(Q40077211)

17 September 2017

title

Amyloid beta-protein precursor juxtamembrane domain regulates specificity of gamma-secretase-dependent cleavages (English)

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17 September 2017

Zhao Ren

1

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17 September 2017

Dale Schenk

series ordinal

2

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17 September 2017

Guriqbal S Basi

series ordinal

3

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17 September 2017

I Paul Shapiro

series ordinal

4

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17 September 2017

language of work or name

English

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publication date

21 September 2007

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Journal of Biological Chemistry

17 September 2017

published in

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17 September 2017

volume

282

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17 September 2017

issue

48

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17 September 2017

page(s)

35350-35360

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Purification and cloning of amyloid precursor protein beta-secretase from human brain

17 September 2017

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A novel epsilon-cleavage within the transmembrane domain of the Alzheimer amyloid precursor protein demonstrates homology with Notch processing

21 January 2018

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Aph-1, Pen-2, and Nicastrin with Presenilin generate an active gamma-Secretase complex

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21 January 2018

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Presenilins mediate a dual intramembranous gamma-secretase cleavage of Notch-1.

21 January 2018

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Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

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Activity-dependent isolation of the presenilin- gamma -secretase complex reveals nicastrin and a gamma substrate

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Generation of amyloid beta protein from its precursor is sequence specific

21 January 2018

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Secretion of long Abeta-related peptides processed at epsilon-cleavage site is dependent on the alpha-secretase pre-cutting

21 January 2018

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kuzbanian-mediated cleavage of Drosophila Notch

21 January 2018

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Proteolysis of chimeric beta-amyloid precursor proteins containing the Notch transmembrane domain yields amyloid beta-like peptides

21 January 2018

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Nicastrin functions as a gamma-secretase-substrate receptor

21 January 2018

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Membrane inserted APP fragments containing the beta A4 sequence of Alzheimer's disease do not aggregate

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A second cytotoxic proteolytic peptide derived from amyloid beta-protein precursor

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Chronic treatment with the gamma-secretase inhibitor LY-411,575 inhibits beta-amyloid peptide production and alters lymphopoiesis and intestinal cell differentiation

21 January 2018

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Modulation of notch processing by gamma-secretase inhibitors causes intestinal goblet cell metaplasia and induction of genes known to specify gut secretory lineage differentiation

21 January 2018

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Mutations in APP have independent effects on Abeta and CTFgamma generation

21 January 2018

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APP substitutions V715F and L720P alter PS1 conformation and differentially affect Abeta and AICD generation

21 January 2018

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A loss of function mutant of the presenilin homologue SEL-12 undergoes aberrant endoproteolysis in Caenorhabditis elegans and increases abeta 42 generation in human cells

21 January 2018

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Presenilin-1 mutations of leucine 166 equally affect the generation of the Notch and APP intracellular domains independent of their effect on Abeta 42 production

21 January 2018

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Presenilin 1 mutations activate gamma 42-secretase but reciprocally inhibit epsilon-secretase cleavage of amyloid precursor protein (APP) and S3-cleavage of notch

21 January 2018

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Familial Alzheimer's disease presenilin 1 mutations cause alterations in the conformation of presenilin and interactions with amyloid precursor protein.

21 January 2018

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A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity

21 January 2018

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Nonsteroidal anti-inflammatory drugs lower Abeta42 and change presenilin 1 conformation

21 January 2018

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21 January 2018

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Presenilin complexes with the C-terminal fragments of amyloid precursor protein at the sites of amyloid beta-protein generation

21 January 2018

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21 January 2018

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21 January 2018

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gamma-Cleavage is dependent on zeta-cleavage during the proteolytic processing of amyloid precursor protein within its transmembrane domain

21 January 2018

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Truncated carboxyl-terminal fragments of beta-amyloid precursor protein are processed to amyloid beta-proteins 40 and 42.

21 January 2018

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APPepsilon, the epsilon-secretase-derived N-terminal product of the beta-amyloid precursor protein, behaves as a type I protein and undergoes alpha-, beta-, and gamma-secretase cleavages

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702739200

Analysis of transmembrane domain mutants is consistent with sequential cleavage of Notch by gamma-secretase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702739200

TMP21 is a presenilin complex component that modulates gamma-secretase but not epsilon-secretase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702739200

Self-refinement of Notch activity through the transmembrane protein Crumbs: modulation of gamma-secretase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702739200

21 January 2018

Identifiers

DOI

10.1074/JBC.M702739200

1 reference

17 September 2017

1 reference