(Q41062110)

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The proteolytic fragments of the Alzheimer's disease-associated presenilin-1 form heterodimers and occur as a 100-150-kDa molecular mass complex

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Europe PubMed Central

PubMed publication ID

26 September 2017

The proteolytic fragments of the Alzheimer's disease-associated presenilin-1 form heterodimers and occur as a 100-150-kDa molecular mass complex (English)

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Europe PubMed Central

PubMed publication ID

26 September 2017

Alzheimer's disease

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Christian Haass

9

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Haass C

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26 September 2017

author name string

Capell A

1

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Europe PubMed Central

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26 September 2017

Grünberg J

2

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26 September 2017

Pesold B

3

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Europe PubMed Central

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26 September 2017

Diehlmann A

4

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Europe PubMed Central

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26 September 2017

Citron M

5

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26 September 2017

Nixon R

6

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Europe PubMed Central

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26 September 2017

Beyreuther K

7

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26 September 2017

Selkoe DJ

8

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26 September 2017

language of work or name

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publication date

1 February 1998

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26 September 2017

Journal of Biological Chemistry

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26 September 2017

273

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26 September 2017

6

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26 September 2017

3205-3211

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Europe PubMed Central

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26 September 2017

Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.6.3205

21 January 2018

Human presenilin-1, but not familial Alzheimer's disease (FAD) mutants, facilitate Caenorhabditis elegans Notch signalling independently of proteolytic processing

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.6.3205

21 January 2018

Assessment of normal and mutant human presenilin function in Caenorhabditis elegans

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.6.3205

21 January 2018

Hyperaccumulation of FAD-linked presenilin 1 variants in vivo

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.6.3205

21 January 2018

Amyloid beta-protein and the genetics of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.6.3205

21 January 2018

An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.6.3205

21 January 2018

The E280A presenilin 1 Alzheimer mutation produces increased A beta 42 deposition and severe cerebellar pathology

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.6.3205

21 January 2018

The carboxy terminus of the beta amyloid protein is critical for the seeding of amyloid formation: implications for the pathogenesis of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.6.3205

21 January 2018

Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.6.3205

21 January 2018

Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.6.3205

21 January 2018

Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.6.3205

21 January 2018

Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.6.3205

21 January 2018

The presenilin 2 mutation (N141I) linked to familial Alzheimer disease (Volga German families) increases the secretion of amyloid beta protein ending at the 42nd (or 43rd) residue

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.6.3205

21 January 2018

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.6.3205

21 January 2018

Candidate gene for the chromosome 1 familial Alzheimer's disease locus

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.6.3205

21 January 2018

Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.6.3205

21 January 2018

The Alzheimer family of diseases: many etiologies, one pathogenesis?

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.6.3205

21 January 2018

The gene defects responsible for familial Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.6.3205

21 January 2018

Presenilins: genes for life and death

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.6.3205

21 January 2018

Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.6.3205

21 January 2018

Skeletal and CNS defects in Presenilin-1-deficient mice

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.6.3205

21 January 2018

Presenilin 1 is required for Notch1 and DII1 expression in the paraxial mesoderm

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.6.3205

21 January 2018

Characterization of human presenilin 1 using N-terminal specific monoclonal antibodies: Evidence that Alzheimer mutations affect proteolytic processing

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.6.3205

21 January 2018

Proteolytic processing of the Alzheimer disease-associated presenilin-1 generates an in vivo substrate for protein kinase C.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.6.3205

21 January 2018

Amyloid beta-peptide is produced by cultured cells during normal metabolism

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.6.3205

21 January 2018

Protein interactions regulating vesicle transport between the endoplasmic reticulum and Golgi apparatus in mammalian cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.6.3205

21 January 2018

Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.6.3205

21 January 2018

The Swedish mutation causes early-onset Alzheimer's disease by beta-secretase cleavage within the secretory pathway

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.6.3205

21 January 2018

Evidence for phosphorylation and oligomeric assembly of presenilin 1.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.6.3205

21 January 2018

Presenilins are processed by caspase-type proteases

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.6.3205

21 January 2018

Alternative Cleavage of Alzheimer-Associated Presenilins During Apoptosis by a Caspase-3 Family Protease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.6.3205

21 January 2018

Formation of stable complexes between two Alzheimer's disease gene products: presenilin-2 and beta-amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.6.3205

21 January 2018

Interaction between amyloid precursor protein and presenilins in mammalian cells: implications for the pathogenesis of Alzheimer disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.6.3205

21 January 2018

Presenilin 1 interaction in the brain with a novel member of the Armadillo family

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.6.3205

21 January 2018

Intracellular cleavage of Notch leads to a heterodimeric receptor on the plasma membrane

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.6.3205

21 January 2018

Kuzbanian controls proteolytic processing of Notch and mediates lateral inhibition during Drosophila and vertebrate neurogenesis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.6.3205

21 January 2018

Presenilin Proteins Undergo Heterogeneous Endoproteolysis between Thr291and Ala299and Occur as Stable N- and C-Terminal Fragments in Normal and Alzheimer Brain Tissue

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.6.3205

21 January 2018

Identifiers

10.1074/JBC.273.6.3205

1 reference

Europe PubMed Central

PubMed publication ID

26 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

26 September 2017

ResearchGate publication ID

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