(Q73949956)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10878814%20AND%20SRC:MED&resulttype=core&format=json

8 November 2019

title

Presenilins are required for gamma-secretase cleavage of beta-APP and transmembrane cleavage of Notch-1 (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10878814%20AND%20SRC:MED&resulttype=core&format=json

8 November 2019

author name string

Zhang Z

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10878814%20AND%20SRC:MED&resulttype=core&format=json

8 November 2019

Nadeau P

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10878814%20AND%20SRC:MED&resulttype=core&format=json

8 November 2019

Song W

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10878814%20AND%20SRC:MED&resulttype=core&format=json

8 November 2019

Donoviel D

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10878814%20AND%20SRC:MED&resulttype=core&format=json

8 November 2019

Yuan M

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10878814%20AND%20SRC:MED&resulttype=core&format=json

8 November 2019

Bernstein A

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10878814%20AND%20SRC:MED&resulttype=core&format=json

8 November 2019

Yankner BA

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10878814%20AND%20SRC:MED&resulttype=core&format=json

8 November 2019

publication date

1 July 2000

1 reference

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8 November 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10878814%20AND%20SRC:MED&resulttype=core&format=json

8 November 2019

volume

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10878814%20AND%20SRC:MED&resulttype=core&format=json

8 November 2019

page(s)

463-465

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10878814%20AND%20SRC:MED&resulttype=core&format=json

8 November 2019

issue

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10878814%20AND%20SRC:MED&resulttype=core&format=json

https://scigraph.springernature.com/pub.10.1038/35017108

8 November 2019

exact match

0 references

cites work

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

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7 January 2021

Candidate gene for the chromosome 1 familial Alzheimer's disease locus

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7 January 2021

Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

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A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

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Effects of PS1 deficiency on membrane protein trafficking in neurons.

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7 January 2021

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

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7 January 2021

A loss of function mutation of presenilin-2 interferes with amyloid beta-peptide production and notch signaling

1 reference

7 January 2021

The transmembrane aspartates in presenilin 1 and 2 are obligatory for gamma-secretase activity and amyloid beta-protein generation

1 reference

7 January 2021

Proteolytic release and nuclear translocation of Notch-1 are induced by presenilin-1 and impaired by pathogenic presenilin-1 mutations

1 reference

7 January 2021

Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene

1 reference

7 January 2021

Skeletal and CNS defects in Presenilin-1-deficient mice

1 reference

7 January 2021

Presenilin 1 is required for Notch1 and DII1 expression in the paraxial mesoderm

1 reference

7 January 2021

Presenilin is required for activity and nuclear access of Notch in Drosophila

1 reference

7 January 2021

Neurogenic phenotypes and altered Notch processing in Drosophila Presenilin mutants.

1 reference

7 January 2021

Mice lacking both presenilin genes exhibit early embryonic patterning defects

1 reference

7 January 2021

Electrophoretic Separation of βA4 Peptides (1–40) and (1–42)

1 reference

7 January 2021

Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain

1 reference

7 January 2021

Mechanisms of neuronal degeneration in Alzheimer's disease

1 reference

7 January 2021

Generation of beta-amyloid in the secretory pathway in neuronal and nonneuronal cells

1 reference

7 January 2021