(Q34185772)

31 July 2017

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title

Intramembrane proteolysis by presenilins (English)

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31 July 2017

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Steiner H

1

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31 July 2017

Haass C

series ordinal

2

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31 July 2017

publication date

1 December 2000

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Nature Reviews Molecular Cell Biology

31 July 2017

published in

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31 July 2017

volume

1

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31 July 2017

issue

3

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31 July 2017

page(s)

217-224

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https://scigraph.springernature.com/pub.10.1038/35043065

31 July 2017

exact match

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cites work

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Enhanced release of amyloid beta-protein from codon 670/671 "Swedish" mutant beta-amyloid precursor protein occurs in both secretory and endocytic pathways

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7 January 2021

Peptidomimetic probes and molecular modeling suggest that Alzheimer's gamma-secretase is an intramembrane-cleaving aspartyl protease

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7 January 2021

Mechanism of the cleavage specificity of Alzheimer's disease gamma-secretase identified by phenylalanine-scanning mutagenesis of the transmembrane domain of the amyloid precursor protein

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Amyloid beta-peptide is produced by cultured cells during normal metabolism

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7 January 2021

Generation of beta-amyloid in the secretory pathway in neuronal and nonneuronal cells

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7 January 2021

Production of the Alzheimer amyloid beta protein by normal proteolytic processing

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7 January 2021

Isolation and quantification of soluble Alzheimer's beta-peptide from biological fluids

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7 January 2021

Cleavage of amyloid beta peptide during constitutive processing of its precursor

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7 January 2021

Constitutive and regulated alpha-secretase cleavage of Alzheimer's amyloid precursor protein by a disintegrin metalloprotease

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7 January 2021

Evidence that tumor necrosis factor alpha converting enzyme is involved in regulated alpha-secretase cleavage of the Alzheimer amyloid protein precursor

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The ADAM gene family: surface proteins with adhesion and protease activity

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Beta-amyloid precursor protein cleavage by a membrane-bound protease

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7 January 2021

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

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7 January 2021

Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene

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Candidate gene for the chromosome 1 familial Alzheimer's disease locus

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A novel Polish presenilin-1 mutation (P117L) is associated with familial Alzheimer's disease and leads to death as early as the age of 28 years.

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7 January 2021

Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo

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7 January 2021

Evidence for phosphorylation and oligomeric assembly of presenilin 1.

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7 January 2021

The proteolytic fragments of the Alzheimer's disease-associated presenilin-1 form heterodimers and occur as a 100-150-kDa molecular mass complex

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7 January 2021

The presenilin 1 protein is a component of a high molecular weight intracellular complex that contains beta-catenin

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7 January 2021

Stable association of presenilin derivatives and absence of presenilin interactions with APP.

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7 January 2021

Evidence That Intramolecular Associations between Presenilin Domains Are Obligatory for Endoproteolytic Processing

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7 January 2021

Protein topology of presenilin 1

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7 January 2021

Membrane topology of the C. elegans SEL-12 presenilin

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7 January 2021

Additional evidence for an eight-transmembrane-domain topology for Caenorhabditis elegans and human presenilins

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7 January 2021

Evidence for a six-transmembrane domain structure of presenilin 1.

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7 January 2021

Membrane topology of Alzheimer's disease-related presenilin 1. Evidence for the existence of a molecular species with a seven membrane-spanning and one membrane-embedded structure

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7 January 2021

Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

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7 January 2021

Translating cell biology into therapeutic advances in Alzheimer's disease

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Alzheimer's disease: genetic studies and transgenic models

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7 January 2021

Notch signaling: from the outside in

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7 January 2021

Presenilin 1 is required for Notch1 and DII1 expression in the paraxial mesoderm

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7 January 2021

Skeletal and CNS defects in Presenilin-1-deficient mice

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7 January 2021

Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency

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7 January 2021

Mice lacking both presenilin genes exhibit early embryonic patterning defects

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7 January 2021

Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene

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7 January 2021

Assessment of normal and mutant human presenilin function in Caenorhabditis elegans

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7 January 2021

Human presenilin-1, but not familial Alzheimer's disease (FAD) mutants, facilitate Caenorhabditis elegans Notch signalling independently of proteolytic processing

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7 January 2021

A loss of function mutation of presenilin-2 interferes with amyloid beta-peptide production and notch signaling

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7 January 2021

Presenilin-1 differentially facilitates endoproteolysis of the beta-amyloid precursor protein and Notch

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7 January 2021

Presenilin is required for proper morphology and function of neurons in C. elegans

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7 January 2021

Neurogenic phenotypes and altered Notch processing in Drosophila Presenilin mutants.

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7 January 2021

Presenilin is required for activity and nuclear access of Notch in Drosophila

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7 January 2021

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

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7 January 2021

Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain

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7 January 2021

Nuclear access and action of notch in vivo

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7 January 2021

Embryonic lethality in mice homozygous for a processing-deficient allele of Notch1.

1 reference

7 January 2021

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

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7 January 2021

Proteolytic release and nuclear translocation of Notch-1 are induced by presenilin-1 and impaired by pathogenic presenilin-1 mutations

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7 January 2021

Presenilins are required for gamma-secretase cleavage of beta-APP and transmembrane cleavage of Notch-1

1 reference

7 January 2021

Total inactivation of gamma-secretase activity in presenilin-deficient embryonic stem cells.

