(Q21102548)

http://www.ebi.ac.uk/interpro/protein/Q8TCT9

1 reference

18 July 2018

1 reference

18 July 2018

protein homodimerization activity

3 references

8 April 2019

Differential localization and identification of a critical aspartate suggest non-redundant proteolytic functions of the presenilin homologues SPPL2b and SPPL3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCT9

8 April 2019

Consensus analysis of signal peptide peptidase and homologous human aspartic proteases reveals opposite topology of catalytic domains compared with presenilins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCT9

8 April 2019

Intramembrane proteolytic cleavage by human signal peptide peptidase like 3 and malaria signal peptide peptidase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCT9

aspartic-type endopeptidase activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCT9

aspartic endopeptidase activity, intramembrane cleaving

5 references

8 April 2019

Signal peptide peptidase functions in ERAD to cleave the unfolded protein response regulator XBP1u

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCT9

8 April 2019

The TRC8 E3 ligase ubiquitinates MHC class I molecules before dislocation from the ER

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCT9

8 April 2019

Signal peptide peptidase functions in ERAD to cleave the unfolded protein response regulator XBP1u

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCT9

8 April 2019

Protein disulphide isomerase is required for signal peptide peptidase-mediated protein degradation

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCT9

8 April 2019

A proteome-scale map of the human interactome network

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCT9

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCT9

ubiquitin protein ligase binding

1 reference

8 April 2019

Signal peptide peptidase functions in ERAD to cleave the unfolded protein response regulator XBP1u

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCT9

aspartic endopeptidase activity, intramembrane cleaving

IPI

3 references

8 April 2019

Intramembrane proteolytic cleavage by human signal peptide peptidase like 3 and malaria signal peptide peptidase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCT9

8 April 2019

Signal peptide peptidase functions in ERAD to cleave the unfolded protein response regulator XBP1u

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCT9

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCT9

rough endoplasmic reticulum

cell component

endoplasmic reticulum membrane

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCT9

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCT9

8 April 2019

Signal peptide peptidase functions in ERAD to cleave the unfolded protein response regulator XBP1u

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCT9

integral component of cytoplasmic side of endoplasmic reticulum membrane

IC

1 reference

26 September 2017

Consensus analysis of signal peptide peptidase and homologous human aspartic proteases reveals opposite topology of catalytic domains compared with presenilins

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8TCT9&geneProductId=UniProtKB:Q8TCT9

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCT9

Derlin-1 retrotranslocation complex

1 reference

8 April 2019

Signal peptide peptidase functions in ERAD to cleave the unfolded protein response regulator XBP1u

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCT9

integral component of lumenal side of endoplasmic reticulum membrane

1 reference

26 September 2017

Consensus analysis of signal peptide peptidase and homologous human aspartic proteases reveals opposite topology of catalytic domains compared with presenilins

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8TCT9&geneProductId=UniProtKB:Q8TCT9

Golgi-associated vesicle membrane

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8TCT9&geneProductId=UniProtKB:Q8TCT9

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8TCT9&geneProductId=UniProtKB:Q8TCT9

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCT9

endoplasmic reticulum

4 references

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCT9

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCT9

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCT9

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCT9

integral component of cytoplasmic side of endoplasmic reticulum membrane

ISS

integral component of lumenal side of endoplasmic reticulum membrane

membrane protein proteolysis

1 reference

26 September 2017

Impas 1 possesses endoproteolytic activity against multipass membrane protein substrate cleaving the presenilin 1 holoprotein

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8TCT9&geneProductId=UniProtKB:Q8TCT9

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCT9

membrane protein proteolysis involved in retrograde protein transport, ER to cytosol

1 reference

8 April 2019

Signal peptide peptidase functions in ERAD to cleave the unfolded protein response regulator XBP1u

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCT9

membrane protein intracellular domain proteolysis

IMP

1 reference

8 April 2019

SPPL2a and SPPL2b promote intramembrane proteolysis of TNFalpha in activated dendritic cells to trigger IL-12 production

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCT9

membrane protein ectodomain proteolysis

IMP

1 reference

8 April 2019

Regulated intramembrane proteolysis of Bri2 (Itm2b) by ADAM10 and SPPL2a/SPPL2b

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCT9

protein homotetramerization

IMP

1 reference

8 April 2019

Signal peptide peptidase functions in ERAD to cleave the unfolded protein response regulator XBP1u

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCT9

signal peptide processing

TAS

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCT9