(Q53216983)

12 May 2018

title

Evidence for a six-transmembrane domain structure of presenilin 1. (English)

1 reference

12 May 2018

main subject

transmembrane protein

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author

Sylvain Lehmann

series ordinal

1

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12 May 2018

author name string

R Chiesa

series ordinal

2

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12 May 2018

D A Harris

series ordinal

3

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12 May 2018

language of work or name

English

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publication date

1 May 1997

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12 May 2018

Journal of Biological Chemistry

published in

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12 May 2018

volume

272

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12 May 2018

page(s)

12047-12051

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12 May 2018

issue

18

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12 May 2018

Candidate gene for the chromosome 1 familial Alzheimer's disease locus

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1 reference

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Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene

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Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

21 January 2018

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Molecular genetic analysis of familial early-onset Alzheimer's disease linked to chromosome 14q24.3.

21 January 2018

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The structure of the presenilin 1 (S182) gene and identification of six novel mutations in early onset AD families

21 January 2018

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Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene

21 January 2018

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Mutation of a putative sperm membrane protein in Caenorhabditis elegans prevents sperm differentiation but not its associated meiotic divisions

21 January 2018

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Alzheimer-associated presenilins 1 and 2: neuronal expression in brain and localization to intracellular membranes in mammalian cells.

21 January 2018

1 reference

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Expression and analysis of presenilin 1 in a human neuronal system: localization in cell bodies and dendrites

21 January 2018

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Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo

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Participation of presenilin 2 in apoptosis: enhanced basal activity conferred by an Alzheimer mutation

21 January 2018

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Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice

21 January 2018

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Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo

21 January 2018

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Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

21 January 2018

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Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1

21 January 2018

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Abnormal gel-electrophoretic behavior of presenilin 1 and it's fragment

21 January 2018

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Topology profile for a glutamate receptor: three transmembrane domains and a channel-lining reentrant membrane loop.

21 January 2018

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Expression of fusion proteins of the nicotinic acetylcholine receptor from mammalian muscle identifies the membrane-spanning regions in the alpha and delta subunits

21 January 2018

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N-glycosylation site tagging suggests a three transmembrane domain topology for the glutamate receptor GluR1.

21 January 2018

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Pore loops: an emerging theme in ion channel structure

21 January 2018

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A simple method for displaying the hydropathic character of a protein

21 January 2018

1 reference

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21 January 2018

Identifiers

DOI

10.1074/JBC.272.18.12047

1 reference

12 May 2018

PubMed ID

9115271

1 reference

12 May 2018