Wikidata

(Q21101107)

English

Dynamin 1 like

mammalian protein found in Homo sapiens

  • Dymple
  • HdynIV
  • Dynamin-like protein
  • dynamin-1-like protein
  • dynamin-like protein IV
  • dynamin-related protein 1
  • dynamin family member proline-rich carboxyl-terminal domain less
  • DVLP
  • dynamin-like protein 4
  • Dnm1p/Vps1p-like protein
  • DNM1L
In more languages

Statements

molecular function
protein binding
determination method
IPI
20 references
stated in
UniProt
UniProt protein ID
O00429
retrieved
9 August 2016
language of work or name
English
retrieved
8 April 2019
stated in
Mff is an essential factor for mitochondrial recruitment of Drp1 during mitochondrial fission in mammalian cells
GOA
curator
UniProt
UniProt protein ID
O00429
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00429
determination method
IPI
retrieved
8 April 2019
stated in
Human dynamin-like protein interacts with the glycogen synthase kinase 3beta
GOA
curator
UniProt
UniProt protein ID
O00429
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00429
determination method
IPI
retrieved
8 April 2019
stated in
The mitochondrial protein hFis1 regulates mitochondrial fission in mammalian cells through an interaction with the dynamin-like protein DLP1
GOA
curator
UniProt
UniProt protein ID
O00429
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00429
determination method
IPI
retrieved
8 April 2019
stated in
Human MIEF1 recruits Drp1 to mitochondrial outer membranes and promotes mitochondrial fusion rather than fission
GOA
curator
UniProt
UniProt protein ID
O00429
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00429
determination method
IPI
retrieved
8 April 2019
stated in
MiD49 and MiD51, new components of the mitochondrial fission machinery
GOA
curator
UniProt
UniProt protein ID
O00429
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00429
determination method
IPI
retrieved
8 April 2019
stated in
SUMOylation of the mitochondrial fission protein Drp1 occurs at multiple nonconsensus sites within the B domain and is linked to its activity cycle
GOA
curator
UniProt
UniProt protein ID
O00429
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00429
determination method
IPI
retrieved
8 April 2019
stated in
Fis1, Mff, MiD49, and MiD51 mediate Drp1 recruitment in mitochondrial fission
GOA
curator
UniProt
UniProt protein ID
O00429
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00429
determination method
IPI
retrieved
8 April 2019
stated in
Dephosphorylation by calcineurin regulates translocation of Drp1 to mitochondria
GOA
curator
UniProt
UniProt protein ID
O00429
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00429
determination method
IPI
retrieved
8 April 2019
stated in
Parkinson's disease-associated mutant VPS35 causes mitochondrial dysfunction by recycling DLP1 complexes
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00429
determination method
IPI
retrieved
8 April 2019
stated in
Abnormal interaction between the mitochondrial fission protein Drp1 and hyperphosphorylated tau in Alzheimer's disease neurons: implications for mitochondrial dysfunction and neuronal damage
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00429
determination method
IPI
retrieved
8 April 2019
stated in
RAC3 is a pro-migratory co-activator of ERα
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00429
determination method
IPI
retrieved
8 April 2019
stated in
Leucine-rich repeat kinase 2 disturbs mitochondrial dynamics via Dynamin-like protein
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00429
determination method
IPI
retrieved
8 April 2019
stated in
Inhibition of excessive mitochondrial fission reduced aberrant autophagy and neuronal damage caused by LRRK2 G2019S mutation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00429
determination method
IPI
retrieved
8 April 2019
stated in
Functional interaction of Parkinson's disease-associated LRRK2 with members of the dynamin GTPase superfamily
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00429
determination method
IPI
retrieved
8 April 2019
stated in
Large-scale interaction profiling of PDZ domains through proteomic peptide-phage display using human and viral phage peptidomes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00429
determination method
IPI
retrieved
8 April 2019
stated in
LRRK2 regulates mitochondrial dynamics and function through direct interaction with DLP1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00429
determination method
IPI
retrieved
8 April 2019
stated in
Human MIEF1 recruits Drp1 to mitochondrial outer membranes and promotes mitochondrial fusion rather than fission
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00429
determination method
IPI
retrieved
8 April 2019
stated in
MiD49 and MiD51, new components of the mitochondrial fission machinery
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00429
determination method
IPI
retrieved
8 April 2019
stated in
SAMM50 Affects Mitochondrial Morphology through the Association of Drp1 in Mammalian Cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00429
determination method
IPI
cell component
mitochondrial outer membrane
determination method
IDA
TAS
IEA
7 references
stated in
UniProt
UniProt protein ID
O00429
retrieved
9 August 2016
language of work or name
English
retrieved
8 April 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00429
determination method
TAS
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
O00429
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00429
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00429
determination method
IEA
retrieved
8 April 2019
stated in
A novel de novo dominant negative mutation in DNM1L impairs mitochondrial fission and presents as childhood epileptic encephalopathy.
GOA
curator
UniProt
UniProt protein ID
O00429
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00429
determination method
IDA
retrieved
8 April 2019
stated in
Mff is an essential factor for mitochondrial recruitment of Drp1 during mitochondrial fission in mammalian cells
GOA
curator
UniProt
UniProt protein ID
O00429
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00429
determination method
IDA
retrieved
8 April 2019
stated in
Signal transducer and activator of transcription 2 deficiency is a novel disorder of mitochondrial fission
GOA
curator
UniProt
UniProt protein ID
O00429
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00429
determination method
IDA
cytoplasm
determination method
IBA
IDA
IEA
IMP
6 references
retrieved
8 April 2019
stated in
Mutations in DNM1L, as in OPA1, result indominant optic atrophy despite opposite effectson mitochondrial fusion and fission
