(Q52215914)

27 April 2018

title

Analysis of the B-cell progenitor compartment at the level of single cells. (English)

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27 April 2018

author

Werner Müller

3

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27 April 2018

Klaus Rajewsky

4

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27 April 2018

author name string

Ehlich A

1

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27 April 2018

Martin V

2

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27 April 2018

language of work or name

English

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publication date

1 July 1994

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27 April 2018

published in

Current Biology

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27 April 2018

volume

4

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27 April 2018

issue

7

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27 April 2018

page(s)

573-583

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27 April 2018

Somatic generation of antibody diversity

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Only DFL16, DSP2, and DQ52 gene families exist in mouse immunoglobulin heavy chain diversity gene loci, of which DFL16 and DSP2 originate from the same primordial DH gene

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Novel immunoglobulin heavy chains are produced from DJH gene segment rearrangements in lymphoid cells

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7 January 2021

B cell development regulated by gene rearrangement: arrest of maturation by membrane-bound D mu protein and selection of DH element reading frames

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Allelic exclusion in transgenic mice that express the membrane form of immunoglobulin mu

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Feedback inhibition of immunoglobulin gene rearrangement by membrane mu, but not by secreted mu heavy chains

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7 January 2021

Targeted disruption of mu chain membrane exon causes loss of heavy-chain allelic exclusion

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7 January 2021

Activation of immunoglobulin kappa gene rearrangement correlates with induction of germline kappa gene transcription

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7 January 2021

Light-chain gene expression before heavy-chain gene rearrangement in pre-B cells transformed by Epstein-Barr virus

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Immunoglobulin heavy and light chain genes rearrange independently at early stages of B cell development

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7 January 2021

Immunoglobulin gene rearrangement in B cell deficient mice generated by targeted deletion of the JH locus

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7 January 2021

Rearrangement and expression of kappa light chain genes can occur without mu heavy chain expression during differentiation of pre-B cells

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7 January 2021

Crosslinking of the cell surface immunoglobulin (mu-surrogate light chains complex) on pre-B cells induces activation of V gene rearrangements at the immunoglobulin kappa locus

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7 January 2021

Normal pre-B cells express a receptor complex of mu heavy chains and surrogate light-chain proteins

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7 January 2021

The products of pre-B cell-specific genes (lambda 5 and VpreB) and the immunoglobulin mu chain form a complex that is transported onto the cell surface

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7 January 2021

The proteins encoded by the VpreB and lambda 5 pre-B cell-specific genes can associate with each other and with mu heavy chain

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7 January 2021

A critical role of λ5 protein in B cell development

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7 January 2021

Resolution and characterization of pro-B and pre-pro-B cell stages in normal mouse bone marrow

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7 January 2021

Enumeration and characterization of DJH structures in mouse fetal liver

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7 January 2021

RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement

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7 January 2021

B-lineage cells in mu-transgenic scid mice proliferate in response to IL-7 but fail to show evidence of immunoglobulin light chain gene rearrangement

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7 January 2021

Two murine natural polyreactive autoantibodies are encoded by nonmutated germ-line genes

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7 January 2021

A B cell-deficient mouse by targeted disruption of the membrane exon of the immunoglobulin mu chain gene

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7 January 2021

Regulated progression of a cultured pre-B-cell line to the B-cell stage.

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7 January 2021

Preferential utilization of the most JH-proximal VH gene segments in pre-B-cell lines

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7 January 2021

Biased expression of JH-proximal VH genes occurs in the newly generated repertoire of neonatal and adult mice

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7 January 2021

Most peripheral B cells in mice are ligand selected

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7 January 2021

V region dependent selection of persistent resting peripheral B cells in normal mice

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7 January 2021

Allelic inclusion in a pre-B-cell line that generates immunoglobulin heavy chain genes in vitro

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7 January 2021

A novel VH to VHDJH joining mechanism in heavy-chain-negative (null) pre-B cells results in heavy-chain production.

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7 January 2021

Recombination between an expressed immunoglobulin heavy-chain gene and a germline variable gene segment in a Ly 1+ B-cell lymphoma

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7 January 2021

Proliferation kinetics and the lifespan of B cells in central and peripheral lymphoid organs

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7 January 2021

The regulated expression of B lineage associated genes during B cell differentiation in bone marrow and fetal liver

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7 January 2021

Binding activities of a repertoire of single immunoglobulin variable domains secreted from Escherichia coli

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7 January 2021

Reading of D genes in variable frames as a source of antibody diversity

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7 January 2021

Sequence homologies, N sequence insertion and JH gene utilization in VHDJH joining: implications for the joining mechanism and the ontogenetic timing of Ly1 B cell and B-CLL progenitor generation

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7 January 2021

Lack of N regions in fetal and neonatal mouse immunoglobulin V-D-J junctional sequences

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7 January 2021

Influence of surrogate L chain on DHJH-reading frame 2 suppression in mouse precursor B cells.

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7 January 2021

Cell surface expression of the short immunoglobulin mu chain (D mu protein) in murine pre-B cells is differently regulated from that of the intact mu chain

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7 January 2021

High gradient magnetic cell separation with MACS

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7 January 2021

HPRT-deficient (Lesch-Nyhan) mouse embryos derived from germline colonization by cultured cells

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7 January 2021

Joining of immunoglobulin heavy chain gene segments: implications from a chromosome with evidence of three D-JH fusions

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7 January 2021

Insertion of N regions into heavy-chain genes is correlated with expression of terminal deoxytransferase in B cells

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7 January 2021

Junctional sequences of T cell receptor gamma delta genes: implications for gamma delta T cell lineages and for a novel intermediate of V-(D)-J joining.

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7 January 2021

10.1016/S0960-9822(00)00129-9

Identifiers

DOI

1 reference

27 April 2018

1 reference

27 April 2018