitro

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Evolution of immunoglobulin V genes: evidence indicating that recently duplicated human V kappa sequences have diverged by gene conversion

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Immunoglobulin lambda gene rearrangement can precede kappa gene rearrangement

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7 January 2021

Content and organization of the human Ig VH locus: definition of three new VH families and linkage to the Ig CH locus

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Sequences of mouse immunoglobulin light chain genes before and after somatic changes

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7 January 2021

Plasmacytomas with more than one immunoglobulin kappa mRNA: implications for allelic exclusion.

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POLYPEPTIDE CHAINS OF HUMAN GAMMA-GLOBULIN: CELLULAR LOCALIZATION BY FLUORESCENT ANTIBODY

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Elements regulating somatic hypermutation of an immunoglobulin κ gene: Critical role for the intron enhancer/matrix attachment region

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Mechanism and developmental program of immunoglobulin gene rearrangement in mammals

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Recombination between immunoglobulin variable region gene segments is enhanced by transcription

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7 January 2021

DNA sequences of the joining regions of mouse lambda light chain immunoglobulin genes

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7 January 2021

Gene-targeted deletion and replacement mutations of the T-cell receptor beta-chain enhancer: the role of enhancer elements in controlling V(D)J recombination accessibility.

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7 January 2021

Composition and function of T-cell receptor and B-cell receptor complexes on precursor lymphocytes

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7 January 2021

Deletion of the mouse T-cell receptor beta gene enhancer blocks alphabeta T-cell development

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7 January 2021

Engagement of the T-cell receptor during positive selection in the thymus down-regulates RAG-1 expression

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7 January 2021

Expression of a microinjected immunoglobulin gene in the spleen of transgenic mice

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7 January 2021

Rearrangement of a chicken immunoglobulin gene occurs in the lymphoid lineage of transgenic mice

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7 January 2021

The role of BSAP (Pax-5) in B-cell development

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7 January 2021

Rabbit lymphoid cells differentiated with respect to alpha-, gamma-, and mu- heavy polypeptide chains and to allotypic markers Aa1 and Aa2

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7 January 2021

Regulation of antigen receptor signal transduction by protein tyrosine kinases

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7 January 2021

ZAP-70 deficiency in an autosomal recessive form of severe combined immunodeficiency

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7 January 2021

The site and stage of anti-DNA B-cell deletion.

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7 January 2021

Gene rearrangement and B-cell development

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7 January 2021

B cell development in mice that lack one or both immunoglobulin kappa light chain genes.

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https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

Immunoglobulin gene rearrangement in B cell deficient mice generated by targeted deletion of the JH locus

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7 January 2021

Mutations of the intronic IgH enhancer and its flanking sequences differentially affect accessibility of the JH locus.

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7 January 2021

An active v-abl protein tyrosine kinase blocks immunoglobulin light-chain gene rearrangement

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7 January 2021

Syk tyrosine kinase required for mouse viability and B-cell development

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7 January 2021

The omega/lambda 5 surrogate immunoglobulin light chain is expressed on the surface of transitional B lymphocytes in murine bone marrow

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7 January 2021

A class switch control region at the 3′ end of the immunoglobulin heavy chain locus

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7 January 2021

The protecton: the unit of humoral immunity selected by evolution

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7 January 2021

Chance, necessity and antibody gene dynamics

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7 January 2021

Aberrant rearrangements contribute significantly to the allelic exclusion of immunoglobulin gene expression

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7 January 2021

V lambda and J lambda-C lambda gene segments of the human immunoglobulin lambda light chain locus are separated by 14 kb and rearrange by a deletion mechanism

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7 January 2021

IGM kappa/lambda EBV human B cell clone: an early step of differentiation of fetal B cells or a distinct B lineage?

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7 January 2021

The mouse IgH 3'-enhancer.

