(Q2042529)

English

Toll like receptor 9

mammalian protein found in Homo sapiens

uniprot:Q9NR96
toll-like receptor 9
TLR9

In more languages

Statements

1 reference

13 November 2019

UniProt protein ID

toll-like receptor

0 references

Toll/interleukin-1 receptor homology (TIR) domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9NR96

toll-like receptor 9

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9NR96

Toll/interleukin-1 receptor homology (TIR) domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Leucine-rich repeat, typical subtype, protein family

1 reference

based on heuristic

inferred from protein domain or family

Leucine-rich repeat, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

determination method

1 reference

8 April 2019

Sequence-specific potent induction of IFN-alpha by short interfering RNA in plasmacytoid dendritic cells through TLR7

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NR96

determination method

interleukin-1 receptor binding

determination method

1 reference

8 April 2019

SIGIRR, a negative regulator of Toll-like receptor-interleukin 1 receptor signaling

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NR96

determination method

transmembrane signaling receptor activity

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NR96

determination method

1-phosphatidylinositol-3-kinase activity

determination method

1 reference

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NR96&geneProductId=UniProtKB:Q9NR96

determination method

protein homodimerization activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NR96

determination method

unmethylated CpG binding

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NR96

determination method

pattern recognition receptor activity

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NR96

determination method

determination method

1 reference

8 April 2019

Cultured human melanocytes express functional toll-like receptors 2-4, 7 and 9

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NR96

determination method

determination method

2 references

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NR96

determination method

early phagosome

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NR96

determination method

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NR96

determination method

plasma membrane

determination method

1 reference

24 April 2018

Cultured human melanocytes express functional toll-like receptors 2-4, 7 and 9

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NR96&geneProductId=UniProtKB:Q9NR96

determination method

extracellular region

determination method

1 reference

8 April 2019

A Toll-like receptor recognizes bacterial DNA

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NR96

determination method

basolateral plasma membrane

determination method

1 reference

8 April 2019

Maintenance of colonic homeostasis by distinctive apical TLR9 signalling in intestinal epithelial cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NR96

determination method

apical plasma membrane

determination method

1 reference

8 April 2019

Maintenance of colonic homeostasis by distinctive apical TLR9 signalling in intestinal epithelial cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NR96

determination method

phagocytic vesicle

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NR96

determination method

endolysosome membrane

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NR96

determination method

determination method

2 references

endosome membrane

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NR96

determination method

cytoplasmic vesicle

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NR96

determination method

extracellular space

determination method

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NR96&geneProductId=UniProtKB:Q9NR96

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NR96

determination method

biological process

positive regulation of interleukin-18 production

determination method

1 reference

8 April 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NR96

determination method

positive regulation of toll-like receptor signaling pathway

determination method

1 reference

8 April 2019

Maintenance of colonic homeostasis by distinctive apical TLR9 signalling in intestinal epithelial cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NR96

determination method

positive regulation of interleukin-12 production

determination method

1 reference

8 April 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NR96

determination method

determination method

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NR96&geneProductId=UniProtKB:Q9NR96

determination method

positive regulation of interleukin-10 production

determination method

1 reference

8 April 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NR96

determination method

immune system process

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NR96

determination method

positive regulation of JUN kinase activity

determination method

1 reference

8 April 2019

Maintenance of colonic homeostasis by distinctive apical TLR9 signalling in intestinal epithelial cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NR96

determination method

negative regulation of interleukin-6 production

determination method

1 reference

8 April 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NR96

determination method

I-kappaB phosphorylation

determination method

1 reference

8 April 2019

Cultured human melanocytes express functional toll-like receptors 2-4, 7 and 9

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NR96

determination method

positive regulation of JNK cascade

determination method

1 reference

8 April 2019

Maintenance of colonic homeostasis by distinctive apical TLR9 signalling in intestinal epithelial cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NR96

determination method

positive regulation of nitric-oxide synthase biosynthetic process

determination method

1 reference

8 April 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NR96

determination method

MyD88-dependent toll-like receptor signaling pathway

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NR96

determination method

negative regulation of interleukin-8 production

determination method

1 reference

8 April 2019

Maintenance of colonic homeostasis by distinctive apical TLR9 signalling in intestinal epithelial cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NR96

determination method

positive regulation of gene expression

determination method

1 reference

8 April 2019

TLR9 and RIG-I signaling in human endocervical epithelial cells modulates inflammatory responses of macrophages and dendritic cells in vitro

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NR96

determination method

negative regulation of ATPase-coupled calcium transmembrane transporter activity

determination method

1 reference

8 April 2019

Toll-like receptor 9 protects non-immune cells from stress by modulating mitochondrial ATP synthesis through the inhibition of SERCA2

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NR96

determination method

negative regulation of toll-like receptor signaling pathway

determination method

1 reference

8 April 2019

Maintenance of colonic homeostasis by distinctive apical TLR9 signalling in intestinal epithelial cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NR96

determination method

defense response to bacterium

determination method

1 reference

8 April 2019

A Toll-like receptor recognizes bacterial DNA

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NR96

determination method

maintenance of gastrointestinal epithelium

determination method

1 reference

8 April 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NR96

determination method

positive regulation of granulocyte macrophage colony-stimulating factor production

determination method

1 reference

8 April 2019

TLR9 and RIG-I signaling in human endocervical epithelial cells modulates inflammatory responses of macrophages and dendritic cells in vitro

