(Q53338153)

13 May 2018

title

The influence of endoproteolytic processing of familial Alzheimer's disease presenilin 2 on abeta42 amyloid peptide formation. (English)

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13 May 2018

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Jacobsen H

1

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13 May 2018

Reinhardt D

2

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13 May 2018

Brockhaus M

3

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13 May 2018

Bur D

4

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13 May 2018

Kocyba C

5

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13 May 2018

Kurt H

6

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13 May 2018

Grim MG

7

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13 May 2018

Baumeister R

8

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13 May 2018

Loetscher H

9

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13 May 2018

language of work or name

English

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publication date

1 December 1999

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13 May 2018

Journal of Biological Chemistry

published in

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13 May 2018

volume

274

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13 May 2018

issue

49

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13 May 2018

page(s)

35233-35239

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13 May 2018

A familial Alzheimer's disease locus on chromosome 1.

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Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene

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Presenilins: genes for life and death

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The biological and pathological function of the presenilin-1 Deltaexon 9 mutation is independent of its defect to undergo proteolytic processing

21 January 2018

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Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

21 January 2018

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Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1

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Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo

21 January 2018

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Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice

21 January 2018

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Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

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Phosphorylation, subcellular localization, and membrane orientation of the Alzheimer's disease-associated presenilins.

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Human presenilin-1, but not familial Alzheimer's disease (FAD) mutants, facilitate Caenorhabditis elegans Notch signalling independently of proteolytic processing

21 January 2018

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Assessment of normal and mutant human presenilin function in Caenorhabditis elegans

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Expression of Alzheimer's disease-associated presenilin-1 is controlled by proteolytic degradation and complex formation

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Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo

21 January 2018

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Stable association of presenilin derivatives and absence of presenilin interactions with APP.

21 January 2018

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The proteolytic fragments of the Alzheimer's disease-associated presenilin-1 form heterodimers and occur as a 100-150-kDa molecular mass complex

21 January 2018

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Alternative cleavage of Alzheimer-associated presenilins during apoptosis by a caspase-3 family protease

21 January 2018

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Presenilins are processed by caspase-type proteases.

21 January 2018

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Caspase-mediated cleavage is not required for the activity of presenilins in amyloidogenesis and NOTCH signaling

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Phosphorylation of presenilin-2 regulates its cleavage by caspases and retards progression of apoptosis

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Neurogenic phenotypes and altered Notch processing in Drosophila Presenilin mutants.

21 January 2018

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Presenilin is required for activity and nuclear access of Notch in Drosophila

21 January 2018

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A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

21 January 2018

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Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene

21 January 2018

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Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

21 January 2018

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Proteolysis by presenilins and the renaissance of tau.

21 January 2018

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Endoproteolytic processing and stabilization of wild-type and mutant presenilin

21 January 2018

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Presenilin Proteins Undergo Heterogeneous Endoproteolysis between Thr291and Ala299and Occur as Stable N- and C-Terminal Fragments in Normal and Alzheimer Brain Tissue

21 January 2018

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Evidence That Intramolecular Associations between Presenilin Domains Are Obligatory for Endoproteolytic Processing

21 January 2018

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Protein topology of presenilin 1

21 January 2018

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Subcellular distribution and turnover of presenilins in transfected cells

21 January 2018

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Determination of a cleavage site of presenilin 2 protein in stably transfected SH-SY5Y human neuroblastoma cell lines

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.274.49.35233

1 reference

13 May 2018

1 reference

13 May 2018