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7 January 2021

A new V gene expressed in lambda-2 light chains of the mouse

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7 January 2021

Transcriptional regulation of multigene loci: multilevel control

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7 January 2021

Expression of lambda and kappa genes can occur in all B cells and is initiated around the same pre-B-cell developmental stage

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7 January 2021

The molecular basis of antibody formation: a paradox

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7 January 2021

Novel kappa light-chain gene rearrangements in mouse lambda light chain-producing B lymphocytes.

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7 January 2021

Parental imprinting of autosomal mammalian genes

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7 January 2021

Epigenetics. A new whiff of monoallelic expression

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7 January 2021

Immunoglobulin heavy and light chain genes rearrange independently at early stages of B cell development

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7 January 2021

Analysis of the B-cell progenitor compartment at the level of single cells.

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7 January 2021

Human severe combined immunodeficiency due to a defect in ZAP-70, a T cell tyrosine kinase

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7 January 2021

A genomic gene encoding the b5 rabbit immunoglobulin kappa constant region: implications for latent allotype phenomenon

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7 January 2021

Differentiation of growth signal requirement of B lymphocyte precursor is directed by expression of immunoglobulin.

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7 January 2021

Combinatorial regulation of transcription. I: General aspects of transcriptional control.

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7 January 2021

Combinatorial regulation of transcription II: The immunoglobulin mu heavy chain gene.

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7 January 2021

Crucial role of the pre-T-cell receptor α gene in development of ap but not γδ T cells

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7 January 2021

Independent rearrangement of Ig lambda genes in tissue culture-derived murine B cell lines

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7 January 2021

Rearrangement of the chicken lambda light chain locus: a silencer/antisilencer regulation

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7 January 2021

Rearrangement-enhancing element upstream of the mouse immunoglobulin kappa chain J cluster.

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7 January 2021

Targeted deletion of 5'HS2 of the murine beta-globin LCR reveals that it is not essential for proper regulation of the beta-globin locus.

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7 January 2021

Transcription of germ line V alpha segments correlates with ongoing T-cell receptor alpha-chain rearrangement

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7 January 2021

Kappa immunoglobulin promoters and enhancers display developmentally controlled interactions

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7 January 2021

Selective synergy of immunoglobulin enhancer elements in B-cell development: a characteristic of kappa light chain enhancers, but not heavy chain enhancers

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7 January 2021

Receptor editing: an approach by autoreactive B cells to escape tolerance

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7 January 2021

Absence of ZAP-70 prevents signaling through the antigen receptor on peripheral blood T cells but not on thymocytes

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7 January 2021

Recent advances in understanding V(D)J recombination.

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7 January 2021

kappa+lambda+ dual receptor B cells are present in the human peripheral repertoire

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7 January 2021

Mice lacking TdT: mature animals with an immature lymphocyte repertoire

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7 January 2021

Human immunoglobulin kappa gene enhancer: chromatin structure analysis at high resolution

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7 January 2021

Ordered rearrangement of variable region genes of the T cell receptor gamma locus correlates with transcription of the unrearranged genes.

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7 January 2021

Regulation of an early developmental checkpoint in the B cell pathway by Ig beta.

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7 January 2021

Rearrangement and expression of rabbit immunoglobulin kappa light chain gene in transgenic mice

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7 January 2021

Immunoglobulin kappa light chain gene promoter and enhancer are not responsible for B-cell restricted gene rearrangement

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7 January 2021

The Ig(kappa) enhancer influences the ratio of Ig(kappa) versus Ig(lambda) B lymphocytes

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7 January 2021

Rearrangement and expression of kappa light chain genes can occur without mu heavy chain expression during differentiation of pre-B cells

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7 January 2021

Down-regulation of RAG1 and RAG2 gene expression in PreB cells after functional immunoglobulin heavy chain rearrangement

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7 January 2021

A novel disulfide-linked heterodimer on pre-T cells consists of the T cell receptor beta chain and a 33 kd glycoprotein

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7 January 2021

B cell development regulated by gene rearrangement: arrest of maturation by membrane-bound D mu protein and selection of DH element reading frames

