(Q52583319)

4 May 2018

title

Requirements for presenilin-dependent cleavage of notch and other transmembrane proteins. (English)

1 reference

4 May 2018

main subject

transmembrane protein

0 references

Presenilin Dmel_CG18803

1 reference

GOA release 2020-03-11

author name string

Struhl G

series ordinal

1

1 reference

4 May 2018

Adachi A

series ordinal

2

1 reference

4 May 2018

publication date

1 September 2000

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4 May 2018

published in

Molecular Cell

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4 May 2018

volume

6

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4 May 2018

issue

3

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4 May 2018

page(s)

625-636

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4 May 2018

Ligand-independent activation of the sevenless receptor tyrosine kinase changes the fate of cells in the developing Drosophila eye.

cites work

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2900061-7

7 January 2021

Intracellular cleavage of Notch leads to a heterodimeric receptor on the plasma membrane

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2900061-7

7 January 2021

A novel proteolytic cleavage involved in Notch signaling: the role of the disintegrin-metalloprotease TACE

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2900061-7

7 January 2021

The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2900061-7

7 January 2021

Multiple forms of dynamin are encoded by shibire, a Drosophila gene involved in endocytosis.

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2900061-7

7 January 2021

Regulation of the ERBB-2 promoter by RBPJkappa and NOTCH.

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2900061-7

7 January 2021

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2900061-7

7 January 2021

Synergy between suppressor of Hairless and Notch in regulation of Enhancer of split m gamma and m delta expression

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2900061-7

7 January 2021

Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1.

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2900061-7

7 January 2021

Molecular interactions between the protein products of the neurogenic loci Notch and Delta, two EGF-homologous genes in Drosophila

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2900061-7

7 January 2021

GAL4 activates transcription in Drosophila.

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2900061-7

7 January 2021

Transgenic Drosophila expressing human amyloid precursor protein show gamma-secretase activity and a blistered-wing phenotype

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2900061-7

7 January 2021

LIN-12/Notch signaling: lessons from worms and flies

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2900061-7

7 January 2021

Analysis of gain-of-function mutations of the lin-12 gene of Caenorhabditis elegans.

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2900061-7

7 January 2021

Total inactivation of gamma-secretase activity in presenilin-deficient embryonic stem cells.

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2900061-7

7 January 2021

Embryonic lethality in mice homozygous for a processing-deficient allele of Notch1.

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2900061-7

7 January 2021

Identification of a Novel Aspartic Protease (Asp 2) as β-Secretase

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2900061-7

7 January 2021

Signalling downstream of activated mammalian Notch

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2900061-7

7 January 2021

Molecular cloning of the CD3 eta subunit identifies a CD3 zeta-related product in thymus-derived cells

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2900061-7

7 January 2021

Presenilin-1 mutations downregulate the signalling pathway of the unfolded-protein response

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2900061-7

7 January 2021

Ligand-induced cleavage and regulation of nuclear entry of Notch in Drosophila melanogaster embryos

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2900061-7

7 January 2021

Indirect evidence for Delta-dependent intracellular processing of notch in Drosophila embryos

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2900061-7

7 January 2021

Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2900061-7

7 January 2021

Notch signalling and the control of cell fate choices in vertebrates.

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2900061-7

7 January 2021

HOP-1, a Caenorhabditis elegans presenilin, appears to be functionally redundant with SEL-12 presenilin and to facilitate LIN-12 and GLP-1 signaling

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2900061-7

7 January 2021

Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2900061-7

7 January 2021

Antineurogenic phenotypes induced by truncated Notch proteins indicate a role in signal transduction and may point to a novel function for Notch in nuclei

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2900061-7

7 January 2021

The Notch1 receptor is cleaved constitutively by a furin-like convertase

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2900061-7

7 January 2021

A ligand-induced extracellular cleavage regulates gamma-secretase-like proteolytic activation of Notch1

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2900061-7

7 January 2021

gamma-Secretase, evidence for multiple proteolytic activities and influence of membrane positioning of substrate on generation of amyloid beta peptides of varying length

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2900061-7

7 January 2021

A role for presenilin-1 in nuclear accumulation of Ire1 fragments and induction of the mammalian unfolded protein response

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2900061-7

7 January 2021

Kuzbanian controls proteolytic processing of Notch and mediates lateral inhibition during Drosophila and vertebrate neurogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2900061-7

7 January 2021

shibire, a neurogenic mutant of Drosophila.

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2900061-7

7 January 2021

Processing of the notch ligand delta by the metalloprotease Kuzbanian

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2900061-7

7 January 2021

Calcium depletion dissociates and activates heterodimeric notch receptors

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2900061-7

7 January 2021

Evidence for a physical interaction between presenilin and Notch

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2900061-7

7 January 2021

Specific truncations of Drosophila Notch define dominant activated and dominant negative forms of the receptor.

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2900061-7

7 January 2021

KUZ, a conserved metalloprotease-disintegrin protein with two roles in Drosophila neurogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2900061-7

7 January 2021

TOXCAT: a measure of transmembrane helix association in a biological membrane

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2900061-7

7 January 2021

GAL4-VP16 is an unusually potent transcriptional activator

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2900061-7

7 January 2021

Temperature-sensitive periods and autonomy of pleiotropic effects of l(1)Nts1, a conditional notch lethal in Drosophila

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2900061-7

7 January 2021

Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2900061-7

7 January 2021

The cell biology of beta-amyloid precursor protein and presenilin in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2900061-7

7 January 2021

Requirement for dynamin during Notch signaling in Drosophila neurogenesis.

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2900061-7

7 January 2021

Skeletal and CNS defects in Presenilin-1-deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2900061-7

7 January 2021

Purification and cloning of amyloid precursor protein beta-secretase from human brain

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2900061-7

7 January 2021

Proteolytic release and nuclear translocation of Notch-1 are induced by presenilin-1 and impaired by pathogenic presenilin-1 mutations

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2900061-7

7 January 2021

Intrinsic activity of the Lin-12 and Notch intracellular domains in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2900061-7

7 January 2021

Nuclear access and action of notch in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2900061-7

7 January 2021

Presenilin is required for activity and nuclear access of Notch in Drosophila

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2900061-7

7 January 2021

Dynamin-like protein encoded by the Drosophila shibire gene associated with vesicular traffic

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2900061-7

7 January 2021

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2900061-7

7 January 2021

Reverse genetic analysis of Caenorhabditis elegans presenilins reveals redundant but unequal roles for sel-12 and hop-1 in Notch-pathway signaling

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2900061-7

7 January 2021

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2900061-7

7 January 2021

Presenilin 1 is required for Notch1 and DII1 expression in the paraxial mesoderm

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2900061-7

7 January 2021

Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2900061-7

7 January 2021

Neurogenic phenotypes and altered Notch processing in Drosophila Presenilin mutants.

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2900061-7

7 January 2021

Presenilins are required for gamma-secretase cleavage of beta-APP and transmembrane cleavage of Notch-1

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2900061-7

7 January 2021

10.1016/S1097-2765(00)00061-7

Identifiers

DOI

1 reference

4 May 2018

1 reference

4 May 2018