(Q44420427)

2 December 2017

title

The mechanism of gamma-secretase: multiple inhibitor binding sites for transition state analogs and small molecule inhibitors (English)

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2 December 2017

Gaochao Tian

1

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2 December 2017

Smita V Ghanekar

2

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2 December 2017

David Aharony

3

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2 December 2017

Ashok B Shenvi

4

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2 December 2017

Robert T Jacobs

5

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2 December 2017

Xiaodong Liu

6

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2 December 2017

Barry D Greenberg

7

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2 December 2017

language of work or name

English

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publication date

28 April 2003

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Journal of Biological Chemistry

2 December 2017

published in

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2 December 2017

volume

278

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2 December 2017

issue

31

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2 December 2017

page(s)

28968-28975

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Gamma-secretase: never more enigmatic

2 December 2017

cites work

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Abeta toxicity in Alzheimer's disease: globular oligomers (ADDLs) as new vaccine and drug targets

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Human aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor protein

21 January 2018

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Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity

21 January 2018

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Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

21 January 2018

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Structure of the protease domain of memapsin 2 (beta-secretase) complexed with inhibitor

21 January 2018

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Biochemical characterization of the gamma-secretase activity that produces beta-amyloid peptides

21 January 2018

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The Role of presenilins in gamma-secretase activity

21 January 2018

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Aspartyl protease inhibitor pepstatin binds to the presenilins of Alzheimer's disease.

21 January 2018

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The presenilin 1 protein is a component of a high molecular weight intracellular complex that contains beta-catenin

21 January 2018

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Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state

21 January 2018

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Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

21 January 2018

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Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1

21 January 2018

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Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing

21 January 2018

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aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation

21 January 2018

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Mammalian APH-1 interacts with presenilin and nicastrin and is required for intramembrane proteolysis of amyloid-beta precursor protein and Notch

21 January 2018

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PEN-2 is an integral component of the gamma-secretase complex required for coordinated expression of presenilin and nicastrin

21 January 2018

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Proteolytic release and nuclear translocation of Notch-1 are induced by presenilin-1 and impaired by pathogenic presenilin-1 mutations

21 January 2018

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Notch signaling: cell fate control and signal integration in development

21 January 2018

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Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain

21 January 2018

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gamma -Secretase cleavage and nuclear localization of ErbB-4 receptor tyrosine kinase

21 January 2018

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Presenilin-dependent gamma-secretase-like intramembrane cleavage of ErbB4.

21 January 2018

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A presenilin-1/gamma-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions

21 January 2018

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Presenilin-dependent intramembrane proteolysis of CD44 leads to the liberation of its intracellular domain and the secretion of an Abeta-like peptide

21 January 2018

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Linear non-competitive inhibition of solubilized human gamma-secretase by pepstatin A methylester, L685458, sulfonamides, and benzodiazepines

21 January 2018

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L-685,458, an aspartyl protease transition state mimic, is a potent inhibitor of amyloid beta-protein precursor gamma-secretase activity

21 January 2018

1 reference

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Activity-dependent isolation of the presenilin- gamma -secretase complex reveals nicastrin and a gamma substrate

21 January 2018

1 reference

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Interaction with telencephalin and the amyloid precursor protein predicts a ring structure for presenilins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300905200

A Novel γ-Secretase Assay Based on Detection of the Putative C-terminal Fragment-γ of Amyloid β Protein Precursor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300905200

gamma-Secretase, evidence for multiple proteolytic activities and influence of membrane positioning of substrate on generation of amyloid beta peptides of varying length

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300905200

Peptidomimetic probes and molecular modeling suggest that Alzheimer's gamma-secretase is an intramembrane-cleaving aspartyl protease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300905200

21 January 2018

Identifiers

DOI

10.1074/JBC.M300905200

1 reference

2 December 2017

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