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7 January 2021

Independent control of immunoglobulin switch recombination at individual switch regions evidenced through Cre-loxP-mediated gene targeting

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7 January 2021

Deletion of a DNA polymerase beta gene segment in T cells using cell type-specific gene targeting

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7 January 2021

Inhibition of immunoglobulin gene rearrangement by the expression of a lambda 2 transgene

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7 January 2021

Neoteny in lymphocytes: Rag1 and Rag2 expression in germinal center B cells

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7 January 2021

Lack of feedback inhibition of V kappa gene rearrangement by productively rearranged alleles

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7 January 2021

Frequent lambda light chain gene rearrangement and expression in a Ly-1 B lymphoma with a productive kappa chain allele

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7 January 2021

Resolution and characterization of pro-B and pre-pro-B cell stages in normal mouse bone marrow

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7 January 2021

Introduction of a subtle mutation into the Hox-2.6 locus in embryonic stem cells

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7 January 2021

The murine kappa light chain shift

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7 January 2021

Depletion of the predominant B-cell population in immunoglobulin mu heavy-chain transgenic mice

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7 January 2021

Cloned human and mouse kappa immunoglobulin constant and J region genes conserve homology in functional segments

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7 January 2021

Human immunoglobulin kappa light-chain genes are deleted or rearranged in lambda-producing B cells

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7 January 2021

Clustered arrangement of immunoglobulin λ constant region genes in man

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https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

Reexpression of RAG-1 and RAG-2 genes in activated mature mouse B cells

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7 January 2021

The 3' enhancer region determines the B/T specificity and pro-B/pre-B specificity of immunoglobulin V kappa-J kappa joining.

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7 January 2021

Evidence for somatic rearrangement of immunoglobulin genes coding for variable and constant regions

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7 January 2021

THE NATURAL-SELECTION THEORY OF ANTIBODY FORMATION

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7 January 2021

Characterization of the human immunoglobulin kappa gene 3' enhancer: functional importance of three motifs that demonstrate B-cell-specific in vivo footprints

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https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

Reading of D genes in variable frames as a source of antibody diversity

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https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

The proteins encoded by the VpreB and lambda 5 pre-B cell-specific genes can associate with each other and with mu heavy chain

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https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

The expression of Vpre-B/lambda 5 surrogate light chain in early bone marrow precursor B cells of normal and B cell-deficient mutant mice

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https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

The coupling between enhancer activity and hypomethylation of kappa immunoglobulin genes is developmentally regulated

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https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

Variant strain of rabbits lacking immunoglobulin κ polypeptide chain

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https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

Expression of the immunoglobulin C mu gene in mouse T and B lymphoid and myeloid cell lines.

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https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

Targeted disruption of mu chain membrane exon causes loss of heavy-chain allelic exclusion

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https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

A B cell-deficient mouse by targeted disruption of the membrane exon of the immunoglobulin mu chain gene

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https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

A critical role of λ5 protein in B cell development

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https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

Allele-specific replication timing of imprinted gene regions

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https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

The human CK gene segment and the kappa deleting element are closely linked

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https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

The v-abl tyrosine kinase negatively regulates NF-kappa B/Rel factors and blocks kappa gene transcription in pre-B lymphocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

Mouse variable-region gene families: complexity, polymorphism and use in non-autoimmune responses

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

Lack of N regions in antigen receptor variable region genes of TdT-deficient lymphocytes

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https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

Mice lacking the c-rel proto-oncogene exhibit defects in lymphocyte proliferation, humoral immunity, and interleukin-2 expression

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https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

Developmental hierarchy of immunoglobulin gene rearrangements in human leukemic pre-B-cells

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https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

Normal human B cells display ordered light chain gene rearrangements and deletions

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https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

Immunoglobulin gene rearrangement and cell surface antigen expression in acute lymphocytic leukemias of T cell and B cell precursor origins.

