(Q21432647)

http://www.ebi.ac.uk/interpro/protein/Q9DCZ9

group translocator

1 reference

Transporter Classification Database ID

4.G.1.1.1

retrieved

2 October 2019

based on heuristic

hierarchical database ID heuristic

membrane protein

1 reference

based on heuristic

inferred from GOA cell component → membrane

1 reference

25 May 2022

1 reference

25 May 2022

1 reference

14 February 2019

Mammalian APH-1 interacts with presenilin and nicastrin and is required for intramembrane proteolysis of amyloid-beta precursor protein and Notch

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9DCZ9

APH-1a is the principal mammalian APH-1 isoform present in gamma-secretase complexes during embryonic development

ISA

endopeptidase activity

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9DCZ9&geneProductId=UniProtKB:Q9DCZ9

integral component of membrane

IGI

cell component

3 references

14 February 2019

Mammalian APH-1 interacts with presenilin and nicastrin and is required for intramembrane proteolysis of amyloid-beta precursor protein and Notch

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9DCZ9

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9DCZ9

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9DCZ9

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9DCZ9

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9DCZ9

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

IEA

endoplasmic reticulum

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9DCZ9

integral component of plasma membrane

IBA

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9DCZ9

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

IBA

gamma-secretase complex

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9DCZ9

3 references

27 March 2018

Mammalian APH-1 interacts with presenilin and nicastrin and is required for intramembrane proteolysis of amyloid-beta precursor protein and Notch

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9DCZ9&geneProductId=UniProtKB:Q9DCZ9

27 March 2018

APH-1a is the principal mammalian APH-1 isoform present in gamma-secretase complexes during embryonic development

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9DCZ9&geneProductId=UniProtKB:Q9DCZ9

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9DCZ9&geneProductId=UniProtKB:Q9DCZ9

positive regulation of catalytic activity

IEA

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9DCZ9

Gamma-secretase activity is dispensable for mesenchyme-to-epithelium transition but required for podocyte and proximal tubule formation in developing mouse kidney

IEA

metanephros development

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9DCZ9

Notch receptor processing

IMP

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9DCZ9

4 references

14 February 2019

Mammalian APH-1 interacts with presenilin and nicastrin and is required for intramembrane proteolysis of amyloid-beta precursor protein and Notch

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9DCZ9

14 February 2019

APH-1a is the principal mammalian APH-1 isoform present in gamma-secretase complexes during embryonic development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9DCZ9

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9DCZ9

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9DCZ9