(Q24311748)

Signal peptide peptidase like 2B

1 reference

Integral membrane protein 2C

1 reference

Integral membrane protein 2B

1 reference

Journal of Biological Chemistry

3

Christian Haass

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Regina Fluhrer

series ordinal

2

object named as

Regina Fluhrer

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author name string

Lucas Martin

series ordinal

1

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language of work or name

English

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publication date

27 February 2009

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published in

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volume

284

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page(s)

5662-70

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issue

9

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cites work

Identification of signal peptide peptidase, a presenilin-type aspartic protease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M807485200

Identification of a novel family of presenilin homologues

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M807485200

Intramembrane-cleaving aspartic proteases and disease: presenilins, signal peptide peptidase and their homologs

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M807485200

Alzheimer disease gamma-secretase: a complex story of GxGD-type presenilin proteases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M807485200

Intramembrane-cleaving proteases: controlled liberation of proteins and bioactive peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M807485200

Glycine 384 is required for presenilin-1 function and is conserved in bacterial polytopic aspartyl proteases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M807485200

C-terminal PAL motif of presenilin and presenilin homologues required for normal active site conformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M807485200

Transmembrane domain 9 of presenilin determines the dynamic conformation of the catalytic site of gamma-secretase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M807485200

The C-terminal PAL motif and transmembrane domain 9 of presenilin 1 are involved in the formation of the catalytic pore of the gamma-secretase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M807485200

Electron microscopic structure of purified, active gamma-secretase reveals an aqueous intramembrane chamber and two pores

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M807485200

Cryoelectron microscopy structure of purified gamma-secretase at 12 A resolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M807485200

Contribution of presenilin transmembrane domains 6 and 7 to a water-containing cavity in the gamma-secretase complex.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M807485200

Structure of the catalytic pore of gamma-secretase probed by the accessibility of substituted cysteines.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M807485200

A gamma-secretase-like intramembrane cleavage of TNFalpha by the GxGD aspartyl protease SPPL2b

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M807485200

Differential localization and identification of a critical aspartate suggest non-redundant proteolytic functions of the presenilin homologues SPPL2b and SPPL3

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M807485200

A C-terminal region of signal peptide peptidase defines a functional domain for intramembrane aspartic protease catalysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M807485200

Take five--BACE and the gamma-secretase quartet conduct Alzheimer's amyloid beta-peptide generation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M807485200

Reconstitution of gamma-secretase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M807485200

Nicastrin functions as a gamma-secretase-substrate receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M807485200

Requirement of PEN-2 for stabilization of the presenilin N-/C-terminal fragment heterodimer within the gamma-secretase complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M807485200

Both the sequence and length of the C terminus of PEN-2 are critical for intermolecular interactions and function of presenilin complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M807485200

SPPL2a and SPPL2b promote intramembrane proteolysis of TNFalpha in activated dendritic cells to trigger IL-12 production

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M807485200

The Fas ligand intracellular domain is released by ADAM10 and SPPL2a cleavage in T-cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M807485200

Regulated intramembrane proteolysis of Bri2 (Itm2b) by ADAM10 and SPPL2a/SPPL2b

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M807485200

The catalytic core of gamma-secretase: presenilin revisited

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M807485200

Requirements for presenilin-dependent cleavage of notch and other transmembrane proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M807485200

Activity-dependent isolation of the presenilin- gamma -secretase complex reveals nicastrin and a gamma substrate

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M807485200

Glu(332) in the Nicastrin ectodomain is essential for gamma-secretase complex maturation but not for its activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M807485200

Requirements for signal peptide peptidase-catalyzed intramembrane proteolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M807485200

The presenilin C-terminus is required for ER-retention, nicastrin-binding and gamma-secretase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M807485200

Release of signal peptide fragments into the cytosol requires cleavage in the transmembrane region by a protease activity that is specifically blocked by a novel cysteine protease inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M807485200

Intramembrane proteolysis by gamma-secretase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M807485200

cDNA sequence analysis, chromosomal assignment and expression pattern of the gene coding for integral membrane protein 2B.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M807485200

Beta-amyloid protein converting enzyme 1 and brain-specific type II membrane protein BRI3: binding partners processed by furin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M807485200

Constitutive and regulated alpha-secretase cleavage of Alzheimer's amyloid precursor protein by a disintegrin metalloprotease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M807485200

Gamma-secretase: proteasome of the membrane?

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M807485200

Mechanism of the cleavage specificity of Alzheimer's disease gamma-secretase identified by phenylalanine-scanning mutagenesis of the transmembrane domain of the amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M807485200

The GxGD motif of presenilin contributes to catalytic function and substrate identification of gamma-secretase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M807485200

A single-amino-acid mutation in hepatitis C virus NS5A disrupting FKBP8 interaction impairs viral replication

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M807485200

Amyloid beta-protein precursor juxtamembrane domain regulates specificity of gamma-secretase-dependent cleavages

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M807485200

Beta-amyloid precursor protein cleavage by a membrane-bound protease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M807485200

Homophilic interactions of the amyloid precursor protein (APP) ectodomain are regulated by the loop region and affect beta-secretase cleavage of APP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M807485200

Homodimerization of amyloid precursor protein and its implication in the amyloidogenic pathway of Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M807485200

GxxxG motifs within the amyloid precursor protein transmembrane sequence are critical for the etiology of Abeta42.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M807485200