(Q21100975)

Immunoglobulin-like fold

1 reference

Protein kinase-like domain superfamily

1 reference

Immunoglobulin-like domain superfamily

1 reference

Serine-threonine/tyrosine-protein kinase, catalytic domain, protein family

1 reference

Immunoglobulin subtype, protein family

1 reference

Immunoglobulin subtype 2, protein family

1 reference

Protein kinase domain, protein family

1 reference

immunoglobulin-like domain, protein family

1 reference

Protein kinase, ATP binding site, protein family

1 reference

Tyrosine-protein kinase, catalytic domain, protein family

1 reference

Tyrosine-protein kinase, receptor class III, conserved site, protein family

1 reference

Tyrosine-protein kinase, active site, protein family

1 reference

Immunoglobulin domain, protein family

1 reference

1 reference

13 November 2019

1 reference

13 November 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07333

1 reference

9 May 2019

protein kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07333

1 reference

9 May 2019

transferase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07333

1 reference

9 May 2019

transmembrane receptor protein tyrosine kinase activity

kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07333

1 reference

9 May 2019

protein phosphatase binding

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07333

macrophage colony-stimulating factor receptor activity

5 references

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07333&geneProductId=UniProtKB:P07333

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07333&geneProductId=UniProtKB:P07333

10 September 2018

Expression of human colony-stimulating factor-1 (CSF-1) receptor in murine pluripotent hematopoietic NFS-60 cells induces long-term proliferation in response to CSF-1 without loss of erythroid differentiation potential

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07333&geneProductId=UniProtKB:P07333

10 September 2018

Functional overlap but differential expression of CSF-1 and IL-34 in their CSF-1 receptor-mediated regulation of myeloid cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07333&geneProductId=UniProtKB:P07333

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07333&geneProductId=UniProtKB:P07333

cytokine binding

Structure of macrophage colony stimulating factor bound to FMS: diverse signaling assemblies of class III receptor tyrosine kinases

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07333

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07333

9 May 2019

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07333

9 May 2019

Functional overlap but differential expression of CSF-1 and IL-34 in their CSF-1 receptor-mediated regulation of myeloid cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07333

protein binding

5 references

9 May 2019

Structure and Assembly Mechanism of the Signaling Complex Mediated by Human CSF-1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07333

9 May 2019

Allosteric competitive inactivation of hematopoietic CSF-1 signaling by the viral decoy receptor BARF1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07333

9 May 2019

Extracellular complexes of the hematopoietic human and mouse CSF-1 receptor are driven by common assembly principles

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07333

9 May 2019

Structural basis for the dual recognition of helical cytokines IL-34 and CSF-1 by CSF-1R

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07333

9 May 2019

Human IL-34 and CSF-1 establish structurally similar extracellular assemblies with their common hematopoietic receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07333

receptor tyrosine kinase

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07333&geneProductId=UniProtKB:P07333

4 references

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07333&geneProductId=UniProtKB:P07333

10 September 2018

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07333&geneProductId=UniProtKB:P07333

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07333&geneProductId=UniProtKB:P07333

transmembrane signaling receptor activity

1 reference

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07333&geneProductId=UniProtKB:P07333

transmembrane receptor protein tyrosine kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07333

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07333

9 May 2019

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07333

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07333

macrophage colony-stimulating factor receptor activity

6 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07333

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07333

9 May 2019

Expression of human colony-stimulating factor-1 (CSF-1) receptor in murine pluripotent hematopoietic NFS-60 cells induces long-term proliferation in response to CSF-1 without loss of erythroid differentiation potential

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07333

9 May 2019

Functional overlap but differential expression of CSF-1 and IL-34 in their CSF-1 receptor-mediated regulation of myeloid cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07333

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07333

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07333

protein tyrosine kinase activity

integral component of membrane

cell component

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07333

1 reference

9 May 2019

integral component of plasma membrane

1 reference

27 March 2018

Structural alteration of viral homologue of receptor proto-oncogene fms at carboxyl terminus

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07333&geneProductId=UniProtKB:P07333

cell surface

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07333

3 references

9 May 2019

9 May 2019

Colony stimulating factor-1 potentiates neuronal survival in cerebral cortex ischemic lesion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07333

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07333

nucleoplasm

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07333

1 reference

9 May 2019

plasma membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07333

5 references

9 May 2019

9 May 2019

Structural alteration of viral homologue of receptor proto-oncogene fms at carboxyl terminus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07333

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07333

9 May 2019

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07333

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07333

9 May 2019

intracellular membrane-bounded organelle

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07333

1 reference

9 May 2019

cytoplasm

1 reference

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07333&geneProductId=UniProtKB:P07333

receptor complex

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07333

CSF1-CSF1R complex

Structure of macrophage colony stimulating factor bound to FMS: diverse signaling assemblies of class III receptor tyrosine kinases

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07333

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07333

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07333

negative regulation of cell population proliferation

biological process

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07333

transmembrane receptor protein tyrosine kinase signaling pathway

mammary gland duct morphogenesis

1 reference

9 May 2019

Autocrine CSF-1R activation promotes Src-dependent disruption of mammary epithelial architecture

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07333

positive regulation of cell motility

1 reference

9 May 2019

Autocrine CSF-1R activation promotes Src-dependent disruption of mammary epithelial architecture

