(Q21122091)

English

Signal peptide peptidase like 3

mammalian protein found in Homo sapiens

SPPL3
signal peptide peptidase-like 3
SPP-like 3
IMP-2
presenilin homologous protein 1
PSH1
presenilin-like protein 4
intramembrane protease 2

In more languages

edit

Statements

1 reference

13 November 2019

Peptidase A22B, signal peptide peptidase

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q8TCT6

1 reference

13 November 2019

1 reference

13 November 2019

protein homodimerization activity

3 references

8 April 2019

Differential localization and identification of a critical aspartate suggest non-redundant proteolytic functions of the presenilin homologues SPPL2b and SPPL3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCT6

8 April 2019

Consensus analysis of signal peptide peptidase and homologous human aspartic proteases reveals opposite topology of catalytic domains compared with presenilins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCT6

8 April 2019

Intramembrane proteolytic cleavage by human signal peptide peptidase like 3 and malaria signal peptide peptidase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCT6

determination method

IDA

aspartic-type endopeptidase activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCT6

determination method

IEA

aspartic endopeptidase activity, intramembrane cleaving

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCT6

1 reference

8 April 2019

In vivo measurements of ethanol concentration in rabbit brain by 1H magnetic resonance spectroscopy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCT6

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCT6

determination method

IEA

aspartic endopeptidase activity, intramembrane cleaving

3 references

8 April 2019

Intramembrane proteolytic cleavage by human signal peptide peptidase like 3 and malaria signal peptide peptidase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCT6

8 April 2019

In vivo measurements of ethanol concentration in rabbit brain by 1H magnetic resonance spectroscopy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCT6

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCT6

determination method

IBA

cell component

rough endoplasmic reticulum

1 reference

8 April 2019

Differential localization and identification of a critical aspartate suggest non-redundant proteolytic functions of the presenilin homologues SPPL2b and SPPL3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCT6

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCT6

determination method

IEA

endoplasmic reticulum membrane

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCT6

determination method

IEA

intracellular membrane-bounded organelle

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCT6

determination method

IDA

integral component of cytoplasmic side of endoplasmic reticulum membrane

1 reference

27 March 2018

Consensus analysis of signal peptide peptidase and homologous human aspartic proteases reveals opposite topology of catalytic domains compared with presenilins

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8TCT6&geneProductId=UniProtKB:Q8TCT6

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCT6

determination method

IDA

endoplasmic reticulum

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCT6

determination method

IEA

Golgi-associated vesicle membrane

1 reference

27 March 2018

SPPL2a and SPPL2b promote intramembrane proteolysis of TNFalpha in activated dendritic cells to trigger IL-12 production

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8TCT6&geneProductId=UniProtKB:Q8TCT6

determination method

IDA

integral component of lumenal side of endoplasmic reticulum membrane

1 reference

27 March 2018

Consensus analysis of signal peptide peptidase and homologous human aspartic proteases reveals opposite topology of catalytic domains compared with presenilins

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8TCT6&geneProductId=UniProtKB:Q8TCT6

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8TCT6&geneProductId=UniProtKB:Q8TCT6

determination method

IBA

integral component of cytoplasmic side of endoplasmic reticulum membrane

determination method

IBA

IDA

integral component of lumenal side of endoplasmic reticulum membrane

positive regulation of protein dephosphorylation

1 reference

8 April 2019

A protease-independent function for SPPL3 in NFAT activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCT6

determination method

IMP

membrane protein proteolysis

1 reference

27 March 2018

In vivo measurements of ethanol concentration in rabbit brain by 1H magnetic resonance spectroscopy

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8TCT6&geneProductId=UniProtKB:Q8TCT6

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCT6

determination method

IEA

membrane protein ectodomain proteolysis

determination method

IMP

T cell receptor signaling pathway

3 references

signal peptide processing

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCT6

determination method

IBA

Identifiers

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

(Q21122091)

Signal peptide peptidase like 3

Statements

Identifiers

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)