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Gamma -secretase inhibitors repress thymocyte development
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scholarly article
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Europe PubMed Central
PMCID
34695
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11416218%20AND%20SRC:MED&resulttype=core&format=json
retrieved
29 May 2020
title
Gamma -secretase inhibitors repress thymocyte development
(English)
1 reference
stated in
Europe PubMed Central
PMCID
34695
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11416218%20AND%20SRC:MED&resulttype=core&format=json
retrieved
29 May 2020
main subject
thymocyte
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author
Raphael Kopan
series ordinal
8
1 reference
stated in
Europe PubMed Central
PMCID
34695
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11416218%20AND%20SRC:MED&resulttype=core&format=json
retrieved
29 May 2020
author name string
B K Hadland
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1
1 reference
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Europe PubMed Central
PMCID
34695
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11416218%20AND%20SRC:MED&resulttype=core&format=json
retrieved
29 May 2020
N R Manley
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2
1 reference
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Europe PubMed Central
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34695
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11416218%20AND%20SRC:MED&resulttype=core&format=json
retrieved
29 May 2020
D Su
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3
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Europe PubMed Central
PMCID
34695
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11416218%20AND%20SRC:MED&resulttype=core&format=json
retrieved
29 May 2020
G D Longmore
series ordinal
4
1 reference
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Europe PubMed Central
PMCID
34695
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11416218%20AND%20SRC:MED&resulttype=core&format=json
retrieved
29 May 2020
C L Moore
series ordinal
5
1 reference
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Europe PubMed Central
PMCID
34695
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11416218%20AND%20SRC:MED&resulttype=core&format=json
retrieved
29 May 2020
M S Wolfe
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6
1 reference
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Europe PubMed Central
PMCID
34695
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11416218%20AND%20SRC:MED&resulttype=core&format=json
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29 May 2020
E H Schroeter
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7
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29 May 2020
publication date
1 June 2001
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11416218%20AND%20SRC:MED&resulttype=core&format=json
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29 May 2020
published in
Proceedings of the National Academy of Sciences of the United States of America
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Europe PubMed Central
PMCID
34695
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11416218%20AND%20SRC:MED&resulttype=core&format=json
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29 May 2020
volume
98
1 reference
stated in
Europe PubMed Central
PMCID
34695
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11416218%20AND%20SRC:MED&resulttype=core&format=json
retrieved
29 May 2020
page(s)
7487-7491
1 reference
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Europe PubMed Central
PMCID
34695
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11416218%20AND%20SRC:MED&resulttype=core&format=json
retrieved
29 May 2020
issue
13
1 reference
stated in
Europe PubMed Central
PMCID
34695
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11416218%20AND%20SRC:MED&resulttype=core&format=json
retrieved
29 May 2020
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Europe PubMed Central
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11 June 2022
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/PMC34695/fullTextXML
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inferred from PubMed Central ID database lookup
cites work
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Notch1 signaling promotes the maturation of CD4 and CD8 SP thymocytes
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A ligand-induced extracellular cleavage regulates gamma-secretase-like proteolytic activation of Notch1
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Notch signalling via RBP-J promotes myeloid differentiation.
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In search of gamma-secretase: presenilin at the cutting edge
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Suppression of erythroid but not megakaryocytic differentiation of human K562 erythroleukemic cells by notch-1.
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Monocytes express high amounts of Notch and undergo cytokine specific apoptosis following interaction with the Notch ligand, Delta-1.
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The duration of antigen receptor signalling determines CD4+ versus CD8+ T-cell lineage fate.
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10 February 2021
Notch1 deficiency dissociates the intrathymic development of dendritic cells and T cells.
1 reference
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10 February 2021
Notch signaling in T cell development
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10 February 2021
A soluble form of human Delta-like-1 inhibits differentiation of hematopoietic progenitor cells
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Serrate1-induced notch signalling regulates the decision between immunity and tolerance made by peripheral CD4(+) T cells
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Notch1 expression in early lymphopoiesis influences B versus T lineage determination.
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Translating cell biology into therapeutic advances in Alzheimer's disease
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10 February 2021
Expression pattern of notch1, 2 and 3 and Jagged1 and 2 in lymphoid and stromal thymus components: distinct ligand-receptor interactions in intrathymic T cell development
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Deficient T cell fate specification in mice with an induced inactivation of Notch1.
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10 February 2021
Proteolytic release and nuclear translocation of Notch-1 are induced by presenilin-1 and impaired by pathogenic presenilin-1 mutations
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The bHLH gene Hes1 is essential for expansion of early T cell precursors
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Notch signaling: cell fate control and signal integration in development
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Neurogenic phenotypes and altered Notch processing in Drosophila Presenilin mutants.
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10 February 2021
Presenilin is required for activity and nuclear access of Notch in Drosophila
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PubMed Central
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10 February 2021
A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain
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Peptidomimetic probes and molecular modeling suggest that Alzheimer's gamma-secretase is an intramembrane-cleaving aspartyl protease
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10 February 2021
Notch as a mediator of cell fate determination in hematopoiesis: evidence and speculation
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10 February 2021
Notch1-induced delay of human hematopoietic progenitor cell differentiation is associated with altered cell cycle kinetics
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=34695
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10 February 2021
Correlating notch signaling with thymocyte maturation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=34695
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10 February 2021
The cell biology of beta-amyloid precursor protein and presenilin in Alzheimer's disease
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=34695
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10 February 2021
Identity of the beta-globin locus control region binding protein HS2NF5 as the mammalian homolog of the notch-regulated transcription factor suppressor of hairless.
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=34695
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10 February 2021
Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=34695
retrieved
10 February 2021
Notch1 and Notch2 inhibit myeloid differentiation in response to different cytokines
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=34695
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10 February 2021
Notch activity influences the alphabeta versus gammadelta T cell lineage decision
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=34695
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10 February 2021
Inhibition of granulocytic differentiation by mNotch1.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=34695
retrieved
10 February 2021
An activated form of Notch influences the choice between CD4 and CD8 T cell lineages
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=34695
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10 February 2021
The intracellular domain of mouse Notch: a constitutively activated repressor of myogenesis directed at the basic helix-loop-helix region of MyoD.
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=34695
retrieved
10 February 2021
Limited development capacity of the earliest embryonic murine thymus
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=34695
retrieved
10 February 2021
A novel cell surface antigen, immature thymocyte antigen-1, is involved in the differentiation of murine thymocytes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=34695
retrieved
10 February 2021
A human homologue of the Drosophila developmental gene, Notch, is expressed in CD34+ hematopoietic precursors.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=34695
retrieved
10 February 2021
The acquisition of CD4 and CD8 during the differentiation of early thymocytes in short-term culture
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=34695
retrieved
10 February 2021
Identifiers
DOI
10.1073/PNAS.131202798
1 reference
stated in
Europe PubMed Central
PMCID
34695
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11416218%20AND%20SRC:MED&resulttype=core&format=json
retrieved
29 May 2020
ADS bibcode
2001PNAS...98.7487H
0 references
PMCID
34695
1 reference
stated in
Europe PubMed Central
PMCID
34695
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11416218%20AND%20SRC:MED&resulttype=core&format=json
retrieved
29 May 2020
PubMed ID
11416218
1 reference
stated in
Europe PubMed Central
PMCID
34695
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11416218%20AND%20SRC:MED&resulttype=core&format=json
retrieved
29 May 2020
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