(Q28143901)

English

DNA ligase IV and XRCC4 form a stable mixed tetramer that functions synergistically with other repair factors in a cell-free end-joining system

scientific article (publication date: 3 November 2000)

In more languages

Statements

scholarly article

0 references

DNA ligase IV and XRCC4 form a stable mixed tetramer that functions synergistically with other repair factors in a cell-free end-joining system (English)

0 references

author name string

K J Lee

1

0 references

J Huang

2

0 references

Y Takeda

3

0 references

W S Dynan

4

0 references

language of work or name

0 references

publication date

3 November 2000

0 references

Journal of Biological Chemistry

0 references

275

0 references

34787-96

0 references

44

0 references

Double strand break repair

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M004011200

21 January 2018

DNA double-strand break repair

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M004011200

21 January 2018

Molecular mechanisms of DNA double strand break repair

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M004011200

21 January 2018

The biochemistry and biological significance of nonhomologous DNA end joining: an essential repair process in multicellular eukaryotes

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M004011200

21 January 2018

Double-strand break repair mediated by DNA end-joining.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M004011200

21 January 2018

Ku autoantigen is the regulatory component of a template-associated protein kinase that phosphorylates RNA polymerase II

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M004011200

21 January 2018

The DNA-dependent protein kinase: requirement for DNA ends and association with Ku antigen

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M004011200

21 January 2018

Interaction of DNA-dependent protein kinase with DNA and with Ku: biochemical and atomic-force microscopy studies

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M004011200

21 January 2018

DNA looping by Ku and the DNA-dependent protein kinase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M004011200

21 January 2018

Interaction of Ku protein and DNA-dependent protein kinase catalytic subunit with nucleic acids

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M004011200

21 January 2018

The DNA-dependent protein kinase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M004011200

21 January 2018

Geometry of a complex formed by double strand break repair proteins at a single DNA end: recruitment of DNA-PKcs induces inward translocation of Ku protein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M004011200

21 January 2018

hMre11 and hRad50 nuclear foci are induced during the normal cellular response to DNA double-strand breaks

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M004011200

21 January 2018

The 3' to 5' exonuclease activity of Mre 11 facilitates repair of DNA double-strand breaks

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M004011200

21 January 2018

Nbs1 potentiates ATP-driven DNA unwinding and endonuclease cleavage by the Mre11/Rad50 complex

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M004011200

21 January 2018

Mre11 and Ku70 interact in somatic cells, but are differentially expressed in early meiosis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M004011200

21 January 2018

The Mre11-Rad50-Xrs2 protein complex facilitates homologous recombination-based double-strand break repair in Saccharomyces cerevisiae

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M004011200

21 January 2018

Identification of Saccharomyces cerevisiae DNA ligase IV: involvement in DNA double-strand break repair

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M004011200

21 January 2018

DNA ligase IV is essential for V(D)J recombination and DNA double-strand break repair in human precursor lymphocytes

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M004011200

21 January 2018

Targeted disruption of the gene encoding DNA ligase IV leads to lethality in embryonic mice

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M004011200

21 January 2018

Late embryonic lethality and impaired V(D)J recombination in mice lacking DNA ligase IV

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M004011200

21 January 2018

Joining of nonhomologous DNA double strand breaks in vitro

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M004011200

21 January 2018

DNA end-joining catalyzed by human cell-free extracts

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M004011200

21 January 2018

Ku-dependent nonhomologous DNA end joining in Xenopus egg extracts

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M004011200

21 January 2018

End-joining of free radical-mediated DNA double-strand breaks in vitro is blocked by the kinase inhibitor wortmannin at a step preceding removal of damaged 3' termini

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M004011200

21 January 2018

Molecular cloning and expression of human cDNAs encoding a novel DNA ligase IV and DNA ligase III, an enzyme active in DNA repair and recombination

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M004011200

21 January 2018

DNA ligase IV from HeLa cell nuclei

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M004011200

21 January 2018

Mammalian DNA ligases

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M004011200

21 January 2018

Aberrant DNA repair and DNA replication due to an inherited enzymatic defect in human DNA ligase I

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M004011200

21 January 2018

Involvement of XRCC1 and DNA ligase III gene products in DNA base excision repair.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M004011200

21 January 2018

An interaction between DNA ligase I and proliferating cell nuclear antigen: implications for Okazaki fragment synthesis and joining

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M004011200

21 January 2018

Structure and function of mammalian DNA ligases

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M004011200

21 January 2018

A newly identified DNA ligase of Saccharomyces cerevisiae involved in RAD52-independent repair of DNA double-strand breaks

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M004011200

21 January 2018

Yeast DNA ligase IV mediates non-homologous DNA end joining

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M004011200

21 January 2018

Mammalian DNA double-strand break repair protein XRCC4 interacts with DNA ligase IV

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M004011200

21 January 2018

Activity of DNA ligase IV stimulated by complex formation with XRCC4 protein in mammalian cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M004011200

21 January 2018

Requirement for an interaction of XRCC4 with DNA ligase IV for wild-type V(D)J recombination and DNA double-strand break repair in vivo.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M004011200

21 January 2018

A critical role for DNA end-joining proteins in both lymphogenesis and neurogenesis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M004011200

21 January 2018

Requirement for Ku80 in growth and immunoglobulin V(D)J recombination

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M004011200

21 January 2018

Hypersensitivity of Ku80-deficient cell lines and mice to DNA damage: the effects of ionizing radiation on growth, survival, and development

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M004011200

21 January 2018

Ku70-deficient embryonic stem cells have increased ionizing radiosensitivity, defective DNA end-binding activity, and inability to support V(D)J recombination

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M004011200

21 January 2018

Definition of a core region of RAG-2 that is functional in V(D)J recombination

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M004011200

21 January 2018

Polyacrylamide gel electrophoresis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M004011200

21 January 2018

Size and charge isomer separation and estimation of molecular weights of proteins by disc gel electrophoresis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M004011200

21 January 2018

DNA ligase IV binds to XRCC4 via a motif located between rather than within its BRCT domains

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M004011200

21 January 2018

The XRCC4 gene product is a target for and interacts with the DNA-dependent protein kinase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M004011200

21 January 2018

DNA binding of Xrcc4 protein is associated with V(D)J recombination but not with stimulation of DNA ligase IV activity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M004011200

21 January 2018

Molecular genetic characterization of XRCC4 function

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M004011200

21 January 2018

Ku recruits the XRCC4-ligase IV complex to DNA ends

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M004011200

21 January 2018

Structure of DNA-dependent protein kinase: implications for its regulation by DNA.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M004011200

21 January 2018

Activation of DNA-dependent protein kinase by single-stranded DNA ends

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M004011200

21 January 2018

A RAG1 and RAG2 tetramer complex is active in cleavage in V(D)J recombination

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M004011200

21 January 2018

Identifiers

10.1074/JBC.M004011200

0 references

release_7i5wnfsp2zhetp2u5ihbtrkbmm

1 reference

https://api.fatcat.wiki/v0/release/7i5wnfsp2zhetp2u5ihbtrkbmm

24 November 2022

based on heuristic

mapped directly with Wikidata item

0 references

ResearchGate publication ID

0 references

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q28143901&oldid=1843459596"