(Q40696144)

English

The mechanism of gamma-secretase activities through high molecular weight complex formation of presenilins is conserved in Drosophila melanogaster and mammals

scientific article published on 17 October 2002

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

The mechanism of gamma-secretase activities through high molecular weight complex formation of presenilins is conserved in Drosophila melanogaster and mammals (English)

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

Drosophila melanogaster

0 references

4

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

author name string

Nobumasa Takasugi

1

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

Yasuko Takahashi

2

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

Yuichi Morohashi

3

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

Takeshi Iwatsubo

5

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

language of work or name

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publication date

17 October 2002

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

number of pages

8

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based on heuristic

inferred from page(s)

Journal of Biological Chemistry

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

277

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

51

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

50198-50205

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205352200

21 January 2018

Evidence for phosphorylation and oligomeric assembly of presenilin 1.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205352200

21 January 2018

The presenilin 1 protein is a component of a high molecular weight intracellular complex that contains beta-catenin

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205352200

21 January 2018

Endoproteolytic processing and stabilization of wild-type and mutant presenilin

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205352200

21 January 2018

Gamma-secretase-mediated proteolysis in cell-surface-receptor signalling

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205352200

21 January 2018

Total inactivation of gamma-secretase activity in presenilin-deficient embryonic stem cells.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205352200

21 January 2018

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205352200

21 January 2018

Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205352200

21 January 2018

Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205352200

21 January 2018

Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205352200

21 January 2018

Activity-dependent isolation of the presenilin- gamma -secretase complex reveals nicastrin and a gamma substrate

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205352200

21 January 2018

The first proline of PALP motif at the C terminus of presenilins is obligatory for stabilization, complex formation, and gamma-secretase activities of presenilins

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205352200

21 January 2018

The presenilin 2 mutation (N141I) linked to familial Alzheimer disease (Volga German families) increases the secretion of amyloid beta protein ending at the 42nd (or 43rd) residue

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205352200

21 January 2018

Cloning and characterization of the Drosophila presenilin homologue

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205352200

21 January 2018

Molecular cloning and characterization of CALP/KChIP4, a novel EF-hand protein interacting with presenilin 2 and voltage-gated potassium channel subunit Kv4

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205352200

21 January 2018

Subcellular compartment and molecular subdomain of beta-amyloid precursor protein relevant to the Abeta 42-promoting effects of Alzheimer mutant presenilin 2.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205352200

21 January 2018

Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205352200

21 January 2018

Complex N-glycosylated form of nicastrin is stabilized and selectively bound to presenilin fragments.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205352200

21 January 2018

Molecular dissection of domains in mutant presenilin 2 that mediate overproduction of amyloidogenic forms of amyloid beta peptides. Inability of truncated forms of PS2 with familial Alzheimer's disease mutation to increase secretion of Abeta42.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205352200

21 January 2018

Visualization of A beta 42(43) and A beta 40 in senile plaques with end-specific A beta monoclonals: evidence that an initially deposited species is A beta 42(43).

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205352200

21 January 2018

Posttranslational modification and plasma membrane localization of the Drosophila melanogaster presenilin.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205352200

21 January 2018

Evidence that levels of presenilins (PS1 and PS2) are coordinately regulated by competition for limiting cellular factors

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205352200

21 January 2018

A loss of function mutation of presenilin-2 interferes with amyloid beta-peptide production and notch signaling

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205352200

21 January 2018

Presenilin is required for activity and nuclear access of Notch in Drosophila

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205352200

21 January 2018

Neurogenic phenotypes and altered Notch processing in Drosophila Presenilin mutants.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205352200

21 January 2018

Requirements for presenilin-dependent cleavage of notch and other transmembrane proteins.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205352200

21 January 2018

A Drosophila gene encoding a protein resembling the human beta-amyloid protein precursor

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205352200

21 January 2018

Transgenic Drosophila expressing human amyloid precursor protein show gamma-secretase activity and a blistered-wing phenotype

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205352200

21 January 2018

Mechanism of the cleavage specificity of Alzheimer's disease gamma-secretase identified by phenylalanine-scanning mutagenesis of the transmembrane domain of the amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205352200

21 January 2018

Zebrafish (Danio rerio) presenilin promotes aberrant amyloid beta-peptide production and requires a critical aspartate residue for its function in amyloidogenesis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205352200

21 January 2018

A loss of function mutant of the presenilin homologue SEL-12 undergoes aberrant endoproteolysis in Caenorhabditis elegans and increases abeta 42 generation in human cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205352200

21 January 2018

Nicastrin is required for gamma-secretase cleavage of the Drosophila Notch receptor

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205352200

21 January 2018

aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205352200

21 January 2018

Lipid composition of subcellular membranes from larvae and prepupae of Drosophila melanogaster.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205352200

21 January 2018

Presenilins are required for gamma-secretase cleavage of beta-APP and transmembrane cleavage of Notch-1

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205352200

21 January 2018

Presenilin-1 and -2 are molecular targets for gamma-secretase inhibitors

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205352200

21 January 2018

Long Amyloid .beta.-Protein Secreted from Wild-Type Human Neuroblastoma IMR-32 Cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205352200

21 January 2018

Identifiers

10.1074/JBC.M205352200

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

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