(Q41748279)

English

Aspartate mutations in presenilin and gamma-secretase inhibitors both impair notch1 proteolysis and nuclear translocation with relative preservation of notch1 signaling

scientific article published on August 2000

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scholarly article

1 reference

Europe PubMed Central

8 October 2017

Aspartate mutations in presenilin and gamma-secretase inhibitors both impair notch1 proteolysis and nuclear translocation with relative preservation of notch1 signaling (English)

1 reference

Europe PubMed Central

8 October 2017

1 reference

based on heuristic

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author name string

Berezovska O

1

1 reference

Europe PubMed Central

8 October 2017

Jack C

2

1 reference

Europe PubMed Central

8 October 2017

McLean P

3

1 reference

Europe PubMed Central

8 October 2017

Aster JC

4

1 reference

Europe PubMed Central

8 October 2017

Hicks C

5

1 reference

Europe PubMed Central

8 October 2017

Xia W

6

1 reference

Europe PubMed Central

8 October 2017

Wolfe MS

7

1 reference

Europe PubMed Central

8 October 2017

Kimberly WT

8

1 reference

Europe PubMed Central

8 October 2017

Weinmaster G

9

1 reference

Europe PubMed Central

8 October 2017

Selkoe DJ

10

1 reference

Europe PubMed Central

8 October 2017

Hyman BT

11

1 reference

Europe PubMed Central

8 October 2017

language of work or name

0 references

publication date

1 August 2000

1 reference

Europe PubMed Central

8 October 2017

Journal of Neurochemistry

1 reference

Europe PubMed Central

8 October 2017

75

1 reference

Europe PubMed Central

8 October 2017

2

1 reference

Europe PubMed Central

8 October 2017

583-593

1 reference

Europe PubMed Central

8 October 2017

Presenilin 1 controls gamma-secretase processing of amyloid precursor protein in pre-golgi compartments of hippocampal neurons

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2000.0750583.X

21 January 2018

Notch signaling

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2000.0750583.X

21 January 2018

Notch signaling: cell fate control and signal integration in development

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2000.0750583.X

21 January 2018

Oncogenic forms of NOTCH1 lacking either the primary binding site for RBP-Jkappa or nuclear localization sequences retain the ability to associate with RBP-Jkappa and activate transcription

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2000.0750583.X

21 January 2018

Lack of requirement for presenilin1 in Notch1 signaling.

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2000.0750583.X

21 January 2018

Notch is expressed in adult brain, is coexpressed with presenilin-1, and is altered in Alzheimer disease.

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2000.0750583.X

21 January 2018

The Alzheimer-related gene presenilin 1 facilitates notch 1 in primary mammalian neurons.

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2000.0750583.X

21 January 2018

Notch1 inhibits neurite outgrowth in postmitotic primary neurons.

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2000.0750583.X

21 January 2018

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2000.0750583.X

21 January 2018

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2000.0750583.X

21 January 2018

The Drosophila Numb protein inhibits signaling of the Notch receptor during cell-cell interaction in sensory organ lineage

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2000.0750583.X

21 January 2018

The impact of different presenilin 1 andpresenilin 2 mutations on amyloid deposition, neurofibrillary changes and neuronal loss in the familial Alzheimer's disease brain: evidence for other phenotype-modifying factors.

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2000.0750583.X

21 January 2018

Signal transduction. Notch takes a short cut.

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2000.0750583.X

21 January 2018

Control of daughter cell fates during asymmetric division: interaction of Numb and Notch

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2000.0750583.X

21 January 2018

Truncated mammalian Notch1 activates CBF1/RBPJk-repressed genes by a mechanism resembling that of Epstein-Barr virus EBNA2

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2000.0750583.X

21 January 2018

Presenilin-1 mutations downregulate the signalling pathway of the unfolded-protein response

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2000.0750583.X

21 January 2018

Signal transduction by activated mNotch: importance of proteolytic processing and its regulation by the extracellular domain.

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2000.0750583.X

21 January 2018

The E280A presenilin 1 Alzheimer mutation produces increased A beta 42 deposition and severe cerebellar pathology.

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2000.0750583.X

21 January 2018

Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2000.0750583.X

21 January 2018

Constitutively active human Notch1 binds to the transcription factor CBF1 and stimulates transcription through a promoter containing a CBF1-responsive element

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2000.0750583.X

21 January 2018

Advanced mammalian gene transfer: high titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2000.0750583.X

21 January 2018

Effects of PS1 deficiency on membrane protein trafficking in neurons.

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2000.0750583.X

21 January 2018

Calcium depletion dissociates and activates heterodimeric notch receptors

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2000.0750583.X

21 January 2018

Cell surface presenilin-1 participates in the gamma-secretase-like proteolysis of Notch

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2000.0750583.X

21 January 2018

Evidence for a physical interaction between presenilin and Notch

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2000.0750583.X

21 January 2018

Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2000.0750583.X

21 January 2018

Suppressor of Hairless, the Drosophila homolog of the mouse recombination signal-binding protein gene, controls sensory organ cell fates

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2000.0750583.X

21 January 2018

Skeletal and CNS defects in Presenilin-1-deficient mice

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2000.0750583.X

21 January 2018

Proteolytic release and nuclear translocation of Notch-1 are induced by presenilin-1 and impaired by pathogenic presenilin-1 mutations

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2000.0750583.X

21 January 2018

Numb antagonizes Notch signaling to specify sibling neuron cell fates

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2000.0750583.X

21 January 2018

NUMB localizes in the basal cortex of mitotic avian neuroepithelial cells and modulates neuronal differentiation by binding to NOTCH-1.

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2000.0750583.X

21 January 2018

Notch receptor activation inhibits oligodendrocyte differentiation.

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2000.0750583.X

21 January 2018

The ins and outs of notch signaling

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2000.0750583.X

21 January 2018

A substrate-based difluoro ketone selectively inhibits Alzheimer's gamma-secretase activity.

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2000.0750583.X

21 January 2018

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2000.0750583.X

21 January 2018

Presenilin 1 is required for Notch1 and DII1 expression in the paraxial mesoderm

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2000.0750583.X

21 January 2018

Characterization of Drosophila Presenilin and its colocalization with Notch during development.

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2000.0750583.X

21 January 2018

Neurogenic phenotypes and altered Notch processing in Drosophila Presenilin mutants.

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2000.0750583.X

21 January 2018

Asymmetric localization of a mammalian numb homolog during mouse cortical neurogenesis

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2000.0750583.X

21 January 2018

Identifiers

10.1046/J.1471-4159.2000.0750583.X

1 reference

Europe PubMed Central

8 October 2017

1 reference

Europe PubMed Central

8 October 2017

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