(Q40845419)

24 September 2017

title

Glycine 384 is required for presenilin-1 function and is conserved in bacterial polytopic aspartyl proteases (English)

1 reference

24 September 2017

12

Haass C

1 reference

24 September 2017

Steiner H

1

1 reference

24 September 2017

Kostka M

2

1 reference

24 September 2017

Romig H

3

1 reference

24 September 2017

Basset G

4

1 reference

24 September 2017

Pesold B

5

1 reference

24 September 2017

Hardy J

6

1 reference

24 September 2017

Capell A

7

1 reference

24 September 2017

Meyn L

8

1 reference

24 September 2017

Grim ML

9

1 reference

24 September 2017

Baumeister R

10

1 reference

24 September 2017

Fechteler K

11

1 reference

24 September 2017

publication date

1 November 2000

1 reference

24 September 2017

1 reference

24 September 2017

volume

2

1 reference

24 September 2017

issue

11

1 reference

24 September 2017

page(s)

848-851

1 reference

Translating cell biology into therapeutic advances in Alzheimer's disease

24 September 2017

cites work

1 reference

7 January 2021

Regulated intramembrane proteolysis: a control mechanism conserved from bacteria to humans

1 reference

7 January 2021

The presenilins in Alzheimer's disease--proteolysis holds the key.

1 reference

7 January 2021

A role for presenilin-1 in nuclear accumulation of Ire1 fragments and induction of the mammalian unfolded protein response

1 reference

7 January 2021

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

1 reference

7 January 2021

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

1 reference

7 January 2021

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

1 reference

7 January 2021

A loss of function mutation of presenilin-2 interferes with amyloid beta-peptide production and notch signaling

1 reference

7 January 2021

The transmembrane aspartates in presenilin 1 and 2 are obligatory for gamma-secretase activity and amyloid beta-protein generation

1 reference

7 January 2021

Cell surface presenilin-1 participates in the gamma-secretase-like proteolysis of Notch

1 reference

7 January 2021

Presenilin-1 differentially facilitates endoproteolysis of the beta-amyloid precursor protein and Notch

1 reference

7 January 2021

Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1

1 reference

7 January 2021

Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1.

1 reference

7 January 2021

Alzheimer's disease. Closing in on gamma-secretase.

1 reference

7 January 2021

Molecular genetic analysis of familial early-onset Alzheimer's disease linked to chromosome 14q24.3.

1 reference

7 January 2021

Evidence that Abeta42 plasma levels in presenilin-1 mutation carriers do not allow for prediction of their clinical phenotype

1 reference

7 January 2021

Evidence that levels of presenilins (PS1 and PS2) are coordinately regulated by competition for limiting cellular factors

1 reference

7 January 2021

Amyloidogenic function of the Alzheimer's disease-associated presenilin 1 in the absence of endoproteolysis

1 reference

7 January 2021

Enhancement of amyloid beta 42 secretion by 28 different presenilin 1 mutations of familial Alzheimer's disease

1 reference

7 January 2021

The biological and pathological function of the presenilin-1 Deltaexon 9 mutation is independent of its defect to undergo proteolytic processing

1 reference

7 January 2021

Proteolytic release and nuclear translocation of Notch-1 are induced by presenilin-1 and impaired by pathogenic presenilin-1 mutations

1 reference

7 January 2021

Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain

1 reference

7 January 2021

Separation of presenilin function in amyloid beta-peptide generation and endoproteolysis of Notch

1 reference

7 January 2021

Embryonic lethality in mice homozygous for a processing-deficient allele of Notch1.

1 reference

7 January 2021

The type 4 prepilin peptidases comprise a novel family of aspartic acid proteases

1 reference

7 January 2021

Protein topology of presenilin 1

1 reference

7 January 2021

Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production

1 reference

7 January 2021

Intracellular generation and accumulation of amyloid beta-peptide terminating at amino acid 42.

1 reference

7 January 2021

Improved electrophoretic separation and immunoblotting of beta-amyloid (A beta) peptides 1-40, 1-42, and 1-43.

1 reference

7 January 2021

Expression of Alzheimer's disease-associated presenilin-1 is controlled by proteolytic degradation and complex formation

1 reference

7 January 2021

Identifiers

DOI

10.1038/35041097

1 reference

Dimensions Publication ID

24 September 2017

1045210161

0 references

1 reference