(Q57371926)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11035007%20AND%20SRC:MED&resulttype=core&format=json

1 November 2019

title

A novel gamma -secretase assay based on detection of the putative C-terminal fragment-gamma of amyloid beta protein precursor (English)

1 reference

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1 November 2019

7

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1 November 2019

Kumar Sambamurti

9

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1 November 2019

author name string

Pinnix I

1

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1 November 2019

Musunuru U

2

1 reference

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1 November 2019

Tun H

3

1 reference

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1 November 2019

Sridharan A

4

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1 November 2019

Golde T

5

1 reference

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1 November 2019

Eckman C

6

1 reference

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1 November 2019

Onstead L

8

1 reference

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1 November 2019

language of work or name

English

0 references

publication date

1 January 2001

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11035007%20AND%20SRC:MED&resulttype=core&format=json

Journal of Biological Chemistry

1 November 2019

published in

1 reference

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1 November 2019

volume

276

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1 November 2019

issue

1

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1 November 2019

page(s)

481-487

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Cellular mechanisms of beta-amyloid production and secretion

1 November 2019

cites work

1 reference

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Cellular processing of beta-amyloid precursor protein and the genesis of amyloid beta-peptide

21 January 2018

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The molecular pathology of Alzheimer's disease

21 January 2018

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APP processing, A beta-amyloidogenesis, and the pathogenesis of Alzheimer's disease

21 January 2018

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Generation of beta-amyloid in the secretory pathway in neuronal and nonneuronal cells

21 January 2018

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Physiological production of the beta-amyloid protein and the mechanism of Alzheimer's disease

21 January 2018

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Production of the Alzheimer amyloid beta protein by normal proteolytic processing

21 January 2018

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Isolation and quantification of soluble Alzheimer's beta-peptide from biological fluids

21 January 2018

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Amyloid beta-peptide is produced by cultured cells during normal metabolism

21 January 2018

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An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants.

21 January 2018

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The E280A presenilin 1 Alzheimer mutation produces increased A beta 42 deposition and severe cerebellar pathology.

21 January 2018

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Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo

21 January 2018

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Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

21 January 2018

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The Alzheimer family of diseases: many etiologies, one pathogenesis?

21 January 2018

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Changes of the trans-activating potential of AP-1 transcription factor during cyclosporin A-induced apoptosis of glioma cells are mediated by phosphorylation and alterations of AP-1 composition

21 January 2018

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Secretion of beta-amyloid precursor protein cleaved at the amino terminus of the beta-amyloid peptide

21 January 2018

1 reference

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Exact cleavage site of Alzheimer amyloid precursor in neuronal PC-12 cells

21 January 2018

1 reference

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Cleavage of amyloid beta peptide during constitutive processing of its precursor

21 January 2018

1 reference

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Potentially Amyloidogenic, Carboxyl-Terminal Derivatives of the Amyloid Protein Precursor

21 January 2018

1 reference

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Neurotoxicity of a fragment of the amyloid precursor associated with Alzheimer's disease

21 January 2018

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Impairments in learning and memory accompanied by neurodegeneration in mice transgenic for the carboxyl-terminus of the amyloid precursor protein.

21 January 2018

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A second cytotoxic proteolytic peptide derived from amyloid beta-protein precursor

21 January 2018

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Human aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor protein

21 January 2018

1 reference

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Purification and cloning of amyloid precursor protein beta-secretase from human brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M005968200

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M005968200

Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M005968200

Thimet oligopeptidase cleaves the full-length Alzheimer amyloid precursor protein at a beta-secretase cleavage site in COS cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M005968200

Glycosylphosphatidylinositol-anchored proteins play an important role in the biogenesis of the Alzheimer's amyloid beta-protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M005968200

Diverse cell surface protein ectodomains are shed by a system sensitive to metalloprotease inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M005968200

Evidence that tumor necrosis factor alpha converting enzyme is involved in regulated alpha-secretase cleavage of the Alzheimer amyloid protein precursor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M005968200

Constitutive and regulated alpha-secretase cleavage of Alzheimer's amyloid precursor protein by a disintegrin metalloprotease

21 January 2018

1 reference

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In search of gamma-secretase: presenilin at the cutting edge

21 January 2018

1 reference

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Candidate .gamma.-Secretases in the Generation of the Carboxyl Terminus of the Alzheimer's Disease .beta.A4 Amyloid: Possible Involvement of Cathepsin D

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M005968200

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M005968200

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M005968200

Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M005968200

Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M005968200

Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M005968200

A substrate-based difluoro ketone selectively inhibits Alzheimer's gamma-secretase activity.

21 January 2018

1 reference

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A new syntaxin family member implicated in targeting of intracellular transport vesicles

21 January 2018

1 reference

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Identification and localization of synaptophysin, an integral membrane glycoprotein of Mr 38,000 characteristic of presynaptic vesicles.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M005968200

Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1

21 January 2018

1 reference

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Proteolytic processing of the Alzheimer's disease amyloid precursor protein within its cytoplasmic domain by caspase-like proteases.

21 January 2018

1 reference

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Benzolactam (BL) enhances sAPP secretion in fibroblasts and in PC12 cells

21 January 2018

1 reference

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Caspase-6 role in apoptosis of human neurons, amyloidogenesis, and Alzheimer's disease.

21 January 2018

1 reference

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Presenilin 1 binds to amyloid precursor protein directly.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M005968200

Inhibiting amyloid precursor protein C-terminal cleavage promotes an interaction with presenilin 1.

21 January 2018

1 reference

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Interaction between amyloid precursor protein and presenilins in mammalian cells: implications for the pathogenesis of Alzheimer disease

21 January 2018

1 reference

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Phosphorylation, subcellular localization, and membrane orientation of the Alzheimer's disease-associated presenilins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M005968200

Presenilin 1 controls gamma-secretase processing of amyloid precursor protein in pre-golgi compartments of hippocampal neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M005968200

A detergent-insoluble membrane compartment contains A beta in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M005968200

Co-purification and direct interaction of Ras with caveolin, an integral membrane protein of caveolae microdomains. Detergent-free purification of caveolae microdomains

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M005968200

Generation of Alzheimer amyloid beta peptide through nonspecific proteolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M005968200

Identification of the major Abeta1-42-degrading catabolic pathway in brain parenchyma: suppression leads to biochemical and pathological deposition

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M005968200

Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M005968200

Second-site cleavage in sterol regulatory element-binding protein occurs at transmembrane junction as determined by cysteine panning

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M005968200

Selective Degradation of Cytosolic Proteins by Lysosomesa

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M005968200

Total inactivation of gamma-secretase activity in presenilin-deficient embryonic stem cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M005968200

21 January 2018

Identifiers

DOI

10.1074/JBC.M005968200

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11035007%20AND%20SRC:MED&resulttype=core&format=json

1 November 2019

1 reference