(Q40795556)

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The first proline of PALP motif at the C terminus of presenilins is obligatory for stabilization, complex formation, and gamma-secretase activities of presenilins

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Europe PubMed Central

PubMed publication ID

23 September 2017

The first proline of PALP motif at the C terminus of presenilins is obligatory for stabilization, complex formation, and gamma-secretase activities of presenilins (English)

1 reference

Europe PubMed Central

PubMed publication ID

23 September 2017

1

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Europe PubMed Central

PubMed publication ID

23 September 2017

author name string

Watabiki T

2

1 reference

Europe PubMed Central

PubMed publication ID

23 September 2017

Takikawa R

3

1 reference

Europe PubMed Central

PubMed publication ID

23 September 2017

Morohashi Y

4

1 reference

Europe PubMed Central

PubMed publication ID

23 September 2017

Takasugi N

5

1 reference

Europe PubMed Central

PubMed publication ID

23 September 2017

Kopan R

6

1 reference

Europe PubMed Central

PubMed publication ID

23 September 2017

De Strooper B

7

1 reference

Europe PubMed Central

PubMed publication ID

23 September 2017

Iwatsubo T

8

1 reference

Europe PubMed Central

PubMed publication ID

23 September 2017

language of work or name

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publication date

29 June 2001

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Europe PubMed Central

PubMed publication ID

23 September 2017

Journal of Biological Chemistry

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Europe PubMed Central

PubMed publication ID

23 September 2017

276

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Europe PubMed Central

PubMed publication ID

23 September 2017

35

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Europe PubMed Central

PubMed publication ID

23 September 2017

33273-33281

1 reference

Europe PubMed Central

PubMed publication ID

23 September 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M011152200

21 January 2018

An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M011152200

21 January 2018

Seeding "one-dimensional crystallization" of amyloid: a pathogenic mechanism in Alzheimer's disease and scrapie?

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M011152200

21 January 2018

Visualization of A beta 42(43) and A beta 40 in senile plaques with end-specific A beta monoclonals: evidence that an initially deposited species is A beta 42(43).

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M011152200

21 January 2018

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M011152200

21 January 2018

Total inactivation of gamma-secretase activity in presenilin-deficient embryonic stem cells.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M011152200

21 January 2018

Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M011152200

21 January 2018

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M011152200

21 January 2018

Presenilin is required for activity and nuclear access of Notch in Drosophila

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M011152200

21 January 2018

A common enzyme connects notch signaling and Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M011152200

21 January 2018

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M011152200

21 January 2018

A loss of function mutation of presenilin-2 interferes with amyloid beta-peptide production and notch signaling

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M011152200

21 January 2018

Glycine 384 is required for presenilin-1 function and is conserved in bacterial polytopic aspartyl proteases

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M011152200

21 January 2018

Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M011152200

21 January 2018

Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M011152200

21 January 2018

Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M011152200

21 January 2018

The presenilin 2 mutation (N141I) linked to familial Alzheimer disease (Volga German families) increases the secretion of amyloid beta protein ending at the 42nd (or 43rd) residue

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M011152200

21 January 2018

Evidence for phosphorylation and oligomeric assembly of presenilin 1.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M011152200

21 January 2018

The proteolytic fragments of the Alzheimer's disease-associated presenilin-1 form heterodimers and occur as a 100-150-kDa molecular mass complex

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M011152200

21 January 2018

The presenilin 1 protein is a component of a high molecular weight intracellular complex that contains beta-catenin

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M011152200

21 January 2018

Endoproteolytic processing and stabilization of wild-type and mutant presenilin

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M011152200

21 January 2018

Amyloidogenic function of the Alzheimer's disease-associated presenilin 1 in the absence of endoproteolysis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M011152200

21 January 2018

The influence of endoproteolytic processing of familial Alzheimer's disease presenilin 2 on abeta42 amyloid peptide formation.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M011152200

21 January 2018

Mutational analysis of intrinsic regions of presenilin 2 that determine its endoproteolytic cleavage and pathological function.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M011152200

21 January 2018

Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M011152200

21 January 2018

Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M011152200

21 January 2018

Evidence that levels of presenilins (PS1 and PS2) are coordinately regulated by competition for limiting cellular factors

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M011152200

21 January 2018

Additive effects of PS1 and APP mutations on secretion of the 42-residue amyloid beta-protein.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M011152200

21 January 2018

Molecular dissection of domains in mutant presenilin 2 that mediate overproduction of amyloidogenic forms of amyloid beta peptides. Inability of truncated forms of PS2 with familial Alzheimer's disease mutation to increase secretion of Abeta42.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M011152200

21 January 2018

Expression of Alzheimer's disease-associated presenilin-1 is controlled by proteolytic degradation and complex formation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M011152200

21 January 2018

Pathogenic presenilin 1 mutations (P436S & I143F) in early-onset Alzheimer's disease in the UK. Mutations in brief no. 223. Online.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M011152200

21 January 2018

Two novel presenilin-1 mutations (Ser169Leu and Pro436Gln) associated with very early onset Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M011152200

21 January 2018

Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M011152200

21 January 2018

Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M011152200

21 January 2018

Subunit composition and ATP site labeling of the coated vesicle proton-translocating adenosinetriphosphatase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M011152200

21 January 2018

Presenilin 1 regulates the processing of beta-amyloid precursor protein C-terminal fragments and the generation of amyloid beta-protein in endoplasmic reticulum and Golgi

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M011152200

21 January 2018

Subcellular compartment and molecular subdomain of beta-amyloid precursor protein relevant to the Abeta 42-promoting effects of Alzheimer mutant presenilin 2.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M011152200

21 January 2018

Effects of PS1 deficiency on membrane protein trafficking in neurons

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M011152200

21 January 2018

Requirements for presenilin-dependent cleavage of notch and other transmembrane proteins.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M011152200

21 January 2018

Proteolytic release and nuclear translocation of Notch-1 are induced by presenilin-1 and impaired by pathogenic presenilin-1 mutations

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M011152200

21 January 2018

A loss of function mutant of the presenilin homologue SEL-12 undergoes aberrant endoproteolysis in Caenorhabditis elegans and increases abeta 42 generation in human cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M011152200

21 January 2018

Separation of presenilin function in amyloid beta-peptide generation and endoproteolysis of Notch

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M011152200

21 January 2018

Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M011152200

21 January 2018

Mice lacking both presenilin genes exhibit early embryonic patterning defects

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M011152200

21 January 2018

Mutation of conserved aspartates affects maturation of both aspartate mutant and endogenous presenilin 1 and presenilin 2 complexes

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M011152200

21 January 2018

Primary cultures of neuronal and non-neuronal rat brain cells secrete similar proportions of amyloid β peptides ending at Aβ40 and Aβ42

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M011152200

21 January 2018

Amyloid beta protein (A beta) deposition: A beta 42(43) precedes A beta 40 in Down syndrome

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M011152200

21 January 2018

Presenilins are required for gamma-secretase cleavage of beta-APP and transmembrane cleavage of Notch-1

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M011152200

21 January 2018

Presenilin-1 and -2 are molecular targets for gamma-secretase inhibitors

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M011152200

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M011152200

21 January 2018

Identifiers

10.1074/JBC.M011152200

1 reference

Europe PubMed Central

PubMed publication ID

23 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

23 September 2017

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