(Q24307727)

English

Mammalian APH-1 interacts with presenilin and nicastrin and is required for intramembrane proteolysis of amyloid-beta precursor protein and Notch

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scholarly article

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Mammalian APH-1 interacts with presenilin and nicastrin and is required for intramembrane proteolysis of amyloid-beta precursor protein and Notch (English)

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1 reference

based on heuristic

inferred from title

Aph-1 homolog A, gamma-secretase subunit

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GOA release 2020-03-11

Aph-1 homolog B, gamma-secretase subunit

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GOA release 2020-03-11

amyloid precursor protein catabolic process

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GOA release 2020-03-11

Aph1 homolog C, gamma secretase subunit

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GOA release 2020-03-11

Aph1 homolog A, gamma secretase subunit

1 reference

GOA release 2020-03-11

author name string

Sheu-Fen Lee

1

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Sanjiv Shah

2

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Hongqiao Li

3

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Cong Yu

4

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Weiping Han

5

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Gang Yu

6

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language of work or name

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publication date

22 November 2002

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Journal of Biological Chemistry

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277

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47

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45013-9

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Regulated intramembrane proteolysis: a control mechanism conserved from bacteria to humans

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208164200

21 January 2018

A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208164200

21 January 2018

The presenilin 1 protein is a component of a high molecular weight intracellular complex that contains beta-catenin

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208164200

21 January 2018

Mutation of conserved aspartates affects maturation of both aspartate mutant and endogenous presenilin 1 and presenilin 2 complexes

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208164200

21 January 2018

Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208164200

21 January 2018

Aph-2/Nicastrin: an essential component of gamma-secretase and regulator of Notch signaling and Presenilin localization

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208164200

21 January 2018

Presenilin 1 is required for maturation and cell surface accumulation of nicastrin

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208164200

21 January 2018

Presenilin and nicastrin regulate each other and determine amyloid beta-peptide production via complex formation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208164200

21 January 2018

Mature glycosylation and trafficking of nicastrin modulate its binding to presenilins

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208164200

21 January 2018

Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208164200

21 January 2018

Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208164200

21 January 2018

Activity-dependent isolation of the presenilin- gamma -secretase complex reveals nicastrin and a gamma substrate

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208164200

21 January 2018

Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208164200

21 January 2018

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208164200

21 January 2018

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208164200

21 January 2018

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208164200

21 January 2018

Nicastrin binds to membrane-tethered Notch

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208164200

21 January 2018

Nicastrin is required for Presenilin-mediated transmembrane cleavage in Drosophila

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208164200

21 January 2018

Nicastrin is required for gamma-secretase cleavage of the Drosophila Notch receptor

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208164200

21 January 2018

Drosophila nicastrin is essential for the intramembranous cleavage of notch

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208164200

21 January 2018

Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208164200

21 January 2018

APH-2/nicastrin functions in LIN-12/Notch signaling in the Caenorhabditis elegans somatic gonad.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208164200

21 January 2018

APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryos

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208164200

21 January 2018

aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208164200

21 January 2018

Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208164200

21 January 2018

A sensitive and quantitative assay for measuring cleavage of presenilin substrates

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208164200

21 January 2018

Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208164200

21 January 2018

Improved electrophoretic separation and immunoblotting of beta-amyloid (A beta) peptides 1-40, 1-42, and 1-43.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208164200

21 January 2018

Evidence that levels of presenilins (PS1 and PS2) are coordinately regulated by competition for limiting cellular factors.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208164200

21 January 2018

A full genome scan for late onset Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208164200

21 January 2018

Identifiers

10.1074/JBC.M208164200

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

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