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7 January 2021

The Notch1 receptor is cleaved constitutively by a furin-like convertase

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7 January 2021

A ligand-induced extracellular cleavage regulates gamma-secretase-like proteolytic activation of Notch1

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7 January 2021

A novel proteolytic cleavage involved in Notch signaling: the role of the disintegrin-metalloprotease TACE

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7 January 2021

Effects of PS1 deficiency on membrane protein trafficking in neurons.

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7 January 2021

L-685,458, an aspartyl protease transition state mimic, is a potent inhibitor of amyloid beta-protein precursor gamma-secretase activity

1 reference

7 January 2021

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

1 reference

7 January 2021

Presenilin complexes with the C-terminal fragments of amyloid precursor protein at the sites of amyloid beta-protein generation

1 reference

7 January 2021

The transmembrane aspartates in presenilin 1 and 2 are obligatory for gamma-secretase activity and amyloid beta-protein generation

1 reference

7 January 2021

Zebrafish (Danio rerio) presenilin promotes aberrant amyloid beta-peptide production and requires a critical aspartate residue for its function in amyloidogenesis

1 reference

7 January 2021

Cell surface presenilin-1 participates in the gamma-secretase-like proteolysis of Notch

1 reference

7 January 2021

Caspase-mediated cleavage is not required for the activity of presenilins in amyloidogenesis and NOTCH signaling

1 reference

7 January 2021

Expression of Alzheimer's disease-associated presenilin-1 is controlled by proteolytic degradation and complex formation

1 reference

7 January 2021

Molecular dissection of domains in mutant presenilin 2 that mediate overproduction of amyloidogenic forms of amyloid beta peptides. Inability of truncated forms of PS2 with familial Alzheimer's disease mutation to increase secretion of Abeta42.

1 reference

7 January 2021

Additive effects of PS1 and APP mutations on secretion of the 42-residue amyloid beta-protein.

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7 January 2021

Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1

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7 January 2021

Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1.

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7 January 2021

Amyloidogenic function of the Alzheimer's disease-associated presenilin 1 in the absence of endoproteolysis

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7 January 2021

The influence of endoproteolytic processing of familial Alzheimer's disease presenilin 2 on abeta42 amyloid peptide formation.

1 reference

7 January 2021

Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state

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7 January 2021

Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing

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7 January 2021

Molecular genetic analysis of familial early-onset Alzheimer's disease linked to chromosome 14q24.3.

1 reference

7 January 2021

Sequence analysis of presenilin-1 gene mutation in Japanese Alzheimer's disease patients.

1 reference

7 January 2021

Evidence that Abeta42 plasma levels in presenilin-1 mutation carriers do not allow for prediction of their clinical phenotype

1 reference

7 January 2021

Glycine 384 is required for presenilin-1 function and is conserved in bacterial polytopic aspartyl proteases

1 reference

7 January 2021

The biological and pathological function of the presenilin-1 Deltaexon 9 mutation is independent of its defect to undergo proteolytic processing

1 reference

7 January 2021

The type 4 prepilin peptidases comprise a novel family of aspartic acid proteases

1 reference

7 January 2021

Regulated intramembrane proteolysis: a control mechanism conserved from bacteria to humans

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7 January 2021

Purification and cloning of amyloid precursor protein beta-secretase from human brain

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7 January 2021

A substrate-based difluoro ketone selectively inhibits Alzheimer's gamma-secretase activity.

1 reference

7 January 2021

Insulin-degrading enzyme regulates extracellular levels of amyloid beta-protein by degradation

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7 January 2021

Identification of the major Abeta1-42-degrading catabolic pathway in brain parenchyma: suppression leads to biochemical and pathological deposition

1 reference

7 January 2021

Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse

1 reference

7 January 2021

Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease

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7 January 2021

Requirements for presenilin-dependent cleavage of notch and other transmembrane proteins.

1 reference

7 January 2021

An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants.

1 reference

7 January 2021

Visualization of A beta 42(43) and A beta 40 in senile plaques with end-specific A beta monoclonals: evidence that an initially deposited species is A beta 42(43).

1 reference

7 January 2021

Presenilin 1 controls gamma-secretase processing of amyloid precursor protein in pre-golgi compartments of hippocampal neurons

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7 January 2021

Endogenous presenilin-1 targets to endocytic rather than biosynthetic compartments

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7 January 2021

Separation of presenilin function in amyloid beta-peptide generation and endoproteolysis of Notch

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7 January 2021

Tripartite management of unfolded proteins in the endoplasmic reticulum

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7 January 2021

Upregulation of BiP and CHOP by the unfolded-protein response is independent of presenilin expression.

1 reference

7 January 2021

A role for presenilin-1 in nuclear accumulation of Ire1 fragments and induction of the mammalian unfolded protein response

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7 January 2021

Presenilin-1 mutations downregulate the signalling pathway of the unfolded-protein response

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7 January 2021

Participation of presenilin 2 in apoptosis: enhanced basal activity conferred by an Alzheimer mutation

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7 January 2021

Alternative cleavage of Alzheimer-associated presenilins during apoptosis by a caspase-3 family protease

1 reference

7 January 2021

Presenilin-mediated modulation of capacitative calcium entry

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7 January 2021

Identifiers

DOI

10.1038/35043065

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Dimensions Publication ID

31 July 2017

1001558323

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