(Q34609917)

3 August 2017

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title

gamma-Secretase, Notch, Abeta and Alzheimer's disease: where do the presenilins fit in? (English)

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Peter Henry St George-Hyslop

3 August 2017

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object named as

Peter H St George-Hyslop

series ordinal

2

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author name string

Sangram S Sisodia

series ordinal

1

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PubMed ID

11967558

3 August 2017

language of work or name

English

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publication date

1 April 2002

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Nature Reviews Neuroscience

3 August 2017

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3 August 2017

3

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3 August 2017

281-290

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3 August 2017

4

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https://scigraph.springernature.com/pub.10.1038/nrn785

3 August 2017

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

1 reference

Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state

31 March 2020

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Presenilin 1 controls gamma-secretase processing of amyloid precursor protein in pre-golgi compartments of hippocampal neurons

31 March 2020

1 reference

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31 March 2020

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Cell surface presenilin-1 participates in the gamma-secretase-like proteolysis of Notch

31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

1 reference

Presenilins are required for gamma-secretase cleavage of beta-APP and transmembrane cleavage of Notch-1

31 March 2020

1 reference

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31 March 2020

1 reference

A ligand-induced extracellular cleavage regulates gamma-secretase-like proteolytic activation of Notch1

31 March 2020

1 reference

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31 March 2020

1 reference

Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain

31 March 2020

1 reference

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31 March 2020

1 reference

Presenilins, processing of beta-amyloid precursor protein, and notch signaling.

31 March 2020

1 reference

Presenilin 1 is required for Notch1 and DII1 expression in the paraxial mesoderm

31 March 2020

1 reference

Skeletal and CNS defects in Presenilin-1-deficient mice

31 March 2020

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Mice lacking both presenilin genes exhibit early embryonic patterning defects

31 March 2020

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Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency

31 March 2020

1 reference

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

31 March 2020

1 reference

gamma -Secretase cleavage and nuclear localization of ErbB-4 receptor tyrosine kinase

31 March 2020

1 reference

Wild-type and mutated nicastrins do not display aminopeptidase M- and B-like activities.

31 March 2020

1 reference

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

31 March 2020

1 reference

Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1

31 March 2020

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Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1.

31 March 2020

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Glycine 384 is required for presenilin-1 function and is conserved in bacterial polytopic aspartyl proteases

31 March 2020

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Embryonic lethality in mice homozygous for a processing-deficient allele of Notch1.

31 March 2020

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Mutations in the transmembrane domain of APP altering gamma-secretase specificity

31 March 2020

1 reference

Characterization of a presenilin-mediated amyloid precursor protein carboxyl-terminal fragment gamma. Evidence for distinct mechanisms involved in gamma -secretase processing of the APP and Notch1 transmembrane domains

31 March 2020

1 reference

Distinct intramembrane cleavage of the beta-amyloid precursor protein family resembling gamma-secretase-like cleavage of Notch

31 March 2020

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Separation of presenilin function in amyloid beta-peptide generation and endoproteolysis of Notch

31 March 2020

1 reference

New protease inhibitors prevent gamma-secretase-mediated production of Abeta40/42 without affecting Notch cleavage

31 March 2020

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Multiple effects of aspartate mutant presenilin 1 on the processing and trafficking of amyloid precursor protein

31 March 2020

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Presenilin-1 differentially facilitates endoproteolysis of the beta-amyloid precursor protein and Notch

31 March 2020

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Presenilin 1 regulates pharmacologically distinct gamma -secretase activities. Implications for the role of presenilin in gamma -secretase cleavage

31 March 2020

1 reference

The first proline of PALP motif at the C terminus of presenilins is obligatory for stabilization, complex formation, and gamma-secretase activities of presenilins

31 March 2020

1 reference

Mutagenesis identifies new signals for beta-amyloid precursor protein endocytosis, turnover, and the generation of secreted fragments, including Abeta42

31 March 2020

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Interaction with telencephalin and the amyloid precursor protein predicts a ring structure for presenilins

31 March 2020

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Transport-Dependent Proteolysis of SREBP

31 March 2020

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BACE1 is the major beta-secretase for generation of Abeta peptides by neurons

31 March 2020

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The brain's susceptibility to amyloid plaques

31 March 2020

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Gamma -secretase inhibitors repress thymocyte development

31 March 2020

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Piecing together Alzheimer's.

31 March 2020

1 reference

31 March 2020

Identifiers

DOI

10.1038/NRN785

1 reference

PubMed ID

11967558

Dimensions Publication ID

3 August 2017

0 references

1 reference

PubMed ID

11967558