(Q53341825)

English

Total inactivation of gamma-secretase activity in presenilin-deficient embryonic stem cells.

scientific article published in July 2000

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

13 May 2018

http://europepmc.org/abstract/MED/10878813

Total inactivation of gamma-secretase activity in presenilin-deficient embryonic stem cells. (English)

1 reference

Europe PubMed Central

PubMed publication ID

13 May 2018

http://europepmc.org/abstract/MED/10878813

author name string

Herreman A

1

1 reference

Europe PubMed Central

PubMed publication ID

13 May 2018

http://europepmc.org/abstract/MED/10878813

Serneels L

2

1 reference

Europe PubMed Central

PubMed publication ID

13 May 2018

http://europepmc.org/abstract/MED/10878813

Annaert W

3

1 reference

Europe PubMed Central

PubMed publication ID

13 May 2018

http://europepmc.org/abstract/MED/10878813

Collen D

4

1 reference

Europe PubMed Central

PubMed publication ID

13 May 2018

http://europepmc.org/abstract/MED/10878813

Schoonjans L

5

1 reference

Europe PubMed Central

PubMed publication ID

13 May 2018

http://europepmc.org/abstract/MED/10878813

De Strooper B

6

1 reference

Europe PubMed Central

PubMed publication ID

13 May 2018

http://europepmc.org/abstract/MED/10878813

publication date

1 July 2000

1 reference

Europe PubMed Central

PubMed publication ID

13 May 2018

http://europepmc.org/abstract/MED/10878813

Nature Cell Biology

1 reference

Europe PubMed Central

PubMed publication ID

13 May 2018

http://europepmc.org/abstract/MED/10878813

2

1 reference

Europe PubMed Central

PubMed publication ID

13 May 2018

http://europepmc.org/abstract/MED/10878813

7

1 reference

Europe PubMed Central

PubMed publication ID

13 May 2018

http://europepmc.org/abstract/MED/10878813

461-462

1 reference

Europe PubMed Central

PubMed publication ID

13 May 2018

http://europepmc.org/abstract/MED/10878813

https://scigraph.springernature.com/pub.10.1038/35017105

0 references

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1038%2F35017105

7 January 2021

based on heuristic

inferred from DOI database lookup

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

1 reference

https://api.crossref.org/works/10.1038%2F35017105

7 January 2021

based on heuristic

inferred from DOI database lookup

The presenilins in Alzheimer's disease--proteolysis holds the key.

1 reference

https://api.crossref.org/works/10.1038%2F35017105

7 January 2021

based on heuristic

inferred from DOI database lookup

Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency

1 reference

https://api.crossref.org/works/10.1038%2F35017105

7 January 2021

based on heuristic

inferred from DOI database lookup

Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production

1 reference

https://api.crossref.org/works/10.1038%2F35017105

7 January 2021

based on heuristic

inferred from DOI database lookup

Release of excess amyloid beta protein from a mutant amyloid beta protein precursor.

1 reference

https://api.crossref.org/works/10.1038%2F35017105

7 January 2021

based on heuristic

inferred from DOI database lookup

Proteolytic release and nuclear translocation of Notch-1 are induced by presenilin-1 and impaired by pathogenic presenilin-1 mutations

1 reference

https://api.crossref.org/works/10.1038%2F35017105

7 January 2021

based on heuristic

inferred from DOI database lookup

Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain

1 reference

https://api.crossref.org/works/10.1038%2F35017105

7 January 2021

based on heuristic

inferred from DOI database lookup

Signalling downstream of activated mammalian Notch

1 reference

https://api.crossref.org/works/10.1038%2F35017105

7 January 2021

based on heuristic

inferred from DOI database lookup

Mice lacking both presenilin genes exhibit early embryonic patterning defects

1 reference

https://api.crossref.org/works/10.1038%2F35017105

7 January 2021

based on heuristic

inferred from DOI database lookup

The transmembrane aspartates in presenilin 1 and 2 are obligatory for gamma-secretase activity and amyloid beta-protein generation

1 reference

https://api.crossref.org/works/10.1038%2F35017105

7 January 2021

based on heuristic

inferred from DOI database lookup

A loss of function mutation of presenilin-2 interferes with amyloid beta-peptide production and notch signaling

1 reference

https://api.crossref.org/works/10.1038%2F35017105

7 January 2021

based on heuristic

inferred from DOI database lookup

Regulated intramembrane proteolysis: a control mechanism conserved from bacteria to humans

1 reference

https://api.crossref.org/works/10.1038%2F35017105

7 January 2021

based on heuristic

inferred from DOI database lookup

Presenilin 1 controls gamma-secretase processing of amyloid precursor protein in pre-golgi compartments of hippocampal neurons

1 reference

https://api.crossref.org/works/10.1038%2F35017105

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1038/35017105

1 reference

Europe PubMed Central

PubMed publication ID

13 May 2018

http://europepmc.org/abstract/MED/10878813

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

13 May 2018

http://europepmc.org/abstract/MED/10878813

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