(Q2034004)

http://www.ebi.ac.uk/interpro/protein/P14416

G protein-coupled receptor

1 reference

Transporter Classification Database ID

9.A.14.3.10

hierarchical database ID heuristic

2 October 2019

based on heuristic

GPCR, rhodopsin-like, 7TM, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

protein homodimerization activity

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14416

potassium channel regulator activity

1 reference

21 June 2018

G protein-coupled receptors form stable complexes with inwardly rectifying potassium channels and adenylyl cyclase

http://www.ebi.ac.uk/QuickGO/annotations?protein=P14416&geneProductId=UniProtKB:P14416

identical protein binding

NAS

1 reference

1 January 2018

Dopamine D2 receptors form higher order oligomers at physiological expression levels

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14416

G protein-coupled receptor activity

IPI

3 references

1 January 2018

Interactions between calmodulin, adenosine A2A, and dopamine D2 receptors

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14416

1 January 2018

Dopamine transporter cell surface localization facilitated by a direct interaction with the dopamine D2 receptor

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14416

1 January 2018

Modulation of dopamine D(2) receptor signaling by actin-binding protein (ABP-280)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14416

signal transducer activity

IPI

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P14416&geneProductId=UniProtKB:P14416

adrenergic receptor activity

1 reference

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14416

signaling receptor binding

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14416

ionotropic glutamate receptor binding

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14416

protein heterodimerization activity

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14416

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14416

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14416

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14416

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14416

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14416

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14416

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14416

4 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14416

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14416

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14416

1 January 2018

The protein arginine methyltransferase PRMT5 promotes D2-like dopamine receptor signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14416

1 reference

1 January 2018

DISC1 regulates primary cilia that display specific dopamine receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14416

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14416

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14416

lateral plasma membrane

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14416

intracellular anatomical structure

1 reference

21 June 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P14416&geneProductId=UniProtKB:P14416

1 reference

1 January 2018

DISC1 regulates primary cilia that display specific dopamine receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14416

integral component of plasma membrane

1 reference

16 July 2018

Dopamine D4 receptors elevated in schizophrenia

http://www.ebi.ac.uk/QuickGO/annotations?protein=P14416&geneProductId=UniProtKB:P14416

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14416

glutamatergic synapse

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14416

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14416

integral component of postsynaptic membrane

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14416

integral component of presynaptic membrane

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14416

synaptic vesicle membrane

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14416

adenylate cyclase-inhibiting dopamine receptor signaling pathway

biological process

4 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14416

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14416

1 January 2018

The protein arginine methyltransferase PRMT5 promotes D2-like dopamine receptor signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14416

1 January 2018

Chimeric D2/D3 dopamine receptors efficiently inhibit adenylyl cyclase in HEK 293 cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14416

positive regulation of urine volume

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14416

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14416

response to inactivity

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14416

modulation of chemical synaptic transmission

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14416

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14416

negative regulation of protein kinase B signaling

3 references

1 January 2018

A role for Akt and glycogen synthase kinase-3 as integrators of dopamine and serotonin neurotransmission in mental health

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14416

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14416

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14416

positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway

1 reference

21 June 2018

Differential sensitivity of the short and long human dopamine D2 receptor subtypes to protein kinase C

http://www.ebi.ac.uk/QuickGO/annotations?protein=P14416&geneProductId=UniProtKB:P14416

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14416

Wnt signaling pathway

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14416

negative regulation of innate immune response

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14416

regulation of phosphoprotein phosphatase activity

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14416

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14416

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14416

positive regulation of G protein-coupled receptor signaling pathway

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14416

response to axon injury

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14416

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14416

activation of protein kinase activity

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14416

forebrain development

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14416

orbitofrontal cortex development

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14416

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14416

positive regulation of ERK1 and ERK2 cascade

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14416

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14416

positive regulation of renal sodium excretion

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14416

negative regulation of insulin secretion

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14416

intracellular signal transduction

1 reference

21 June 2018

Differential sensitivity of the short and long human dopamine D2 receptor subtypes to protein kinase C

http://www.ebi.ac.uk/QuickGO/annotations?protein=P14416&geneProductId=UniProtKB:P14416

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14416

behavioral response to ethanol

adenylate cyclase-activating adrenergic receptor signaling pathway

1 reference

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14416

positive regulation of cytokinesis

1 reference

1 January 2018

G protein-coupled receptors participate in cytokinesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14416

regulation of potassium ion transport

IMP

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14416

cellular calcium ion homeostasis

1 reference

21 June 2018

Pharmacology of high-threshold calcium currents in GH4C1 pituitary cells and their regulation by activation of human D2 and D4 dopamine receptors

http://www.ebi.ac.uk/QuickGO/annotations?protein=P14416&geneProductId=UniProtKB:P14416