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7 January 2021

Immunoglobulin isotype expression of normal pre-B cells as determined by immunofluorescence

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https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

Light-chain gene expression before heavy-chain gene rearrangement in pre-B cells transformed by Epstein-Barr virus

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7 January 2021

Characterization of light chain and light chain constant region fragment mRNAs in MPC 11 mouse myeloma cells and variants

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7 January 2021

Organization, structure, and assembly of immunoglobulin heavy chain diversity DNA segments

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https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

Two kappa immunoglobulin genes are expressed in the myeloma S107.

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7 January 2021

Junctional sequences of T cell receptor gamma delta genes: implications for gamma delta T cell lineages and for a novel intermediate of V-(D)-J joining.

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7 January 2021

Targeted oncogene activation by site-specific recombination in transgenic mice

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7 January 2021

Efficient in vivo manipulation of mouse genomic sequences at the zygote stage

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

The E-T (elephant-tadpole) paradox necessitates the concept of a unit of B-cell function: the protection

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

The proportion of B-cell subsets expressing kappa and lambda light chains changes following antigenic selection

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

Expression of surrogate light chain receptors is restricted to a late stage in pre-B cell differentiation

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

A novel germ-line JK transcript starting immediately upstream of JK1

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

Protein-binding sites in Ig gene enhancers determine transcriptional activity and inducibility

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

DNA clones containing mouse immunoglobulin kappa chain genes isolated by in vitro packaging into phage lambda coats

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

C mu-containing transcripts initiate heterogeneously within the IgH enhancer region and contain a novel 5'-nontranslatable exon

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

Functional immunoglobulin light chain genes are replaced by ongoing rearrangements of germline V kappa genes to downstream J kappa segment in a murine B cell line

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

Continuing kappa-gene rearrangement in a cell line transformed by Abelson murine leukemia virus

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

A conserved degradation signal regulates RAG-2 accumulation during cell division and links V(D)J recombination to the cell cycle

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

Tying loose ends: roles of Ku and DNA-dependent protein kinase in the repair of double-strand breaks

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

An enhancer at the 3' end of the mouse immunoglobulin heavy chain locus

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

Immunoglobulin gene transcription ceases upon deletion of a distant enhancer.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

Cell cycle regulation of V(D)J recombination-activating protein RAG-2.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

V(D)J recombination and the cell cycle.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

One heavy chain variable region gene segment subfamily in the BALB/c mouse contains 500-1000 or more members

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

Surrogate Light Chain Expression Is Required to Establish Immunoglobulin Heavy Chain Allelic Exclusion during Early B Cell Development

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

T cell development in mice that lack the zeta chain of the T cell antigen receptor complex

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

An autoimmune reaction against human tissue antigens in certain acute and chronic diseases. II. Clinical correlations

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

An upstream activator of transcription coordinately increases the level and epigenetic stability of gene expression

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

Immunoglobulin gene rearrangement in immature B cells

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

Biased expression of JH-proximal VH genes occurs in the newly generated repertoire of neonatal and adult mice

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

The molecular evolution of the immune response

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

Feedback inhibition of immunoglobulin gene rearrangement by membrane mu, but not by secreted mu heavy chains

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

Induced rearrangement of kappa genes in the BLIN-1 human pre-B cell line correlates with germline J-C kappa and V kappa transcription

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

Identification of a germ line transcript from the unrearranged kappa gene in human B cells

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

Initiation and processing of two kappa immunoglobulin germ line transcripts in mouse B cells

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

Sequences of five potential recombination sites encoded close to an immunoglobulin kappa constant region gene

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

Analysis of junctional diversity during B lymphocyte development

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

Activation of the immunoglobulin kappa 3' enhancer in pre-B cells correlates with the suppression of a nuclear factor binding to a sequence flanking the active core

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

The importance of the 3'-enhancer region in immunoglobulin kappa gene expression

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

Physical linkage of the constant region genes for immunoglobulins lambda I and lambda III

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

Profound block in thymocyte development in mice lacking p56lck

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

Mutations in T-cell antigen receptor genes alpha and beta block thymocyte development at different stages

