(Q35032054)

5 August 2017

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title

Alzheimer disease gamma-secretase: a complex story of GxGD-type presenilin proteases (English)

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5 August 2017

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1

Christian Haass

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author name string

Harald Steiner

series ordinal

2

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5 August 2017

publication date

1 December 2002

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5 August 2017

published in

Trends in Cell Biology

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5 August 2017

volume

12

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5 August 2017

issue

12

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5 August 2017

page(s)

556-562

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Alzheimer's disease: genes, proteins, and therapy

5 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2902394-2

7 January 2021

Intramembrane proteolysis by presenilins

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2902394-2

7 January 2021

Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency

1 reference

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7 January 2021

Total inactivation of gamma-secretase activity in presenilin-deficient embryonic stem cells.

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7 January 2021

Presenilins are required for gamma-secretase cleavage of beta-APP and transmembrane cleavage of Notch-1

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2902394-2

7 January 2021

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2902394-2

7 January 2021

Effects of PS1 deficiency on membrane protein trafficking in neurons

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7 January 2021

Are presenilins intramembrane-cleaving proteases? Implications for the molecular mechanism of Alzheimer's disease

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7 January 2021

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

1 reference

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7 January 2021

A loss of function mutation of presenilin-2 interferes with amyloid beta-peptide production and notch signaling

1 reference

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7 January 2021

Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2902394-2

7 January 2021

Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2902394-2

7 January 2021

Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1.

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2902394-2

7 January 2021

Pharmacological knock-down of the presenilin 1 heterodimer by a novel gamma -secretase inhibitor: implications for presenilin biology

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2902394-2

7 January 2021

Glycine 384 is required for presenilin-1 function and is conserved in bacterial polytopic aspartyl proteases

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2902394-2

7 January 2021

The type 4 prepilin peptidases comprise a novel family of aspartic acid proteases

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2902394-2

7 January 2021

Identification of signal peptide peptidase, a presenilin-type aspartic protease

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2902394-2

7 January 2021

Identification of a novel family of presenilin homologues

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2902394-2

7 January 2021

The proteolytic fragments of the Alzheimer's disease-associated presenilin-1 form heterodimers and occur as a 100-150-kDa molecular mass complex

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2902394-2

7 January 2021

The presenilin 1 protein is a component of a high molecular weight intracellular complex that contains beta-catenin

1 reference

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7 January 2021

Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2902394-2

7 January 2021

Presenilin and nicastrin regulate each other and determine amyloid beta-peptide production via complex formation

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2902394-2

7 January 2021

aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2902394-2

7 January 2021

Nicastrin is required for gamma-secretase cleavage of the Drosophila Notch receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2902394-2

7 January 2021

Presenilin 1 is required for maturation and cell surface accumulation of nicastrin

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2902394-2

7 January 2021

APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryos

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2902394-2

7 January 2021

PEN-2 is an integral component of the gamma-secretase complex required for coordinated expression of presenilin and nicastrin

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2902394-2

7 January 2021

Evidence That Levels of Presenilins (PS1 and PS2) Are Coordinately Regulated by Competition for Limiting Cellular Factors

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2902394-2

7 January 2021

Notch signaling: from the outside in

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2902394-2

7 January 2021

Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2902394-2

7 January 2021

Skeletal and CNS defects in Presenilin-1-deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2902394-2

7 January 2021

Presenilin 1 is required for Notch1 and DII1 expression in the paraxial mesoderm

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2902394-2

7 January 2021

Mice lacking both presenilin genes exhibit early embryonic patterning defects

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2902394-2

7 January 2021

Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2902394-2

7 January 2021

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2902394-2

7 January 2021

Drosophila nicastrin is essential for the intramembranous cleavage of notch

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2902394-2

7 January 2021

Nicastrin is required for Presenilin-mediated transmembrane cleavage in Drosophila

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2902394-2

7 January 2021

Conservation of the biochemical mechanisms of signal transduction among mammalian Notch family members

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2902394-2

7 January 2021

Murine notch homologs (N1-4) undergo presenilin-dependent proteolysis

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2902394-2

7 January 2021

gamma -Secretase cleavage and nuclear localization of ErbB-4 receptor tyrosine kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2902394-2

7 January 2021

Presenilin-dependent gamma-secretase-like intramembrane cleavage of ErbB4.

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2902394-2

7 January 2021

A presenilin-1/gamma-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2902394-2

7 January 2021

Presenilin-dependent intramembrane proteolysis of CD44 leads to the liberation of its intracellular domain and the secretion of an Abeta-like peptide

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2902394-2

7 January 2021

A RIP tide in neuronal signal transduction

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2902394-2

7 January 2021

A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2902394-2

7 January 2021

Exchange of N-CoR corepressor and Tip60 coactivator complexes links gene expression by NF-kappaB and beta-amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2902394-2

7 January 2021

Presenilin-dependent gamma-secretase processing of beta-amyloid precursor protein at a site corresponding to the S3 cleavage of Notch

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2902394-2

7 January 2021

Distinct intramembrane cleavage of the beta-amyloid precursor protein family resembling gamma-secretase-like cleavage of Notch

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2902394-2

7 January 2021

Characterization of a presenilin-mediated amyloid precursor protein carboxyl-terminal fragment gamma. Evidence for distinct mechanisms involved in gamma -secretase processing of the APP and Notch1 transmembrane domains

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2902394-2

7 January 2021

A novel epsilon-cleavage within the transmembrane domain of the Alzheimer amyloid precursor protein demonstrates homology with Notch processing

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2902394-2

7 January 2021

Presenilins mediate a dual intramembranous gamma-secretase cleavage of Notch-1.

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2902394-2

7 January 2021

10.1016/S0962-8924(02)02394-2

Identifiers

DOI

1 reference

5 August 2017

1 reference