(Q77336168)

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gamma-Secretase, evidence for multiple proteolytic activities and influence of membrane positioning of substrate on generation of amyloid beta peptides of varying length

scientific article published on 01 April 1999

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10207012%20AND%20SRC:MED&resulttype=core&format=json

4 December 2019

gamma-Secretase, evidence for multiple proteolytic activities and influence of membrane positioning of substrate on generation of amyloid beta peptides of varying length (English)

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10207012%20AND%20SRC:MED&resulttype=core&format=json

4 December 2019

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M P Murphy

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10207012%20AND%20SRC:MED&resulttype=core&format=json

4 December 2019

L J Hickman

2

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10207012%20AND%20SRC:MED&resulttype=core&format=json

4 December 2019

C B Eckman

3

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10207012%20AND%20SRC:MED&resulttype=core&format=json

4 December 2019

S N Uljon

4

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4 December 2019

R Wang

5

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4 December 2019

T E Golde

6

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4 December 2019

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1 April 1999

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4 December 2019

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10

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Journal of Biological Chemistry

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4 December 2019

274

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4 December 2019

17

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4 December 2019

11914-11923

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10207012%20AND%20SRC:MED&resulttype=core&format=json

4 December 2019

Amyloid beta-peptide is produced by cultured cells during normal metabolism

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.17.11914

21 January 2018

Production of the Alzheimer amyloid beta protein by normal proteolytic processing

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.17.11914

21 January 2018

Generation of beta-amyloid in the secretory pathway in neuronal and nonneuronal cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.17.11914

21 January 2018

The profile of soluble amyloid beta protein in cultured cell media. Detection and quantification of amyloid beta protein and variants by immunoprecipitation-mass spectrometry

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.17.11914

21 January 2018

An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.17.11914

21 January 2018

Isolation and quantification of soluble Alzheimer's beta-peptide from biological fluids

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.17.11914

21 January 2018

Amyloid, the presenilins and Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.17.11914

21 January 2018

Mutant genes in familial Alzheimer's disease and transgenic models

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.17.11914

21 January 2018

Amyloid beta protein (A beta) in Alzheimer's disease brain. Biochemical and immunocytochemical analysis with antibodies specific for forms ending at A beta 40 or A beta 42(43).

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.17.11914

21 January 2018

Visualization of A beta 42(43) and A beta 40 in senile plaques with end-specific A beta monoclonals: evidence that an initially deposited species is A beta 42(43).

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.17.11914

21 January 2018

The C-terminus of the beta protein is critical in amyloidogenesis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.17.11914

21 January 2018

Identification, biogenesis, and localization of precursors of Alzheimer's disease A4 amyloid protein.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.17.11914

21 January 2018

Cleavage of amyloid beta peptide during constitutive processing of its precursor

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.17.11914

21 January 2018

Evidence that beta-amyloid protein in Alzheimer's disease is not derived by normal processing

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.17.11914

21 January 2018

Generation of amyloid β protein from its precursor is sequence specific

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.17.11914

21 January 2018

Beta-amyloid precursor protein. Location of transmembrane domain and specificity of gamma-secretase cleavage

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.17.11914

21 January 2018

Mutations in the transmembrane domain of APP altering gamma-secretase specificity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.17.11914

21 January 2018

The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.17.11914

21 January 2018

Sterol-regulated release of SREBP-2 from cell membranes requires two sequential cleavages, one within a transmembrane segment

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.17.11914

21 January 2018

Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.17.11914

21 January 2018

Second-site cleavage in sterol regulatory element-binding protein occurs at transmembrane junction as determined by cysteine panning

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.17.11914

21 January 2018

Release of excess amyloid beta protein from a mutant amyloid beta protein precursor.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.17.11914

21 January 2018

Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.17.11914

21 January 2018

Reversal of the Swedish familial Alzheimer's disease mutant phenotype in cultured cells treated with phorbol 12,13-dibutyrate

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.17.11914

21 January 2018

Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.17.11914

21 January 2018

Cholinergic agonists and interleukin 1 regulate processing and secretion of the Alzheimer beta/A4 amyloid protein precursor

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.17.11914

21 January 2018

Potentially Amyloidogenic, Carboxyl-Terminal Derivatives of the Amyloid Protein Precursor

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.17.11914

21 January 2018

Processing of the Amyloid Protein Precursor to Potentially Amyloidogenic Derivatives

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.17.11914

21 January 2018

Amyloid precursor protein truncated at any of the gamma-secretase sites is not cleaved to beta-amyloid

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.17.11914

21 January 2018

The triplet of lysine residues (Lys724-Lys725-Lys726) of Alzheimer's amyloid precursor protein plays an important role in membrane anchorage and processing

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.17.11914

21 January 2018

Macrophage protein turnover. Evidence for lysosomal participation in basal proteolysis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.17.11914

21 January 2018

A new pathogenic mutation in the APP gene (I716V) increases the relative proportion of A beta 42(43)

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.17.11914

21 January 2018

Evidence that the 42- and 40-amino acid forms of amyloid beta protein are generated from the beta-amyloid precursor protein by different protease activities

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.17.11914

21 January 2018

Inhibition of β-amyloid formation identifies proteolytic precursors and subcellular site of catabolism

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.17.11914

21 January 2018

Calpain inhibitor I decreases beta A4 secretion from human embryonal kidney cells expressing beta-amyloid precursor protein carrying the APP670/671 double mutation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.17.11914

21 January 2018

The carboxyl termini of beta-amyloid peptides 1-40 and 1-42 are generated by distinct gamma-secretase activities

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.17.11914

21 January 2018

A substrate-based difluoro ketone selectively inhibits Alzheimer's gamma-secretase activity.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.17.11914

21 January 2018

Intracellular generation and accumulation of amyloid beta-peptide terminating at amino acid 42.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.17.11914

21 January 2018

Alzheimer's A beta(1-42) is generated in the endoplasmic reticulum/intermediate compartment of NT2N cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.17.11914

21 January 2018

Distinct sites of intracellular production for Alzheimer's disease A beta40/42 amyloid peptides.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.17.11914

21 January 2018

Enzyme-substrate interactions in the hydrolysis of peptide substrates by thermitase, subtilisin BPN', and proteinase K

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.17.11914

21 January 2018

A microtiter plate assay for the characterization of serine proteases by their esterase activity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.17.11914

21 January 2018

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.17.11914

21 January 2018

Membrane protein secretases

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.17.11914

21 January 2018

Identifiers

10.1074/JBC.274.17.11914

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10207012%20AND%20SRC:MED&resulttype=core&format=json

4 December 2019

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10207012%20AND%20SRC:MED&resulttype=core&format=json

4 December 2019

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