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NR96

determination method

positive regulation of NF-kappaB transcription factor activity

determination method

1 reference

24 April 2018

Maintenance of colonic homeostasis by distinctive apical TLR9 signalling in intestinal epithelial cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NR96&geneProductId=UniProtKB:Q9NR96

determination method

positive regulation of interleukin-8 production

determination method

3 references

8 April 2019

TLR9 and RIG-I signaling in human endocervical epithelial cells modulates inflammatory responses of macrophages and dendritic cells in vitro

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NR96

determination method

8 April 2019

Maintenance of colonic homeostasis by distinctive apical TLR9 signalling in intestinal epithelial cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NR96

determination method

8 April 2019

Cultured human melanocytes express functional toll-like receptors 2-4, 7 and 9

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NR96

determination method

positive regulation of interleukin-6 production

determination method

2 references

positive regulation of tumor necrosis factor production

determination method

1 reference

8 April 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NR96

determination method

positive regulation of I-kappaB kinase/NF-kappaB signaling

determination method

1 reference

8 April 2019

Maintenance of colonic homeostasis by distinctive apical TLR9 signalling in intestinal epithelial cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NR96

determination method

positive regulation of chemokine production

determination method

1 reference

8 April 2019

Cultured human melanocytes express functional toll-like receptors 2-4, 7 and 9

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NR96

determination method

tumor necrosis factor production

determination method

1 reference

24 April 2018

TLR7/TLR8 Activation Restores Defective Cytokine Secretion by Myeloid Dendritic Cells but Not by Plasmacytoid Dendritic Cells in HIV-Infected Pregnant Women and Newborns

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NR96&geneProductId=UniProtKB:Q9NR96

determination method

innate immune response

determination method

3 references

inflammatory response

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NR96

determination method

negative regulation of NF-kappaB transcription factor activity

determination method

1 reference

8 April 2019

Maintenance of colonic homeostasis by distinctive apical TLR9 signalling in intestinal epithelial cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NR96

determination method

positive regulation of transcription by RNA polymerase II

determination method

1 reference

8 April 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NR96

determination method

signal transduction

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NR96

determination method

positive regulation of interferon-beta production

determination method

1 reference

8 April 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NR96

determination method

toll-like receptor signaling pathway

determination method

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NR96&geneProductId=UniProtKB:Q9NR96

determination method

phosphatidylinositol-3-phosphate biosynthetic process

determination method

1 reference

10 September 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NR96&geneProductId=UniProtKB:Q9NR96

determination method

positive regulation of immunoglobulin production

determination method

1 reference

8 April 2019

FCRL3 promotes TLR9-induced B-cell activation and suppresses plasma cell differentiation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NR96

determination method

positive regulation of B cell proliferation

determination method

1 reference

8 April 2019

FCRL3 promotes TLR9-induced B-cell activation and suppresses plasma cell differentiation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NR96

determination method

regulation of toll-like receptor 9 signaling pathway

determination method

1 reference

8 April 2019

FCRL3 promotes TLR9-induced B-cell activation and suppresses plasma cell differentiation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NR96

determination method

positive regulation of MAPK cascade

determination method

1 reference

8 April 2019

FCRL3 promotes TLR9-induced B-cell activation and suppresses plasma cell differentiation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NR96

determination method

regulation of B cell differentiation

determination method

1 reference

8 April 2019

FCRL3 promotes TLR9-induced B-cell activation and suppresses plasma cell differentiation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NR96

determination method

positive regulation of B cell activation

determination method

1 reference

8 April 2019

FCRL3 promotes TLR9-induced B-cell activation and suppresses plasma cell differentiation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NR96

determination method

positive regulation of NIK/NF-kappaB signaling

determination method

1 reference

8 April 2019

Cultured human melanocytes express functional toll-like receptors 2-4, 7 and 9

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NR96

determination method

immune response

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NR96

determination method

I-kappaB kinase/NF-kappaB signaling

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NR96

determination method

tumor necrosis factor production

determination method

positive regulation of interleukin-6 production

determination method

3 references

8 April 2019

TLR9 and RIG-I signaling in human endocervical epithelial cells modulates inflammatory responses of macrophages and dendritic cells in vitro

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NR96

determination method

8 April 2019

Cultured human melanocytes express functional toll-like receptors 2-4, 7 and 9

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NR96

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NR96

determination method

defense response to virus

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NR96

determination method

physically interacts with

hydroxychloroquine

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

language of work or name

17 August 2016

agatolimod sodium

object has role

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL2103793

leucine-rich repeat, typical subtype

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9NR96

Toll/interleukin-1 receptor homology (TIR) domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9NR96

Leucine-rich repeat

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9NR96

Identifiers

RefSeq protein ID

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000353874

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000353874

1 reference

Freebase Data Dumps

publication date

28 October 2013

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q2042529&oldid=2139454400"