(Q41018706)

English

Molecular dissection of domains in mutant presenilin 2 that mediate overproduction of amyloidogenic forms of amyloid beta peptides. Inability of truncated forms of PS2 with familial Alzheimer's disease mutation to increase secretion of Abeta42.

scientific article published on August 1998

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scholarly article

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Europe PubMed Central

PubMed publication ID

25 September 2017

Molecular dissection of domains in mutant presenilin 2 that mediate overproduction of amyloidogenic forms of amyloid beta peptides. Inability of truncated forms of PS2 with familial Alzheimer's disease mutation to increase secretion of Abeta42. (English)

1 reference

Europe PubMed Central

PubMed publication ID

25 September 2017

Alzheimer's disease

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1

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PubMed publication ID

25 September 2017

author name string

Tokuhiro S

2

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Europe PubMed Central

PubMed publication ID

25 September 2017

Hashimoto T

3

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Europe PubMed Central

PubMed publication ID

25 September 2017

Aiba K

4

1 reference

Europe PubMed Central

PubMed publication ID

25 September 2017

Saido TC

5

1 reference

Europe PubMed Central

PubMed publication ID

25 September 2017

Maruyama K

6

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Europe PubMed Central

PubMed publication ID

25 September 2017

Iwatsubo T

7

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Europe PubMed Central

PubMed publication ID

25 September 2017

language of work or name

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publication date

1 August 1998

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Europe PubMed Central

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25 September 2017

Journal of Biological Chemistry

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Europe PubMed Central

PubMed publication ID

25 September 2017

273

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Europe PubMed Central

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25 September 2017

33

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Europe PubMed Central

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25 September 2017

21153-21160

1 reference

Europe PubMed Central

PubMed publication ID

25 September 2017

Normal and abnormal biology of the beta-amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.33.21153

21 January 2018

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.33.21153

21 January 2018

Candidate gene for the chromosome 1 familial Alzheimer's disease locus

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.33.21153

21 January 2018

Alzheimer-associated presenilins 1 and 2: neuronal expression in brain and localization to intracellular membranes in mammalian cells.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.33.21153

21 January 2018

Expression and analysis of presenilin 1 in a human neuronal system: localization in cell bodies and dendrites

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.33.21153

21 January 2018

The Alzheimer family of diseases: many etiologies, one pathogenesis?

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.33.21153

21 January 2018

Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.33.21153

21 January 2018

Assessment of normal and mutant human presenilin function in Caenorhabditis elegans

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.33.21153

21 January 2018

Human presenilin-1, but not familial Alzheimer's disease (FAD) mutants, facilitate Caenorhabditis elegans Notch signalling independently of proteolytic processing

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.33.21153

21 January 2018

Presenilin 1 is required for Notch1 and DII1 expression in the paraxial mesoderm

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.33.21153

21 January 2018

Skeletal and CNS defects in Presenilin-1-deficient mice

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.33.21153

21 January 2018

Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.33.21153

21 January 2018

Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.33.21153

21 January 2018

Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.33.21153

21 January 2018

The presenilin 2 mutation (N141I) linked to familial Alzheimer disease (Volga German families) increases the secretion of amyloid beta protein ending at the 42nd (or 43rd) residue

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.33.21153

21 January 2018

The carboxy terminus of the beta amyloid protein is critical for the seeding of amyloid formation: implications for the pathogenesis of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.33.21153

21 January 2018

An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.33.21153

21 January 2018

Visualization of A beta 42(43) and A beta 40 in senile plaques with end-specific A beta monoclonals: evidence that an initially deposited species is A beta 42(43).

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.33.21153

21 January 2018

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.33.21153

21 January 2018

Formation of stable complexes between two Alzheimer's disease gene products: presenilin-2 and beta-amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.33.21153

21 January 2018

Interaction between amyloid precursor protein and presenilins in mammalian cells: implications for the pathogenesis of Alzheimer disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.33.21153

21 January 2018

Stable association of presenilin derivatives and absence of presenilin interactions with APP.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.33.21153

21 January 2018

Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.33.21153

21 January 2018

Evidence that levels of presenilins (PS1 and PS2) are coordinately regulated by competition for limiting cellular factors.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.33.21153

21 January 2018

Alternative cleavage of Alzheimer-associated presenilins during apoptosis by a caspase-3 family protease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.33.21153

21 January 2018

Early-onset Alzheimer's disease with a presenilin-1 mutation at the site corresponding to the Volga German presenilin-2 mutation.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.33.21153

21 January 2018

Amino acid preferences for specific locations at the ends of alpha helices

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.33.21153

21 January 2018

Two novel (M233T and R278T) presenilin-1 mutations in early-onset Alzheimer's disease pedigrees and preliminary evidence for association of presenilin-1 mutations with a novel phenotype.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.33.21153

21 January 2018

Amyloid (Abeta) deposition in chromosome 1-linked Alzheimer's disease: the Volga German families.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.33.21153

21 January 2018

Increased apoptosis arising from increased expression of the Alzheimer's disease-associated presenilin-2 mutation (N141I).

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.33.21153

21 January 2018

Evidence for phosphorylation and oligomeric assembly of presenilin 1.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.33.21153

21 January 2018

The proteolytic fragments of the Alzheimer's disease-associated presenilin-1 form heterodimers and occur as a 100-150-kDa molecular mass complex

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.33.21153

21 January 2018

Endoproteolytic processing and stabilization of wild-type and mutant presenilin

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.33.21153

21 January 2018

Presenilin Proteins Undergo Heterogeneous Endoproteolysis between Thr291and Ala299and Occur as Stable N- and C-Terminal Fragments in Normal and Alzheimer Brain Tissue

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.33.21153

21 January 2018

Identifiers

10.1074/JBC.273.33.21153

1 reference

Europe PubMed Central

PubMed publication ID

25 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

25 September 2017

ResearchGate publication ID

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