(Q44488079)

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Regulated hyperaccumulation of presenilin-1 and the "gamma-secretase" complex. Evidence for differential intramembranous processing of transmembrane subatrates

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

3 December 2017

Regulated hyperaccumulation of presenilin-1 and the "gamma-secretase" complex. Evidence for differential intramembranous processing of transmembrane subatrates (English)

1 reference

Europe PubMed Central

PubMed publication ID

3 December 2017

transmembrane protein

0 references

author name string

Seong-Hun Kim

1

1 reference

Europe PubMed Central

PubMed publication ID

3 December 2017

Takeshi Ikeuchi

2

1 reference

Europe PubMed Central

PubMed publication ID

3 December 2017

Chunjiang Yu

3

1 reference

Europe PubMed Central

PubMed publication ID

3 December 2017

Sangram S Sisodia

4

1 reference

Europe PubMed Central

PubMed publication ID

3 December 2017

language of work or name

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publication date

23 June 2003

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Europe PubMed Central

PubMed publication ID

3 December 2017

number of pages

11

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based on heuristic

inferred from page(s)

Journal of Biological Chemistry

1 reference

Europe PubMed Central

PubMed publication ID

3 December 2017

278

1 reference

Europe PubMed Central

PubMed publication ID

3 December 2017

36

1 reference

Europe PubMed Central

PubMed publication ID

3 December 2017

33992-34002

1 reference

Europe PubMed Central

PubMed publication ID

3 December 2017

Mutant genes in familial Alzheimer's disease and transgenic models

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305834200

21 January 2018

Notch and presenilins in vertebrates and invertebrates: implications for neuronal development and degeneration

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305834200

21 January 2018

gamma-Secretase, Notch, Abeta and Alzheimer's disease: where do the presenilins fit in?

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305834200

21 January 2018

Total inactivation of gamma-secretase activity in presenilin-deficient embryonic stem cells.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305834200

21 January 2018

Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305834200

21 January 2018

Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305834200

21 January 2018

Aspartyl protease inhibitor pepstatin binds to the presenilins of Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305834200

21 January 2018

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305834200

21 January 2018

A loss of function mutation of presenilin-2 interferes with amyloid beta-peptide production and notch signaling

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305834200

21 January 2018

Cell surface presenilin-1 participates in the gamma-secretase-like proteolysis of Notch

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305834200

21 January 2018

Aspartate mutations in presenilin and gamma-secretase inhibitors both impair notch1 proteolysis and nuclear translocation with relative preservation of notch1 signaling

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305834200

21 January 2018

Biochemistry. Intramembrane proteases--mixing oil and water

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305834200

21 January 2018

Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305834200

21 January 2018

Evidence that levels of presenilins (PS1 and PS2) are coordinately regulated by competition for limiting cellular factors.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305834200

21 January 2018

Hyperaccumulation of FAD-linked presenilin 1 variants in vivo.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305834200

21 January 2018

Endoproteolytic processing and stabilization of wild-type and mutant presenilin

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305834200

21 January 2018

Stable association of presenilin derivatives and absence of presenilin interactions with APP.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305834200

21 January 2018

The proteolytic fragments of the Alzheimer's disease-associated presenilin-1 form heterodimers and occur as a 100-150-kDa molecular mass complex

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305834200

21 January 2018

Evidence for phosphorylation and oligomeric assembly of presenilin 1.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305834200

21 January 2018

Presenilin and nicastrin regulate each other and determine amyloid beta-peptide production via complex formation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305834200

21 January 2018

The presenilin 1 protein is a component of a high molecular weight intracellular complex that contains beta-catenin

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305834200

21 January 2018

Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305834200

21 January 2018

γ-Secretase is a membrane protein complex comprised of presenilin, nicastrin, aph-1, and pen-2

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305834200

21 January 2018

Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305834200

21 January 2018

aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305834200

21 January 2018

APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryos

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305834200

21 January 2018

Presenilin-1 affects trafficking and processing of betaAPP and is targeted in a complex with nicastrin to the plasma membrane

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305834200

21 January 2018

Complex N-glycosylated form of nicastrin is stabilized and selectively bound to presenilin fragments.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305834200

21 January 2018

Mature glycosylation and trafficking of nicastrin modulate its binding to presenilins