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14416

regulation of MAPK cascade

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14416

Dopamine modulates von Willebrand factor secretion in endothelial cells via D2-D4 receptors

response to histamine

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14416

negative regulation of synaptic transmission, glutamatergic

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14416

negative regulation of circadian sleep/wake cycle, sleep

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14416

negative regulation of protein secretion

1 reference

1 January 2018

Dopamine modulates von Willebrand factor secretion in endothelial cells via D2-D4 receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14416

regulation of locomotion involved in locomotory behavior

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14416

dopamine receptor signaling pathway

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14416

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14416

positive regulation of receptor internalization

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14416

arachidonic acid secretion

1 reference

1 January 2018

Expression and pharmacological characterization of the human D3 dopamine receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14416

positive regulation of transcription by RNA polymerase II

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14416

G protein-coupled receptor internalization

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14416

positive regulation of multicellular organism growth

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14416

positive regulation of long-term synaptic potentiation

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14416

negative regulation of dopamine secretion

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14416

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14416

regulation of synapse structural plasticity

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14416

adenylate cyclase-modulating G protein-coupled receptor signaling pathway

1 reference

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P14416&geneProductId=UniProtKB:P14416

behavioral response to cocaine

release of sequestered calcium ion into cytosol

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14416

negative regulation of voltage-gated calcium channel activity

ISS

3 references

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P14416&geneProductId=UniProtKB:P14416

21 June 2018

Pharmacology of high-threshold calcium currents in GH4C1 pituitary cells and their regulation by activation of human D2 and D4 dopamine receptors

http://www.ebi.ac.uk/QuickGO/annotations?protein=P14416&geneProductId=UniProtKB:P14416

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P14416&geneProductId=UniProtKB:P14416

G protein-coupled receptor signaling pathway

4 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14416

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14416

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14416

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14416

excitatory postsynaptic potential

1 reference

1 January 2018

A role for Akt and glycogen synthase kinase-3 as integrators of dopamine and serotonin neurotransmission in mental health

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14416

negative regulation of protein phosphorylation

NAS

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14416

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14416

positive regulation of neurogenesis

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14416

negative regulation of cell death

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14416

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14416

adrenergic receptor signaling pathway

1 reference

16 July 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P14416&geneProductId=UniProtKB:P14416

negative regulation of adenylate cyclase activity

1 reference

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P14416&geneProductId=UniProtKB:P14416

regulation of neurotransmitter uptake

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14416

postsynaptic modulation of chemical synaptic transmission

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14416

regulation of synaptic vesicle exocytosis

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14416

synaptic transmission, dopaminergic

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14416

response to toxic substance

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14416

negative regulation of cytosolic calcium ion concentration

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14416

negative regulation of voltage-gated calcium channel activity

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14416

physically interacts with

1 reference

7124

17 August 2016

1 reference

8434

17 August 2016

1 reference

8436

17 August 2016

1 reference

8435

17 August 2016

1 reference

7295

17 August 2016

1 reference

941

17 August 2016

1 reference

7427

English

7-hydroxy-2-(di-N-propylamino)tetralin

17 August 2016

has use

agonist

1 reference

950

17 August 2016

1 reference

35

17 August 2016

1 reference

940

17 August 2016

1 reference

48

17 August 2016

1 reference

953

17 August 2016

1 reference

954

17 August 2016

1 reference

2

17 August 2016

1 reference

3949

17 August 2016

1 reference

33

17 August 2016

1 reference

34

17 August 2016

1 reference

7672

17 August 2016

1 reference

37

17 August 2016

1 reference

43

17 August 2016

1 reference

49

17 August 2016

1 reference

52

17 August 2016

1 reference

56

17 August 2016

1 reference

963

17 August 2016

1 reference

7670

17 August 2016

1 reference

62

17 August 2016

1 reference

83

17 August 2016

1 reference

38

17 August 2016

1 reference

965

17 August 2016

1 reference

966

17 August 2016

1 reference

948

17 August 2016

1 reference

204

17 August 2016

1 reference

86

17 August 2016

1 reference

177

17 August 2016

1 reference

205

17 August 2016

1 reference

7227

17 August 2016

1 reference

44

17 August 2016

1 reference

47

17 August 2016

1 reference

7556

17 August 2016

1 reference

209

17 August 2016

1 reference

90

17 August 2016

1 reference

7557

17 August 2016

1 reference

7279

17 August 2016

1 reference

7281

17 August 2016

1 reference

50

17 August 2016

1 reference

94

17 August 2016

1 reference

96

17 August 2016

1 reference

98

17 August 2016

1 reference

5501

17 August 2016

1 reference

958

17 August 2016

1 reference

214

17 August 2016

1 reference

59

17 August 2016

1 reference

103

English

GPCR, rhodopsin-like, 7TM

17 August 2016

Gene Atlas image

PBB GE DRD2 216924 s at fs.png
732 × 530; 12 KB

0 references

has part(s)

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P14416

Identifiers

MeSH descriptor ID

C581293

subject named as

DRD2 protein, human

0 references

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

28 October 2013

1 reference

8 August 2019

Transporter Classification Database ID

English

9.A.14.3.10

2 references

Transporter Classification database

13 March 2020

Transporter Classification database

29 April 2020

1 reference

inferred by common MeSH mappings on source and on Wikidata

UMLS 2023