(Q24298773)

Signal peptide peptidase like 2A

1 reference

Signal peptide peptidase like 2C

1 reference

Integral membrane protein 2B

1 reference

ADAM metallopeptidase domain 10

1 reference

Signal peptide peptidase like 3

1 reference

Histocompatibility minor 13

1 reference

author

Paul Saftig

5

0 references

Elisabeth Kremmer

4

0 references

Christian Haass

6

object named as

Christian Haass

0 references

Regina Fluhrer

2

object named as

Regina Fluhrer

0 references

author name string

Lucas Martin

1

0 references

Karina Reiss

Journal of Biological Chemistry

3

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language of work or name

English

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publication date

18 January 2008

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published in

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volume

283

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page(s)

1644-52

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issue

3

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cites work

Intramembrane-cleaving proteases: controlled liberation of proteins and bioactive peptides

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706661200

Regulated intramembrane proteolysis: a control mechanism conserved from bacteria to humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706661200

Sterol-regulated release of SREBP-2 from cell membranes requires two sequential cleavages, one within a transmembrane segment

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706661200

SREBP-1, a membrane-bound transcription factor released by sterol-regulated proteolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706661200

Complementation cloning of S2P, a gene encoding a putative metalloprotease required for intramembrane cleavage of SREBPs

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706661200

ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706661200

Regulated intracellular ligand transport and proteolysis control EGF signal activation in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706661200

Drosophila rhomboid-1 defines a family of putative intramembrane serine proteases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706661200

Activation of EGFR and ERK by rhomboid signaling regulates the consolidation and maintenance of sleep in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706661200

Crystal structure of a rhomboid family intramembrane protease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706661200

Structural analysis of a rhomboid family intramembrane protease reveals a gating mechanism for substrate entry

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706661200

Structural basis for intramembrane proteolysis by rhomboid serine proteases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706661200

The crystal structure of the rhomboid peptidase from Haemophilus influenzae provides insight into intramembrane proteolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706661200

Open-cap conformation of intramembrane protease GlpG

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706661200

Identification of signal peptide peptidase, a presenilin-type aspartic protease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706661200

Identification of a novel family of presenilin homologues

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706661200

Novel class of polytopic proteins with domains associated with putative protease activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706661200

Alzheimer disease gamma-secretase: a complex story of GxGD-type presenilin proteases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706661200

The type 4 prepilin peptidases comprise a novel family of aspartic acid proteases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706661200

Take five--BACE and the gamma-secretase quartet conduct Alzheimer's amyloid beta-peptide generation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706661200

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706661200

Glycine 384 is required for presenilin-1 function and is conserved in bacterial polytopic aspartyl proteases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706661200

Notch signaling: from the outside in

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706661200

Presenilin clinical mutations can affect gamma-secretase activity by different mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706661200

Presenilins mediate a dual intramembranous gamma-secretase cleavage of Notch-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706661200

Differential localization and identification of a critical aspartate suggest non-redundant proteolytic functions of the presenilin homologues SPPL2b and SPPL3

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706661200

SPPL2a and SPPL2b promote intramembrane proteolysis of TNFalpha in activated dendritic cells to trigger IL-12 production

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706661200

Signal peptide peptidase is required for dislocation from the endoplasmic reticulum

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706661200

A gamma-secretase-like intramembrane cleavage of TNFalpha by the GxGD aspartyl protease SPPL2b

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706661200

The Fas ligand intracellular domain is released by ADAM10 and SPPL2a cleavage in T-cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706661200

A stop-codon mutation in the BRI gene associated with familial British dementia

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706661200

Furin mediates enhanced production of fibrillogenic ABri peptides in familial British dementia

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706661200

A decamer duplication in the 3' region of the BRI gene originates an amyloid peptide that is associated with dementia in a Danish kindred

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706661200

Familial cerebral amyloid angiopathy with nonneuritic amyloid plaque formation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706661200

The presenilin C-terminus is required for ER-retention, nicastrin-binding and gamma-secretase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706661200

Release of signal peptide fragments into the cytosol requires cleavage in the transmembrane region by a protease activity that is specifically blocked by a novel cysteine protease inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706661200

Functional gamma-secretase inhibitors reduce beta-amyloid peptide levels in brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706661200

The disintegrin-like metalloproteinase ADAM10 is involved in constitutive cleavage of CX3CL1 (fractalkine) and regulates CX3CL1-mediated cell-cell adhesion

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706661200

Axonal transport of British and Danish amyloid peptides via secretory vesicles

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706661200

Diverse cell surface protein ectodomains are shed by a system sensitive to metalloprotease inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706661200

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706661200

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706661200

Brefeldin A: insights into the control of membrane traffic and organelle structure

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706661200

BRICHOS: a conserved domain in proteins associated with dementia, respiratory distress and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706661200

Notch and Presenilin: regulated intramembrane proteolysis links development and degeneration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706661200

Reconstitution of gamma-secretase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706661200

Nicastrin functions as a gamma-secretase-substrate receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706661200

Stable association of presenilin derivatives and absence of presenilin interactions with APP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706661200

Activity-dependent isolation of the presenilin- gamma -secretase complex reveals nicastrin and a gamma substrate

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706661200

Gamma-secretase: proteasome of the membrane?

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706661200

Proteolytic processing of familial British dementia-associated BRI variants: evidence for enhanced intracellular accumulation of amyloidogenic peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706661200