(Q53628647)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16597736%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

title

The GxGD motif of presenilin contributes to catalytic function and substrate identification of gamma-secretase (English)

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19 January 2020

3

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19 January 2020

author name string

Aya Yamasaki

1

1 reference

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19 January 2020

Stefan Eimer

2

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19 January 2020

Agata Smialowska

4

1 reference

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19 January 2020

Christoph Kaether

5

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19 January 2020

Ralf Baumeister

6

1 reference

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19 January 2020

Harald Steiner

8

1 reference

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19 January 2020

Christian Haass

7

1 reference

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19 January 2020

language of work or name

English

0 references

publication date

1 April 2006

1 reference

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19 January 2020

published in

Journal of Neuroscience

1 reference

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19 January 2020

volume

26

1 reference

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19 January 2020

issue

14

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19 January 2020

page(s)

3821-3828

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Reverse genetic analysis of Caenorhabditis elegans presenilins reveals redundant but unequal roles for sel-12 and hop-1 in Notch-pathway signaling

19 January 2020

cites work

1 reference

12 December 2020

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

1 reference

12 December 2020

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

1 reference

12 December 2020

A loss of function mutation of presenilin-2 interferes with amyloid beta-peptide production and notch signaling

1 reference

12 December 2020

Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency

1 reference

12 December 2020

The type 4 prepilin peptidases comprise a novel family of aspartic acid proteases

1 reference

12 December 2020

Total inactivation of gamma-secretase activity in presenilin-deficient embryonic stem cells.

1 reference

12 December 2020

Presenilins are required for gamma-secretase cleavage of beta-APP and transmembrane cleavage of Notch-1

1 reference

12 December 2020

Presenilin is required for proper morphology and function of neurons in C. elegans

1 reference

12 December 2020

Requirements for presenilin-dependent cleavage of notch and other transmembrane proteins.

1 reference

12 December 2020

Glycine 384 is required for presenilin-1 function and is conserved in bacterial polytopic aspartyl proteases

1 reference

12 December 2020

The first proline of PALP motif at the C terminus of presenilins is obligatory for stabilization, complex formation, and gamma-secretase activities of presenilins

1 reference

12 December 2020

Interaction with telencephalin and the amyloid precursor protein predicts a ring structure for presenilins

1 reference

12 December 2020

Activity-dependent isolation of the presenilin- gamma -secretase complex reveals nicastrin and a gamma substrate

1 reference

12 December 2020

Presenilin 1 is required for maturation and cell surface accumulation of nicastrin

1 reference

12 December 2020

Presenilin and nicastrin regulate each other and determine amyloid beta-peptide production via complex formation

1 reference

12 December 2020

Linear non-competitive inhibition of solubilized human gamma-secretase by pepstatin A methylester, L685458, sulfonamides, and benzodiazepines

1 reference

12 December 2020

Identification of signal peptide peptidase, a presenilin-type aspartic protease

1 reference

12 December 2020

aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation

1 reference

12 December 2020

PEN-2 is an integral component of the gamma-secretase complex required for coordinated expression of presenilin and nicastrin

1 reference

12 December 2020

Presenilins mediate a dual intramembranous gamma-secretase cleavage of Notch-1.

1 reference

12 December 2020

The mechanism of gamma-secretase activities through high molecular weight complex formation of presenilins is conserved in Drosophila melanogaster and mammals

1 reference

12 December 2020

Alzheimer disease gamma-secretase: a complex story of GxGD-type presenilin proteases

1 reference

12 December 2020

The role of presenilin cofactors in the gamma-secretase complex

1 reference

12 December 2020

Reconstitution of gamma-secretase activity

1 reference

12 December 2020

Aph-1, Pen-2, and Nicastrin with Presenilin generate an active gamma-Secretase complex

1 reference

12 December 2020

The mechanism of gamma-secretase: multiple inhibitor binding sites for transition state analogs and small molecule inhibitors

1 reference

12 December 2020

γ-Secretase is a membrane protein complex comprised of presenilin, nicastrin, aph-1, and pen-2

1 reference

12 December 2020

Regulated hyperaccumulation of presenilin-1 and the "gamma-secretase" complex. Evidence for differential intramembranous processing of transmembrane subatrates

1 reference

12 December 2020

In vitro characterization of the presenilin-dependent gamma-secretase complex using a novel affinity ligand.

1 reference

12 December 2020

Presenilins mutated at Asp-257 or Asp-385 restore Pen-2 expression and Nicastrin glycosylation but remain catalytically inactive in the absence of wild type Presenilin

1 reference

12 December 2020

Take five--BACE and the gamma-secretase quartet conduct Alzheimer's amyloid beta-peptide generation.

1 reference

12 December 2020

Notch signaling: control of cell communication and cell fate

1 reference

12 December 2020

Conserved "PAL" sequence in presenilins is essential for gamma-secretase activity, but not required for formation or stabilization of gamma-secretase complexes

1 reference

12 December 2020

Gamma-secretase: proteasome of the membrane?

1 reference

12 December 2020

Mutation of a putative sperm membrane protein in Caenorhabditis elegans prevents sperm differentiation but not its associated meiotic divisions

1 reference

12 December 2020

Identification of distinct gamma-secretase complexes with different APH-1 variants

1 reference

12 December 2020

Coordinated and widespread expression of gamma-secretase in vivo: evidence for size and molecular heterogeneity

1 reference

12 December 2020

The presenilin C-terminus is required for ER-retention, nicastrin-binding and gamma-secretase activity

1 reference

12 December 2020

The initial substrate-binding site of gamma-secretase is located on presenilin near the active site

1 reference

12 December 2020

Evidence that the COOH terminus of human presenilin 1 is located in extracytoplasmic space

1 reference

12 December 2020

A novel transmembrane topology of presenilin based on reconciling experimental and computational evidence

1 reference

12 December 2020

Uncovering gamma-secretase

1 reference

12 December 2020

Differential localization and identification of a critical aspartate suggest non-redundant proteolytic functions of the presenilin homologues SPPL2b and SPPL3

1 reference

12 December 2020

A nine-transmembrane domain topology for presenilin 1

1 reference

12 December 2020

Nicastrin functions as a gamma-secretase-substrate receptor

1 reference

12 December 2020

Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene

1 reference

12 December 2020

Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo

1 reference

12 December 2020

Assessment of normal and mutant human presenilin function in Caenorhabditis elegans

1 reference

12 December 2020

Microtubule-dependent transport of secretory vesicles visualized in real time with a GFP-tagged secretory protein

1 reference

12 December 2020

HOP-1, a Caenorhabditis elegans presenilin, appears to be functionally redundant with SEL-12 presenilin and to facilitate LIN-12 and GLP-1 signaling

1 reference

12 December 2020

Cellular expression and proteolytic processing of presenilin proteins is developmentally regulated during neuronal differentiation.

1 reference

12 December 2020

Human presenilin-1, but not familial Alzheimer's disease (FAD) mutants, facilitate Caenorhabditis elegans Notch signalling independently of proteolytic processing.

1 reference

12 December 2020

The presenilin protein family member SPE-4 localizes to an ER/Golgi derived organelle and is required for proper cytoplasmic partitioning during Caenorhabditis elegans spermatogenesis

1 reference

12 December 2020

10.1523/JNEUROSCI.5354-05.2006

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16597736%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

1 reference

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19 January 2020

1 reference