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07333

negative regulation of apoptotic process

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07333

signal transduction

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07333

axon guidance

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07333

multicellular organism development

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07333

monocyte differentiation

1 reference

9 May 2019

Blood monocytes: development, heterogeneity, and relationship with dendritic cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07333

macrophage differentiation

1 reference

9 May 2019

Blood monocytes: development, heterogeneity, and relationship with dendritic cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07333

olfactory bulb development

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07333

regulation of bone resorption

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07333

1 reference

9 May 2019

protein phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07333

1 reference

9 May 2019

positive regulation of protein tyrosine kinase activity

1 reference

9 May 2019

Activation of Src family kinases by colony stimulating factor-1, and their association with its receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07333

cell-cell junction maintenance

1 reference

9 May 2019

Autocrine CSF-1R activation promotes Src-dependent disruption of mammary epithelial architecture

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07333

innate immune response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07333

1 reference

9 May 2019

immune system process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07333

1 reference

9 May 2019

positive regulation of protein phosphorylation

1 reference

9 May 2019

Functional overlap but differential expression of CSF-1 and IL-34 in their CSF-1 receptor-mediated regulation of myeloid cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07333

forebrain neuron differentiation

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07333

phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07333

1 reference

9 May 2019

cellular response to macrophage colony-stimulating factor stimulus

Expression of human colony-stimulating factor-1 (CSF-1) receptor in murine pluripotent hematopoietic NFS-60 cells induces long-term proliferation in response to CSF-1 without loss of erythroid differentiation potential

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07333

9 May 2019

Functional overlap but differential expression of CSF-1 and IL-34 in their CSF-1 receptor-mediated regulation of myeloid cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07333

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07333

positive regulation of cell population proliferation

Autocrine CSF-1R activation promotes Src-dependent disruption of mammary epithelial architecture

3 references

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07333&geneProductId=UniProtKB:P07333

10 September 2018

Functional overlap but differential expression of CSF-1 and IL-34 in their CSF-1 receptor-mediated regulation of myeloid cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07333&geneProductId=UniProtKB:P07333

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07333&geneProductId=UniProtKB:P07333

cell population proliferation

cytokine-mediated signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07333

3 references

9 May 2019

9 May 2019

Functional overlap but differential expression of CSF-1 and IL-34 in their CSF-1 receptor-mediated regulation of myeloid cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07333

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07333

9 May 2019

hemopoiesis

1 reference

9 May 2019

Expression of human colony-stimulating factor-1 (CSF-1) receptor in murine pluripotent hematopoietic NFS-60 cells induces long-term proliferation in response to CSF-1 without loss of erythroid differentiation potential

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07333

negative regulation of signal transduction

1 reference

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07333&geneProductId=UniProtKB:P07333

cell differentiation

1 reference

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07333&geneProductId=UniProtKB:P07333

cellular response to macrophage colony-stimulating factor stimulus

Expression of human colony-stimulating factor-1 (CSF-1) receptor in murine pluripotent hematopoietic NFS-60 cells induces long-term proliferation in response to CSF-1 without loss of erythroid differentiation potential

4 references

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07333&geneProductId=UniProtKB:P07333

10 September 2018

Functional overlap but differential expression of CSF-1 and IL-34 in their CSF-1 receptor-mediated regulation of myeloid cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07333&geneProductId=UniProtKB:P07333

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07333&geneProductId=UniProtKB:P07333

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07333&geneProductId=UniProtKB:P07333

positive regulation of ERK1 and ERK2 cascade

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07333

3 references

9 May 2019

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07333

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07333

hematopoietic progenitor cell differentiation

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07333

transmembrane receptor protein tyrosine kinase signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07333

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07333

9 May 2019

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07333

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07333

positive regulation of cell population proliferation

Autocrine CSF-1R activation promotes Src-dependent disruption of mammary epithelial architecture

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07333

9 May 2019

Functional overlap but differential expression of CSF-1 and IL-34 in their CSF-1 receptor-mediated regulation of myeloid cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07333

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07333

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07333

osteoclast differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07333

3 references

9 May 2019

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07333

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07333

positive regulation of MAPK cascade

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07333

microglial cell proliferation

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07333

positive regulation by host of viral process

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07333

physically interacts with

1 reference

5664

17 August 2016

1 reference

7882

17 August 2016

1 reference

5657

17 August 2016

1 reference

5698

English

object of statement has role

17 August 2016

Emactuzumab

reaction inhibitor

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL3545370

enmd-981693

object of statement has role

reaction inhibitor

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL482968

EC enzyme number

2.7.10.1

1 reference

14 November 2015

http://www.uniprot.org/uniprot/P07333.txt?version=187

has part(s)

immunoglobulin domain

1 reference

immunoglobulin subtype 2

1 reference

tyrosine-protein kinase, active site

1 reference

protein kinase, ATP binding site

1 reference

protein kinase domain

1 reference

immunoglobulin-like domain

1 reference

tyrosine-protein kinase, catalytic domain

1 reference

serine-threonine/tyrosine-protein kinase, catalytic domain

1 reference

tyrosine-protein kinase, receptor class III, conserved site

1 reference

immunoglobulin subtype

1 reference

Identifiers

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016