GOA
curator
UniProt
UniProt protein ID
O00429
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00429
determination method
IMP
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
O00429
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00429
determination method
IEA
retrieved
8 April 2019
stated in
Mff is an essential factor for mitochondrial recruitment of Drp1 during mitochondrial fission in mammalian cells
GOA
curator
UniProt
UniProt protein ID
O00429
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00429
determination method
IDA
retrieved
8 April 2019
stated in
The dynamin-like GTPase DLP1 is essential for peroxisome division and is recruited to peroxisomes in part by PEX11
GOA
curator
UniProt
UniProt protein ID
O00429
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00429
determination method
IDA
retrieved
8 April 2019
stated in
An actin-dependent step in mitochondrial fission mediated by the ER-associated formin INF2
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00429
determination method
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00429
determination method
IBA
mitochondrion
determination method
IDA
IEA
IMP
11 references
retrieved
8 April 2019
stated in
Mutations in DNM1L, as in OPA1, result indominant optic atrophy despite opposite effectson mitochondrial fusion and fission
GOA
curator
UniProt
UniProt protein ID
O00429
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00429
determination method
IMP
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
O00429
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00429
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00429
determination method
IEA
retrieved
8 April 2019
stated in
The mitochondrial phosphatase PGAM5 functions at the convergence point of multiple necrotic death pathways
GOA
curator
UniProt
UniProt protein ID
O00429
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00429
determination method
IDA
retrieved
8 April 2019
stated in
Vps13D Encodes a Ubiquitin-Binding Protein that Is Required for the Regulation of Mitochondrial Size and Clearance.
GOA
curator
UniProt
UniProt protein ID
O00429
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00429
determination method
IDA
retrieved
8 April 2019
stated in
Adaptor proteins MiD49 and MiD51 can act independently of Mff and Fis1 in Drp1 recruitment and are specific for mitochondrial fission
GOA
curator
UniProt
UniProt protein ID
O00429
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00429
determination method
IDA
retrieved
8 April 2019
stated in
Interchangeable adaptors regulate mitochondrial dynamin assembly for membrane scission
GOA
curator
UniProt
UniProt protein ID
O00429
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00429
determination method
IDA
retrieved
8 April 2019
stated in
Parkinson's disease-associated mutant VPS35 causes mitochondrial dysfunction by recycling DLP1 complexes
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00429
determination method
IDA
retrieved
8 April 2019
stated in
Dynamin-related protein Drp1 is required for mitochondrial division in mammalian cells
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00429
determination method
IDA
retrieved
8 April 2019
stated in
Phosphatidic acid (PA)-preferring phospholipase A1 regulates mitochondrial dynamics
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00429
determination method
IDA
retrieved
8 April 2019
stated in
An actin-dependent step in mitochondrial fission mediated by the ER-associated formin INF2
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00429
determination method
IDA
cytosol
determination method
IDA
IEA
IMP
TAS
7 references
retrieved
8 April 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00429
determination method
TAS
retrieved
8 April 2019
stated in
Dynamin-related protein Drp1 is required for mitochondrial division in mammalian cells
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00429
determination method
IMP
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
O00429
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00429
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00429
determination method
IEA
retrieved
8 April 2019
stated in
The mitochondrial phosphatase PGAM5 functions at the convergence point of multiple necrotic death pathways
GOA
curator
UniProt
UniProt protein ID
O00429
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00429
determination method
IDA
retrieved
8 April 2019
stated in
Adaptor proteins MiD49 and MiD51 can act independently of Mff and Fis1 in Drp1 recruitment and are specific for mitochondrial fission
GOA
curator
UniProt
UniProt protein ID
O00429
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00429
determination method
IDA
retrieved
8 April 2019
stated in
GOA
curator
Human Protein Atlas
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00429
determination method
IDA
biological process
mitochondrial fission
determination method
IBA
IDA
IEA
IMP
8 references
retrieved
8 April 2019
stated in
Postnatal microcephaly and pain insensitivity due to a de novo heterozygous DNM1L mutation causing impaired mitochondrial fission and function
GOA
curator
UniProt
UniProt protein ID
O00429
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00429
determination method
IMP
retrieved
8 April 2019
stated in
A novel de novo dominant negative mutation in DNM1L impairs mitochondrial fission and presents as childhood epileptic encephalopathy.
GOA
curator
UniProt
UniProt protein ID
O00429
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00429
determination method
IMP
retrieved
8 April 2019
stated in
Adaptor proteins MiD49 and MiD51 can act independently of Mff and Fis1 in Drp1 recruitment and are specific for mitochondrial fission
GOA
curator
UniProt
UniProt protein ID
O00429
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00429
determination method
IMP
retrieved
8 April 2019
stated in
An actin-dependent step in mitochondrial fission mediated by the ER-associated formin INF2
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00429
determination method
IMP
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00429
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00429
determination method
IEA
retrieved
8 April 2019
stated in
Interchangeable adaptors regulate mitochondrial dynamin assembly for membrane scission
GOA
curator
UniProt
UniProt protein ID
O00429
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00429
determination method
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00429
determination method
IBA

Identifiers

Ensembl protein ID
 
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