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

RAG-1-deficient mice have no mature B and T lymphocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

Conservation of the primary structure, organization, and function of the human and mouse beta-globin locus-activating regions

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

Deletions of kappa chain constant region genes in mouse lambda chain-producing B cells involve intrachromosomal DNA recombinations similar to V-J joining

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

Ordered activation of the Ig lambda locus in Abelson B cell lines

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

A physical map and analysis of the murine C kappa-RS region show the presence of a conserved element

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

B cell origin of non-T cell acute lymphoblastic leukemia. A model for discrete stages of neoplastic and normal pre-B cell differentiation

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

Essential role for ZAP-70 in both positive and negative selection of thymocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

Characterization of productive and sterile transcripts from the immunoglobulin heavy-chain locus: processing of micron and muS mRNA.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

Lipopolysaccharide-induced transcription of the kappa immunoglobulin locus occurs on both alleles and is independent of methylatlon status

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

Inducible transcription of the unrearranged kappa constant region locus is a common feature of pre-B cells and does not require DNA or protein synthesis

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

Isotype exclusion and transgene down-regulation in immunoglobulin-λ transgenic mice

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

Normal pre-B cells express a receptor complex of mu heavy chains and surrogate light-chain proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

Cmu gene rearrangement of mouse immunoglobulin genes in normal B cells occurs on both the expressed and nonexpressed chromosomes

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

Allelic exclusion in transgenic mice that express the membrane form of immunoglobulin mu

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

Allelic exclusion in transgenic mice carrying mutant human IgM genes

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

Mechanisms that control antigen receptor variable region gene assembly

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

Signalling in lymphocyte development

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

The K:lambda ratio and B-cell development in the foetal liver

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

Isolation of a candidate repressor/activator, NF-E1 (YY-1, delta), that binds to the immunoglobulin kappa 3' enhancer and the immunoglobulin heavy-chain mu E1 site

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

Chromatin changes accompany immunoglobulin kappa gene activation: a potential control region within the gene

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

The human VH repertoire: a restricted set of VH genes may be the target of immune regulation

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

Unusual patterns of immunoglobulin gene rearrangement and expression during human B cell ontogeny: human B cells can simultaneously express cell surface kappa and lambda light chains

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

A large section of the gene locus encoding human immunoglobulin variable regions of the kappa type is duplicated

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

Cellular localization of immunoglobulins with different allotypic specificities in rabbit lymphoid tissues

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

Transcription of mouse kappa chain genes: implications for allelic exclusion

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

Organization and expression of immunoglobulin genes in fetal liver hybridomas

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

Active lambda and kappa antibody gene rearrangement in Abelson murine leukemia virus-transformed pre-B cell lines

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

A second B cell-specific enhancer 3' of the immunoglobulin heavy-chain locus

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

A lymphocyte-specific enhancer in the mouse immunoglobulin kappa gene.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

Unrearranged immunoglobulin lambda variable region is transcribed in kappa-producing myelomas

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

Formation of disulphide-linked µ2ω2 tetramers in pre-B cells by the 18K ω-immunoglobulin light chain

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

Functional characterization of the developmentally controlled immunoglobulin kappa 3' enhancer: regulation by Id, a repressor of helix-loop-helix transcription factors

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

PU.1 recruits a second nuclear factor to a site important for immunoglobulin kappa 3' enhancer activity

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

Effect of PU.1 phosphorylation on interaction with NF-EM5 and transcriptional activation

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

The hydrolysis of rabbit y-globulin and antibodies with crystalline papain

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

Light chain editing in kappa-deficient animals: a potential mechanism of B cell tolerance

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

Antibody response elicited by T-dependent and T-independent antigens in gene targeted kappa-deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

B lymphocytes may escape tolerance by revising their antigen receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

Clonal selection and learning in the antibody system

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

Mouse kappa light-chain recombination signal sequences mediate recombination more frequently than do those of lambda light chain

