(Q21173193)

English

Integral membrane protein 2B

mammalian protein found in Homo sapiens

imBRI2
ITM2B
ABri/ADan amyloid peptide
BRICHOS domain containing 2B
integral membrane protein 2B
transmembrane protein BRI
immature BRI2
Protein E25B
Bri

In more languages

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Statements

1 reference

18 July 2018

1 reference

inferred from GOA cell component → membrane

1 reference

18 July 2018

1 reference

18 July 2018

1 reference

26 September 2017

CD74 interacts with APP and suppresses the production of Abeta

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y287&geneProductId=UniProtKB:Q9Y287

3 references

8 April 2019

Regulated intramembrane proteolysis of Bri2 (Itm2b) by ADAM10 and SPPL2a/SPPL2b

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y287

8 April 2019

BRI2 interacts with amyloid precursor protein (APP) and regulates amyloid beta (Abeta) production

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y287

8 April 2019

A proteome-scale map of the human interactome network

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y287

1 reference

8 April 2019

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y287

determination method

IEA

cell component

integral component of organelle membrane

1 reference

8 April 2019

Furin mediates enhanced production of fibrillogenic ABri peptides in familial British dementia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y287

determination method

IDA

integral component of membrane

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y287

determination method

IEA

Golgi-associated vesicle membrane

1 reference

8 April 2019

Regulated intramembrane proteolysis of Bri2 (Itm2b) by ADAM10 and SPPL2a/SPPL2b

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y287

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y287

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y287

3 references

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y287&geneProductId=UniProtKB:Q9Y287

26 September 2017

Substrate requirements for SPPL2b-dependent regulated intramembrane proteolysis

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y287&geneProductId=UniProtKB:Q9Y287

26 September 2017

The α-helical content of the transmembrane domain of the British dementia protein-2 (Bri2) determines its processing by signal peptide peptidase-like 2b (SPPL2b)

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y287&geneProductId=UniProtKB:Q9Y287

2 references

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y287

determination method

IEA

extracellular exosome

4 references

26 September 2017

Proteomic analysis of podocyte exosome-enriched fraction from normal human urine

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y287&geneProductId=UniProtKB:Q9Y287

26 September 2017

Large-scale proteomics and phosphoproteomics of urinary exosomes

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y287&geneProductId=UniProtKB:Q9Y287

26 September 2017

Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT)

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y287&geneProductId=UniProtKB:Q9Y287

26 September 2017

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y287&geneProductId=UniProtKB:Q9Y287

determination method

IDA

intracellular membrane-bounded organelle

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y287

1 reference

8 April 2019

BRI2 (ITM2b) inhibits Abeta deposition in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y287

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y287

8 April 2019

The α-helical content of the transmembrane domain of the British dementia protein-2 (Bri2) determines its processing by signal peptide peptidase-like 2b (SPPL2b)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y287

8 April 2019

Substrate requirements for SPPL2b-dependent regulated intramembrane proteolysis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y287

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y287

determination method

IBA

extracellular exosome

3 references

8 April 2019

Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y287

8 April 2019

Large-scale proteomics and phosphoproteomics of urinary exosomes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y287

8 April 2019

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y287

determination method

HDA

biological process

nervous system development

1 reference

8 April 2019

A stop-codon mutation in the BRI gene associated with familial British dementia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y287

determination method

TAS

negative regulation of amyloid precursor protein biosynthetic process

determination method

IDA

negative regulation of amyloid precursor protein biosynthetic process

3 references

8 April 2019

BRI2 (ITM2b) inhibits Abeta deposition in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y287

8 April 2019

BRI2 interacts with amyloid precursor protein (APP) and regulates amyloid beta (Abeta) production

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y287

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y287

determination method

IBA

Identifiers

1 reference

18 May 2018

1 reference

18 July 2018

1 reference

1 reference

1 reference

1 reference

Transporter Classification Database ID

1.C.81.1.9

2 references

stated in

Transporter Classification database

retrieved

13 March 2020

stated in

Transporter Classification database

retrieved

29 April 2020

(Q21173193)

Integral membrane protein 2B

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Identifiers

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