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305834200

21 January 2018

Complex N-linked glycosylated nicastrin associates with active gamma-secretase and undergoes tight cellular regulation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305834200

21 January 2018

Localization of presenilin-nicastrin complexes and gamma-secretase activity to the trans-Golgi network

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305834200

21 January 2018

Nicastrin is required for gamma-secretase cleavage of the Drosophila Notch receptor

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305834200

21 January 2018

Drosophila nicastrin is essential for the intramembranous cleavage of notch

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305834200

21 January 2018

Nicastrin is required for Presenilin-mediated transmembrane cleavage in Drosophila

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305834200

21 January 2018

Mammalian APH-1 interacts with presenilin and nicastrin and is required for intramembrane proteolysis of amyloid-beta precursor protein and Notch

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305834200

21 January 2018

The role of presenilin cofactors in the gamma-secretase complex

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305834200

21 January 2018

PEN-2 is an integral component of the gamma-secretase complex required for coordinated expression of presenilin and nicastrin

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305834200

21 January 2018

Presenilin 1 is required for maturation and cell surface accumulation of nicastrin

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305834200

21 January 2018

gamma-Secretase activity requires the presenilin-dependent trafficking of nicastrin through the Golgi apparatus but not its complex glycosylation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305834200

21 January 2018

APH-1 interacts with mature and immature forms of presenilins and nicastrin and may play a role in maturation of presenilin.nicastrin complexes

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305834200

21 January 2018

Characterization of a presenilin-mediated amyloid precursor protein carboxyl-terminal fragment gamma. Evidence for distinct mechanisms involved in gamma -secretase processing of the APP and Notch1 transmembrane domains

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305834200

21 January 2018

Presenilin-dependent gamma-secretase processing of beta-amyloid precursor protein at a site corresponding to the S3 cleavage of Notch

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305834200

21 January 2018

Generation of APLP2 KO mice and early postnatal lethality in APLP2/APP double KO mice

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305834200

21 January 2018

PEN-2 and APH-1 coordinately regulate proteolytic processing of presenilin 1.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305834200

21 January 2018

Amyloid production and deposition in mutant amyloid precursor protein and presenilin-1 yeast artificial chromosome transgenic mice.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305834200

21 January 2018

Protease nexin-II, a potent antichymotrypsin, shows identity to amyloid beta-protein precursor

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305834200

21 January 2018

High-efficiency transformation of mammalian cells by plasmid DNA

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305834200

21 January 2018

Multiple effects of aspartate mutant presenilin 1 on the processing and trafficking of amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305834200

21 January 2018

Specificity of RNA maturation pathways: RNAs transcribed by RNA polymerase III are not substrates for splicing or polyadenylation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305834200

21 January 2018

Furin mediates enhanced production of fibrillogenic ABri peptides in familial British dementia

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305834200

21 January 2018

Metabolism of the "Swedish" amyloid precursor protein variant in neuro2a (N2a) cells. Evidence that cleavage at the "beta-secretase" site occurs in the golgi apparatus

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305834200

21 January 2018

Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305834200

21 January 2018

Mutations at the P1' position of Notch1 decrease intracellular domain stability rather than cleavage by gamma-secretase.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305834200

21 January 2018

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305834200

21 January 2018

Reconstitution of gamma-secretase activity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305834200

21 January 2018

GSK-3alpha regulates production of Alzheimer's disease amyloid-beta peptides

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305834200

21 January 2018

Presenilin Proteins Undergo Heterogeneous Endoproteolysis between Thr291and Ala299and Occur as Stable N- and C-Terminal Fragments in Normal and Alzheimer Brain Tissue

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305834200

21 January 2018

Presenilins are required for gamma-secretase cleavage of beta-APP and transmembrane cleavage of Notch-1

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305834200

21 January 2018

The transmembrane aspartates in presenilin 1 and 2 are obligatory for gamma-secretase activity and amyloid beta-protein generation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305834200

21 January 2018

Endoproteolytic cleavage and proteasomal degradation of presenilin 2 in transfected cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305834200

21 January 2018

Distinct intramembrane cleavage of the beta-amyloid precursor protein family resembling gamma-secretase-like cleavage of Notch

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305834200

21 January 2018

Identifiers

10.1074/JBC.M305834200

1 reference

Europe PubMed Central

PubMed publication ID

3 December 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

3 December 2017

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