(Q33678168)

28 July 2017

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title

Translating cell biology into therapeutic advances in Alzheimer's disease (English)

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28 July 2017

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Selkoe DJ

1

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PubMed ID

10392577

28 July 2017

language of work or name

English

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publication date

1 June 1999

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28 July 2017

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28 July 2017

399

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28 July 2017

A23-31

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28 July 2017

6738 Suppl

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https://scigraph.springernature.com/pub.10.1038/399a023

28 July 2017

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cites work

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7 January 2021

Association of apolipoprotein E allele epsilon 4 with late-onset familial and sporadic Alzheimer's disease

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7 January 2021

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

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7 January 2021

Candidate gene for the chromosome 1 familial Alzheimer's disease locus

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7 January 2021

Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene

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7 January 2021

Alpha-2 macroglobulin is genetically associated with Alzheimer disease.

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7 January 2021

Mutation in the tau gene in familial multiple system tauopathy with presenile dementia

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7 January 2021

Association of missense and 5'-splice-site mutations in tau with the inherited dementia FTDP-17

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7 January 2021

Tau is a candidate gene for chromosome 17 frontotemporal dementia

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Tau mutations cause frontotemporal dementias.

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7 January 2021

The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

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7 January 2021

Alzheimer's disease and Down's syndrome: Sharing of a unique cerebrovascular amyloid fibril protein

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7 January 2021

Cell biology of the amyloid beta-protein precursor and the mechanism of Alzheimer's disease

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7 January 2021

beta-Amyloid precursor protein-deficient mice show reactive gliosis and decreased locomotor activity

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7 January 2021

The beta-amyloid precursor protein of Alzheimer's disease enhances neuron viability and modulates neuronal polarity

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7 January 2021

Identification of a mouse brain cDNA that encodes a protein related to the Alzheimer disease-associated amyloid beta protein precursor

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7 January 2021

Beta-amyloid precursor protein cleavage by a membrane-bound protease

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7 January 2021

A metalloproteinase disintegrin that releases tumour-necrosis factor-alpha from cells

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7 January 2021

Evidence that tumor necrosis factor alpha converting enzyme is involved in regulated alpha-secretase cleavage of the Alzheimer amyloid protein precursor

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7 January 2021

Amyloid beta-peptide is produced by cultured cells during normal metabolism

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7 January 2021

Production of the Alzheimer amyloid beta protein by normal proteolytic processing

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7 January 2021

Isolation and quantification of soluble Alzheimer's beta-peptide from biological fluids

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Generation of beta-amyloid in the secretory pathway in neuronal and nonneuronal cells

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7 January 2021

Secretion of beta-amyloid precursor protein cleaved at the amino terminus of the beta-amyloid peptide

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7 January 2021

Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene

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7 January 2021

Assessment of normal and mutant human presenilin function in Caenorhabditis elegans

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Human presenilin-1, but not familial Alzheimer's disease (FAD) mutants, facilitate Caenorhabditis elegans Notch signalling independently of proteolytic processing.

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Presenilin 1 interaction in the brain with a novel member of the Armadillo family

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The presenilin 1 protein is a component of a high molecular weight intracellular complex that contains beta-catenin

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Presenilin 1 is required for Notch1 and DII1 expression in the paraxial mesoderm

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7 January 2021

Skeletal and CNS defects in Presenilin-1-deficient mice

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7 January 2021

Mutant human presenilin 1 protects presenilin 1 null mouse against embryonic lethality and elevates Abeta1-42/43 expression.

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7 January 2021

Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo

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7 January 2021

Presenilin Proteins Undergo Heterogeneous Endoproteolysis between Thr291and Ala299and Occur as Stable N- and C-Terminal Fragments in Normal and Alzheimer Brain Tissue

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7 January 2021

Additional evidence for an eight-transmembrane-domain topology for Caenorhabditis elegans and human presenilins

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7 January 2021

Evidence that levels of presenilins (PS1 and PS2) are coordinately regulated by competition for limiting cellular factors.

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7 January 2021

Expression of Alzheimer's disease-associated presenilin-1 is controlled by proteolytic degradation and complex formation

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7 January 2021

The proteolytic fragments of the Alzheimer's disease-associated presenilin-1 form heterodimers and occur as a 100-150-kDa molecular mass complex

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7 January 2021

Subcellular distribution and turnover of presenilins in transfected cells

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7 January 2021

Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

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7 January 2021

Molecular dissection of domains in mutant presenilin 2 that mediate overproduction of amyloidogenic forms of amyloid beta peptides. Inability of truncated forms of PS2 with familial Alzheimer's disease mutation to increase secretion of Abeta42.

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Alzheimer's disease: genotypes, phenotypes, and treatments

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Sequence of deposition of heterogeneous amyloid beta-peptides and APO E in Down syndrome: implications for initial events in amyloid plaque formation.

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Microglial cells and amyloid beta protein (A beta) deposition; association with A beta 40-containing plaques

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Mutation of the Alzheimer's disease amyloid gene in hereditary cerebral hemorrhage, Dutch type.

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Presenile dementia and cerebral haemorrhage linked to a mutation at codon 692 of the beta-amyloid precursor protein gene.