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

Restricted association of V and J-C gene segments for mouse lambda chains

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

A novel VH to VHDJH joining mechanism in heavy-chain-negative (null) pre-B cells results in heavy-chain production.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

Novel immunoglobulin heavy chains are produced from DJH gene segment rearrangements in lymphoid cells

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

Regulated progression of a cultured pre-B-cell line to the B-cell stage.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

Induction of light chain expression in a pre-B cell line by fusion to myeloma cells

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

Allelic exclusion and control of endogenous immunoglobulin gene rearrangement in κ transgenic mice

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

Molecular and cellular origins of B lymphocyte diversity

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

Immature surface Ig+ B cells can continue to rearrange kappa and lambda L chain gene loci

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

A developmentally modulated chromatin structure at the mouse immunoglobulin kappa 3' enhancer

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

The primary immunodeficiencies. (2).

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

Transmission and expression of a specific pair of rearranged immunoglobulin μ and κ genes in a transgenic mouse line

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

Analysis and expression of a cloned pre-T cell receptor gene

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

Sequences at the somatic recombination sites of immunoglobulin light-chain genes

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

Identification and nucleotide sequence of a diversity DNA segment (D) of immunoglobulin heavy-chain genes.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

A new variable region in mouse immunoglobulin lambda light chains

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

The V(D)J recombination activating gene, RAG-1.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

Activation of immunoglobulin kappa gene rearrangement correlates with induction of germline kappa gene transcription

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

Heavy-chain directed B-cell maturation: continuous clonal selection beginning at the pre-B cell stage

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

Amplification of immunoglobulin λ constant genes in populations of wild mice

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

The arrangement and rearrangement of antibody genes

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

Immunoglobulin light-chain structural gene sequences cloned in a bacterial plasmid

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

A κ-immunoglobulin gene is formed by site-specific recombination without further somatic mutation

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

Evolution of mouse immunoglobulin lambda genes

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

Multiple nuclear factors interact with the immunoglobulin enhancer sequences

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

Inducibility of kappa immunoglobulin enhancer-binding protein Nf-kappa B by a posttranslational mechanism

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

Targeted disruption of the p50 subunit of NF-kappa B leads to multifocal defects in immune responses

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

In vivo occupancy of the kappa light chain enhancers in primary pro- and pre-B cells: a model for kappa locus activation

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

Stimulation of kappa light-chain gene rearrangement by the immunoglobulin mu heavy chain in a pre-B-cell line

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

Lack of somatic mutation in a kappa light chain transgene.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

Somatic hypermutation of immunoglobulin kappa may depend on sequences 3' of C kappa and occurs on passenger transgenes.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

Restoration of T cell development in RAG-2-deficient mice by functional TCR transgenes.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

Synthesis of immunoglobulin mu chain gene products precedes synthesis of light chains during B-lymphocyte development

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

Immunoglobulin synthesis by lymphoid cells transformed in vitro by Abelson murine leukemia virus

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

A uniform deleting element mediates the loss of kappa genes in human B cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

Accessibility control of antigen-receptor variable-region gene assembly: role of cis-acting elements

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

B cell development under the condition of allelic inclusion.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

Functional immunoglobulin transgenes guide ordered B-cell differentiation in Rag-1-deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

Rearrangement and expression of endogenous immunoglobulin genes occur in many murine B cells expressing transgenic membrane IgM.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

Immunoglobulin gene transcription

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

Molecular defects in a human immunoglobulin kappa chain deficiency.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

VH-gene representation in autoantibodies reflects the normal human B-cell repertoire

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

Transgenic mice with immunoglobulin genes

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

High expression of cloned immunoglobulin kappa gene in transgenic mice is restricted to B lymphocytes.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

Transgenic mice with mu and kappa genes encoding antiphosphorylcholine antibodies

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

Physical linkage of mouse lambda genes by pulsed-field gel electrophoresis suggests that the rearrangement process favors proximate target sequences

