Wikidata

(Q21112682)

English

X-ray repair cross complementing 4

mammalian protein found in Homo sapiens

  • DNA repair protein XRCC4
  • X-ray repair complementing defective repair in Chinese hamster cells 4
  • X-ray repair cross-complementing protein 4
  • XRCC4
In more languages

Statements

molecular function
protein binding
determination method
IPI
24 references
retrieved
8 April 2019
stated in
DNA ligase IV is essential for V(D)J recombination and DNA double-strand break repair in human precursor lymphocytes
GOA
curator
UniProt
UniProt protein ID
Q13426
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13426
determination method
IPI
retrieved
8 April 2019
stated in
XLF interacts with the XRCC4-DNA ligase IV complex to promote DNA nonhomologous end-joining
GOA
curator
UniProt
UniProt protein ID
Q13426
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13426
determination method
IPI
retrieved
8 April 2019
stated in
A novel human AP endonuclease with conserved zinc-finger-like motifs involved in DNA strand break responses
GOA
curator
UniProt
UniProt protein ID
Q13426
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13426
determination method
IPI
retrieved
8 April 2019
stated in
APLF (C2orf13) is a novel human protein involved in the cellular response to chromosomal DNA strand breaks
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13426
determination method
IPI
retrieved
8 April 2019
stated in
Dynamic assembly of end-joining complexes requires interaction between Ku70/80 and XRCC4
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13426
determination method
IPI
retrieved
8 April 2019
stated in
A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13426
determination method
IPI
retrieved
8 April 2019
stated in
A human interactome in three quantitative dimensions organized by stoichiometries and abundances
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13426
determination method
IPI
retrieved
8 April 2019
stated in
A proteome-scale map of the human interactome network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13426
determination method
IPI
retrieved
8 April 2019
stated in
Structural Basis of DNA Ligase IV-Artemis Interaction in Nonhomologous End-Joining
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13426
determination method
IPI
retrieved
8 April 2019
stated in
ATM-mediated phosphorylation of polynucleotide kinase/phosphatase is required for effective DNA double-strand break repair
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13426
determination method
IPI
retrieved
8 April 2019
stated in
Identification of VCP/p97, carboxyl terminus of Hsp70-interacting protein (CHIP), and amphiphysin II interaction partners using membrane-based human proteome arrays
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13426
determination method
IPI
retrieved
8 April 2019
stated in
Widespread macromolecular interaction perturbations in human genetic disorders
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13426
determination method
IPI
retrieved
8 April 2019
stated in
APLF promotes the assembly and activity of non-homologous end joining protein complexes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13426
determination method
IPI
retrieved
8 April 2019
stated in
Artemis C-terminal region facilitates V(D)J recombination through its interactions with DNA Ligase IV and DNA-PKcs
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13426
determination method
IPI
retrieved
8 April 2019
stated in
The ataxia-oculomotor apraxia 1 gene product has a role distinct from ATM and interacts with the DNA strand break repair proteins XRCC1 and XRCC4
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13426
determination method
IPI
retrieved
8 April 2019
stated in
XLF interacts with the XRCC4-DNA ligase IV complex to promote DNA nonhomologous end-joining
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13426
determination method
IPI
retrieved
8 April 2019
stated in
Functional significance of the interaction with Ku in DNA double-strand break recognition of XLF
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13426
determination method
IPI
retrieved
8 April 2019
stated in
Crystal structure of an Xrcc4-DNA ligase IV complex
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13426
determination method
IPI
retrieved
8 April 2019
stated in
Structural characterization of filaments formed by human Xrcc4-Cernunnos/XLF complex involved in nonhomologous DNA end-joining
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13426
determination method
IPI
retrieved
8 April 2019
stated in
LuTHy: a double-readout bioluminescence-based two-hybrid technology for quantitative mapping of protein-protein interactions in mammalian cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13426
determination method
IPI
retrieved
8 April 2019
stated in
Ku recruits XLF to DNA double-strand breaks
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13426
determination method
IPI
retrieved
8 April 2019
stated in
A novel human AP endonuclease with conserved zinc-finger-like motifs involved in DNA strand break responses
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13426
determination method
IPI
retrieved
8 April 2019
stated in
Conserved interactions of the splicing factor Ntr1/Spp382 with proteins involved in DNA double-strand break repair and telomere metabolism
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13426
determination method
IPI
retrieved
8 April 2019
stated in
TRF2 interaction with Ku heterotetramerization interface gives insight into c-NHEJ prevention at human telomeres
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13426
determination method
IPI
cell component
nucleus
determination method
NAS
IDA
IEA
6 references
retrieved
27 February 2018
stated in
XLF interacts with the XRCC4-DNA ligase IV complex to promote DNA nonhomologous end-joining
GOA
curator
UniProt
UniProt protein ID
Q13426
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13426&geneProductId=UniProtKB:Q13426
determination method
NAS
retrieved
27 February 2018
stated in
GOA
curator
UniProt
UniProt protein ID
Q13426
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13426&geneProductId=UniProtKB:Q13426
determination method
IEA
retrieved
27 February 2018
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13426&geneProductId=UniProtKB:Q13426
determination method
IEA
retrieved
27 February 2018
stated in
Mammalian DNA double-strand break repair protein XRCC4 interacts with DNA ligase IV
GOA
curator
UniProt
UniProt protein ID
Q13426
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13426&geneProductId=UniProtKB:Q13426
determination method
IDA
retrieved
27 February 2018
stated in
In vitro and in vivo interactions of DNA ligase IV with a subunit of the condensin complex
GOA
curator
UniProt
UniProt protein ID
Q13426
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13426&geneProductId=UniProtKB:Q13426
determination method
IDA
retrieved
27 February 2018
stated in
GOA
curator
Human Protein Atlas
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13426&geneProductId=UniProtKB:Q13426
determination method
IDA
nucleus
determination method
IBA
IDA
IEA
NAS
7 references
retrieved
8 April 2019
stated in
XLF interacts with the XRCC4-DNA ligase IV complex to promote DNA nonhomologous end-joining
GOA
curator
UniProt
UniProt protein ID
Q13426
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13426
determination method
NAS
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q13426
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13426
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13426
determination method
IEA
retrieved
8 April 2019
stated in
Mammalian DNA double-strand break repair protein XRCC4 interacts with DNA ligase IV
GOA
curator
UniProt
UniProt protein ID
Q13426
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13426
determination method
IDA
retrieved
8 April 2019
stated in
In vitro and in vivo interactions of DNA ligase IV with a subunit of the condensin complex
GOA
curator
UniProt
UniProt protein ID
Q13426
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13426
determination method
IDA
retrieved
8 April 2019
stated in
GOA
curator
Human Protein Atlas
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13426
determination method
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13426
determination method
IBA
biological process

Identifiers

PDB structure ID
 
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