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GDNF family receptor alpha like
mammalian protein found in Homo sapiens
GDNF family receptor alpha-like
GFRAL
IVFI9356
In more languages
edit
Statements
instance of
protein
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
Q6UXV0
part of
GDNF receptor alpha
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q6UXV0
glial cell line-derived neurotrophic factor receptor
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q6UXV0
GDNF/GAS1 domain, protein family
1 reference
based on heuristic
inferred from protein domain or family
found in taxon
Homo sapiens
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
Q6UXV0
encoded by
GFRAL
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
Q6UXV0
molecular function
signaling receptor activity
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6UXV0
determination method
IEA
protein binding
determination method
IPI
4 references
retrieved
8 April 2019
stated in
Non-homeostatic body weight regulation through a brainstem-restricted receptor for GDF15.
GOA
curator
UniProt
UniProt protein ID
Q6UXV0
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6UXV0
determination method
IPI
retrieved
8 April 2019
stated in
GFRAL is the receptor for GDF15 and the ligand promotes weight loss in mice and nonhuman primates
GOA
curator
UniProt
UniProt protein ID
Q6UXV0
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6UXV0
determination method
IPI
retrieved
8 April 2019
stated in
GFRAL is the receptor for GDF15 and is required for the anti-obesity effects of the ligand
GOA
curator
UniProt
UniProt protein ID
Q6UXV0
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6UXV0
determination method
IPI
retrieved
8 April 2019
stated in
The metabolic effects of GDF15 are mediated by the orphan receptor GFRAL.
GOA
curator
UniProt
UniProt protein ID
Q6UXV0
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6UXV0
determination method
IPI
glial cell-derived neurotrophic factor receptor activity
determination method
IDA
IEA
5 references
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6UXV0
determination method
IEA
retrieved
8 April 2019
stated in
Non-homeostatic body weight regulation through a brainstem-restricted receptor for GDF15.
GOA
curator
UniProt
UniProt protein ID
Q6UXV0
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6UXV0
determination method
IDA
retrieved
8 April 2019
stated in
GFRAL is the receptor for GDF15 and the ligand promotes weight loss in mice and nonhuman primates
GOA
curator
UniProt
UniProt protein ID
Q6UXV0
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6UXV0
determination method
IDA
retrieved
8 April 2019
stated in
GFRAL is the receptor for GDF15 and is required for the anti-obesity effects of the ligand
GOA
curator
UniProt
UniProt protein ID
Q6UXV0
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6UXV0
determination method
IDA
retrieved
8 April 2019
stated in
The metabolic effects of GDF15 are mediated by the orphan receptor GFRAL.
GOA
curator
UniProt
UniProt protein ID
Q6UXV0
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6UXV0
determination method
IDA
receptor tyrosine kinase binding
determination method
IEA
IPI
4 references
retrieved
8 April 2019
stated in
GFRAL is the receptor for GDF15 and the ligand promotes weight loss in mice and nonhuman primates
GOA
curator
UniProt
UniProt protein ID
Q6UXV0
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6UXV0
determination method
IPI
retrieved
8 April 2019
stated in
GFRAL is the receptor for GDF15 and is required for the anti-obesity effects of the ligand
GOA
curator
UniProt
UniProt protein ID
Q6UXV0
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6UXV0
determination method
IPI
retrieved
8 April 2019
stated in
Non-homeostatic body weight regulation through a brainstem-restricted receptor for GDF15.
GOA
curator
UniProt
UniProt protein ID
Q6UXV0
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6UXV0
determination method
IPI
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6UXV0
determination method
IEA
cell component
integral component of membrane
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q6UXV0
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6UXV0
determination method
IEA
plasma membrane
determination method
IEA
2 references
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q6UXV0
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6UXV0
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6UXV0
determination method
IEA
intracellular anatomical structure
determination method
IEA
1 reference
retrieved
10 September 2018
stated in
GOA
curator
Gene Ontology Consortium
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q6UXV0&geneProductId=UniProtKB:Q6UXV0
determination method
IEA
membrane
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q6UXV0
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6UXV0
determination method
IEA
external side of plasma membrane
determination method
IDA
1 reference
retrieved
5 June 2018
stated in
Non-homeostatic body weight regulation through a brainstem-restricted receptor for GDF15.
GOA
curator
UniProt
UniProt protein ID
Q6UXV0
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q6UXV0&geneProductId=UniProtKB:Q6UXV0
determination method
IDA
external side of plasma membrane
determination method
IBA
IDA
2 references
retrieved
8 April 2019
stated in
Non-homeostatic body weight regulation through a brainstem-restricted receptor for GDF15.
GOA
curator
UniProt
UniProt protein ID
Q6UXV0
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6UXV0
determination method
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6UXV0
determination method
IBA
receptor complex
determination method
IBA
1 reference
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6UXV0
determination method
IBA
biological process
negative regulation of neuron apoptotic process
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6UXV0
determination method
IEA
stress-activated protein kinase signaling cascade
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6UXV0
determination method
IEA
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6UXV0
determination method
IEA
reduction of food intake in response to dietary excess
determination method
IEA
ISS
2 references
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q6UXV0
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6UXV0
determination method
ISS
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6UXV0
determination method
IEA
glial cell-derived neurotrophic factor receptor signaling pathway
determination method
IDA
1 reference
retrieved
8 April 2019
stated in
Non-homeostatic body weight regulation through a brainstem-restricted receptor for GDF15.
GOA
curator
UniProt
UniProt protein ID
Q6UXV0
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6UXV0
determination method
IDA
positive regulation of MAPK cascade
determination method
IDA
1 reference
retrieved
8 April 2019
stated in
GFRAL is the receptor for GDF15 and is required for the anti-obesity effects of the ligand
GOA
curator
UniProt
UniProt protein ID
Q6UXV0
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6UXV0
determination method
IDA
positive regulation of protein kinase B signaling
determination method
IDA
1 reference
retrieved
8 April 2019
stated in
GFRAL is the receptor for GDF15 and the ligand promotes weight loss in mice and nonhuman primates
GOA
curator
UniProt
UniProt protein ID
Q6UXV0
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6UXV0
determination method
IDA
nervous system development
determination method
IBA
1 reference
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6UXV0
determination method
IBA
has part(s)
GDNF/GAS1
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q6UXV0
Identifiers
RefSeq protein ID
NP_997293
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
389400
UniProt protein ID
Q6UXV0
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
Q6UXV0
Ensembl protein ID
ENSP00000343636
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000343636
Sitelinks
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