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

The immunoglobulin heavy-chain enhancer functions as the promoter for I mu sterile transcription

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

Functional V region formation during in vitro culture of a murine immature B precursor cell line

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

Lambda chain expression at different stages of ontogeny in C57BL/6, BALB/c and SJL mice

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

Variable amplification of immunoglobulin λ light-chain genes in human populations

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

The status of Ig loci rearrangements in single cells from different stages of B cell development

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

Immunoglobulin kappa light chain germ-line transcripts in human precursor B lymphocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

Receptor editing in self-reactive bone marrow B cells

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

Somatic generation of antibody diversity

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

Cloning of an immunoglobulin variable region gene from mouse embryo

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

Sequence of a mouse germ-line gene for a variable region of an immunoglobulin light chain

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

Simian virus 40 enhancer increases number of RNA polymerase II molecules on linked DNA.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

The products of pre-B cell-specific genes (lambda 5 and VpreB) and the immunoglobulin mu chain form a complex that is transported onto the cell surface

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

Cell surface expression of the short immunoglobulin mu chain (D mu protein) in murine pre-B cells is differently regulated from that of the intact mu chain

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

Crosslinking of the cell surface immunoglobulin (mu-surrogate light chains complex) on pre-B cells induces activation of V gene rearrangements at the immunoglobulin kappa locus

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

Human lambda light chain locus: organization and DNA sequences of three genomic J regions

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

In transgenic mice the introduced functional T cell receptor beta gene prevents expression of endogenous beta genes.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

Transcription of the unrearranged mouse Cκ locus: Sequence of the initiation region and comparison of activity with a rearranged Vκ-Cκ gene

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

Structure and expression of the human immunoglobulin lambda genes

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

A theory of allelic and isotypic exclusion for immunoglobulin genes

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

Expression of immunoglobulin heavy chain at a high level in the absence of a proposed immunoglobulin enhancer element in cis

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

Misalignment of V and J gene segments resulting in a nonfunctional immunoglobulin gene

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

Enhancers increase the probability but not the level of gene expression

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

Transcriptional enhancers act in cis to suppress position-effect variegation

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

B lymphocyte-specific protein binding near an immunoglobulin kappa-chain gene J segment

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

A transgenic immunoglobulin mu gene prevents rearrangement of endogenous genes.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

Simian virus 40 enhancer increases RNA polymerase density within the linked gene

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

Megabase inversions in the human genome as physiological events.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

The human immunoglobulin kappa locus consists of two copies that are organized in opposite polarity

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

Multiorgan inflammation and hematopoietic abnormalities in mice with a targeted disruption of RelB, a member of the NF-kappa B/Rel family

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

Formation of stable transcription complexes as assayed by analysis of individual templates

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

Signal transduction by lymphocyte antigen receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

Nucleotide sequence of the intron of the germline human kappa immunoglobulin gene connecting the J and C regions reveals a matrix association region (MAR) next to the enhancer

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

Differentiation of cloned populations of immature B cells after transformation with abelson murine leukemia virus

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

Developmental regulation of V(D)J recombination and lymphocyte differentiation

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

Deletion of the Ig kappa light chain intronic enhancer/matrix attachment region impairs but does not abolish V kappa J kappa rearrangement

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

Function of the pre-T-cell receptor alpha chain in T-cell development and allelic exclusion at the T-cell receptor beta locus

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

Developmentally controlled and tissue-specific expression of unrearranged VH gene segments

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

Regulation of the assembly and expression of variable-region genes

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

Developmentally regulated and strain-specific expression of murine VH gene families

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

Influence of immunoglobulin heavy- and light-chain expression on B-cell differentiation

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

Kappa-chain deficiency. An immunoglobulin disorder

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

Gene targeting in the Ig kappa locus: efficient generation of lambda chain-expressing B cells, independent of gene rearrangements in Ig kappa

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960607-0

7 January 2021

10.1016/S0065-2776(08)60607-0

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6 February 2018