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7 January 2021

Co-expression of beta-amyloid precursor protein (betaAPP) and apolipoprotein E in cell culture: analysis of betaAPP processing

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7 January 2021

Increased amyloid beta-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer disease

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7 January 2021

Apolipoprotein E in sporadic Alzheimer's disease: allelic variation and receptor interactions

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7 January 2021

Amyloid-associated proteins α1-antichymotrypsin and apolipoprotein E promote assembly of Alzheimer β-protein into filaments

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7 January 2021

Apolipoprotein E is a kinetic but not a thermodynamic inhibitor of amyloid formation: implications for the pathogenesis and treatment of Alzheimer disease

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7 January 2021

Lack of apolipoprotein E dramatically reduces amyloid beta-peptide deposition.

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7 January 2021

The Alzheimer family of diseases: many etiologies, one pathogenesis?

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7 January 2021

Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes

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7 January 2021

The E280A presenilin 1 Alzheimer mutation produces increased A beta 42 deposition and severe cerebellar pathology.

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7 January 2021

Amyloid beta protein (Abeta) deposition in chromosome 14-linked Alzheimer's disease: predominance of Abeta42(43).

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7 January 2021

Stable association of presenilin derivatives and absence of presenilin interactions with APP.

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7 January 2021

Presenilin 1 regulates the processing of beta-amyloid precursor protein C-terminal fragments and the generation of amyloid beta-protein in endoplasmic reticulum and Golgi.

1 reference

7 January 2021

Formation of stable complexes between two Alzheimer's disease gene products: presenilin-2 and beta-amyloid precursor protein

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7 January 2021

Interaction between amyloid precursor protein and presenilins in mammalian cells: implications for the pathogenesis of Alzheimer disease

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7 January 2021

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

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7 January 2021

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

1 reference

7 January 2021

Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain

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7 January 2021

Caspase-mediated cleavage is not required for the activity of presenilins in amyloidogenesis and NOTCH signaling.

1 reference

7 January 2021

Detection of a novel intraneuronal pool of insoluble amyloid beta protein that accumulates with time in culture

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7 January 2021

Inflammatory mechanisms in Alzheimer's disease.

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7 January 2021

The inflammatory response system of brain: implications for therapy of Alzheimer and other neurodegenerative diseases

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7 January 2021

Inflammation and Alzheimer's disease pathogenesis

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7 January 2021

Complement activation by beta-amyloid in Alzheimer disease

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7 January 2021

Ultrastructural localization of complement membrane attack complex (MAC)-like immunoreactivity in brains of patients with Alzheimer's disease.

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7 January 2021

Hydrogen peroxide mediates amyloid beta protein toxicity

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7 January 2021

Direct evidence of oxidative injury produced by the Alzheimer's beta-amyloid peptide (1-40) in cultured hippocampal neurons

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7 January 2021

A controlled trial of selegiline, alpha-tocopherol, or both as treatment for Alzheimer's disease. The Alzheimer's Disease Cooperative Study.

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7 January 2021

beta-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity

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7 January 2021

Neurodegeneration induced by beta-amyloid peptides in vitro: the role of peptide assembly state

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7 January 2021

Beta-amyloid neurotoxicity requires fibril formation and is inhibited by congo red.

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7 January 2021

Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein

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7 January 2021

Correlative Memory Deficits, Abeta Elevation, and Amyloid Plaques in Transgenic Mice

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7 January 2021

Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology

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7 January 2021

Observation of metastable Abeta amyloid protofibrils by atomic force microscopy

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7 January 2021

Amyloid beta-protein fibrillogenesis. Detection of a protofibrillar intermediate.

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7 January 2021

Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins

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7 January 2021

Participation of presenilin 2 in apoptosis: enhanced basal activity conferred by an Alzheimer mutation

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7 January 2021

Peptide compositions of the cerebrovascular and senile plaque core amyloid deposits of Alzheimer's disease.

1 reference

7 January 2021

beta-Amyloid-(1-42) is a major component of cerebrovascular amyloid deposits: implications for the pathology of Alzheimer disease

1 reference

7 January 2021

Visualization of A beta 42(43) and A beta 40 in senile plaques with end-specific A beta monoclonals: evidence that an initially deposited species is A beta 42(43).

1 reference

7 January 2021

The carboxy terminus of the beta amyloid protein is critical for the seeding of amyloid formation: implications for the pathogenesis of Alzheimer's disease

1 reference

7 January 2021

Trafficking of cell surface beta-amyloid precursor protein: retrograde and transcytotic transport in cultured neurons

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7 January 2021

Intracellular generation and accumulation of amyloid beta-peptide terminating at amino acid 42.

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7 January 2021

Alzheimer's A beta(1-42) is generated in the endoplasmic reticulum/intermediate compartment of NT2N cells

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7 January 2021

Novel beta-secretase cleavage of beta-amyloid precursor protein in the endoplasmic reticulum/intermediate compartment of NT2N cells

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7 January 2021

The Swedish mutation causes early-onset Alzheimer's disease by beta-secretase cleavage within the secretory pathway

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7 January 2021

Distinct sites of intracellular production for Alzheimer's disease A beta40/42 amyloid peptides.

1 reference

7 January 2021

A detergent-insoluble membrane compartment contains A beta in vivo.

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7 January 2021

Identifiers

DOI

10.1038/399A023

1 reference

28 July 2017

1 reference

PubMed ID

10392577